A5101519640- Pain Mechanisms and Treatments
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Anesthesia and Pain Management
- Medical Research and Treatments
- Biochemical effects in animals
- Gestational Diabetes Research and Management
- Sleep and Wakefulness Research
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Asthma and respiratory diseases
- Anesthesia and Sedative Agents
- Histiocytic Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pesticide and Herbicide Environmental Studies
- Cancer-related gene regulation
- Advanced Neuroimaging Techniques and Applications
- Pregnancy-related medical research
- Sleep and related disorders
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease and Transplantation
- Pain Management and Placebo Effect
- Ultrasound in Clinical Applications
- Cerebrospinal fluid and hydrocephalus
First Affiliated Hospital of Zhengzhou University
2017-2025
Ningxia Medical University
2022
Second Xiangya Hospital of Central South University
2020
Central South University
2020
Rutgers, The State University of New Jersey
2017-2018
Ningbo No. 2 Hospital
2018
Rutgers New Jersey Medical School
2017
National Clinical Research Center for Digestive Diseases
2017
Second Affiliated Hospital of Zhejiang University
2014-2017
First People's Hospital of Kunshan
2014-2015
MTOR (mechanistic target of rapamycin [serine/threonine kinase]) plays a crucial role in many major cellular processes including metabolism, proliferation and macroautophagy/autophagy induction, is also implicated growing number proliferative metabolic diseases. Both autophagy have been suggested to be involved lung disorders, however, little known about the pulmonary epithelium context acute injury (ALI). In present study, we observed that lipopolysaccharide (LPS) stimulation induced...
Postoperative pain is common in pediatric urological surgery. The study assess the impact of perioperative intravenous infusion low-dose esketamine on postoperative
Changes in gene transcription the dorsal root ganglion (DRG) after nerve trauma contribute to genesis of neuropathic pain. We report that peripheral caused by chronic constriction injury (CCI) increased abundance factor C/EBPβ (CCAAT/enhancer binding protein β) DRG. Blocking this increase mitigated development and maintenance CCI-induced mechanical, thermal, cold pain hypersensitivities without affecting basal responses acute locomotor activity. Conversely, mimicking produced...
N6-methyladenosine (m6A) is the most abundant methylation modification on mRNA in mammals. Fat mass and obesity-related protein (FTO) main RNA m6A demethylase. FTO involved occurrence maintenance of neuropathic pain (NP). NP often induces mental disorders. We found that downregulated expression anterior cingulate cortex (ACC), inhibited matrix metalloproteinase-9 (MMP-9) ACC, maladjusted brain-derived neurotrophic factor precursor (proBDNF) mature (mBDNF) levels induced anxiety-...
Sleep is crucial for sustaining normal physiological functions, and sleep deprivation has been associated with increased pain sensitivity. The histone deacetylases (HDACs) are known to significantly regulate in regulating neuropathic pain, but their involvement nociceptive hypersensitivity during still not fully understood. Utilizing a modified multi-platform water environment technique establish model. We measured the expression levels of HDAC1/2 medial prefrontal cortex (mPFC) through...
Abstract Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) after peripheral nerve injury. Transcription factors control expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a factor, contributed neuropathic caused by chronic constriction injury (CCI) of sciatic nerve. Chronic produced time-dependent increase level OCT1 protein ipsilateral L4/5 DRG, but not spinal cord. Blocking through microinjection siRNA into DRG...
Sleep is essential for the body's repair and recovery, including supplementation with antioxidants to maintain balance of redox state. Changes in sleep patterns have been reported alter this function, leading changes disease susceptibility or behavior. Here, we recruited healthy male physicians measured extent effect overnight deprivation (SD) recovery (RS) on nociceptive thresholds systemic (plasma-derived) metabolism, namely, major glutathione (GSH), catalase (CAT), malondialdehyde (MDA),...
To investigate the dose-response relationship and synergetic effect of maternal educational level two measures prenatal care on neonatal low birth weight (LBW) risk.Data were derived from Perinatal Health Care Surveillance System (PHCSS) January 2001 to September 2009 in Kunshan City, Jiangsu province, eastern China, which included data 31412 women with a normal delivery 640 LBW delivery. Logistic modelling was performed estimate association including joint effects odds ratio (OR) 95%...
Acute pulmonary embolism (APE) can be life-threatening. Early detection is even more difficult for patients under general anesthesia as common symptoms are not available and the pathophysiological course of intra-operative APE influenced by procedures surgery anesthesia, which makes a distinctive group. We report case during orthopedic anesthesia. A 64-year-old female with atrial fibrillation surgical history varicosity underwent total right hip replacement No arterial or deep vein...
Eosinophil infiltration is considered a hallmark in allergic airway inflammation, and the blockade of eosinophil differentiation may be an effective approach for treating eosinophil-related disorders. Mammalian target rapamycin (mTOR) vital modulator cell growth control related diseases, we have recently demonstrated that can suppress inflammation. Considering its critical role haematopoiesis, further investigated mTOR context asthmatic pathogenesis. Intriguingly, inhibition mTOR, either by...
The relationship between brain structure alteration and metabolic product clearance after night shift work with total sleep deprivation (SD) remains unclear. Twenty-two intensive care unit staff on regularly rotating were implemented structural diffusion MRI under both rest wakefulness (RW) SD conditions. Peripheral blood samples collected for the measurement of cerebral metabolites. Voxel-based morphometry tensor imaging analysis used to investigate alterations in gray matter density (GMD)...
Objective. To investigate the differences in awareness, knowledge, and management of osteoporosis from a cohort medical staff after educational intervention. Methods. A total 653 workers different departments related to prevention treatment 7 hospitals Ningxia were enrolled. Information was collected using designed questionnaire. Results. After 5 years intervention follow-up, had an increased understanding diagnosis, including dual-energy X-ray, ultrasound bone sonometer, fragility fracture...
Chemotherapy treatment based on Cisplatin (CDDP) is established as the drug of choice for head and neck squamous cell carcinoma (HNSCC). Malignant tumors respond to microenvironment alteration through a dynamic balance mitochondrial fission fusion. HNSCC known have hypoxic conditions, yet effects underlying mechanisms hypoxia chemosensitivity dynamics remain unclear. We found that promoted CDDP sensitivity in cells. Importantly, Mff was shown be correlated with clinical samples underwent...
Objective: To explore the efficacy of CT guided local injection methylprednisolone in treatment percutaneous punctured bone eosinophilic granuloma. Methods: A total 15 cases granuloma underwent puncture biopsy from September 2009 to July 2016 our hospital. With pathologically confirmed diagnosis, these patients received sodium succinate therapy. The outcomes were followed up and evaluated based on Neer Chigira healing evaluation standard. Results: After 1 month treatment,...