A5100325768- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Osteoarthritis Treatment and Mechanisms
- Bone Tumor Diagnosis and Treatments
- Bone and Dental Protein Studies
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- Antimicrobial Peptides and Activities
- Chemokine receptors and signaling
- interferon and immune responses
- ZnO doping and properties
- IL-33, ST2, and ILC Pathways
- Gas Sensing Nanomaterials and Sensors
- GDF15 and Related Biomarkers
- Pelvic floor disorders treatments
- Neonatal Respiratory Health Research
- Mast cells and histamine
- Musculoskeletal synovial abnormalities and treatments
- Pancreatic and Hepatic Oncology Research
- Anorectal Disease Treatments and Outcomes
- Oral and Maxillofacial Pathology
- Folate and B Vitamins Research
- Pediatric health and respiratory diseases
- CAR-T cell therapy research
Second Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Anhui University
2024-2025
Second Affiliated Hospital of Zhejiang University
2016-2025
First Affiliated Hospital of Jiangxi Medical College
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Shanxi Medical University
2018-2023
Fudan University
2022
Hunan University
2022
Huashan Hospital
2022
Abstract Biased signaling of G protein-coupled receptors describes an ability different ligands that preferentially activate alternative downstream pathway. In this work, we identified and characterized N-terminal truncations endogenous chemokine CCL15 as balanced or biased agonists targeting CCR1, presented three cryogenic-electron microscopy structures the CCR1–G i complex in ligand-free form bound to with a resolution 2.6–2.9 Å, illustrating structural basis natural initiates inflammation...
Abstract Chemokine receptors are a family of G-protein-coupled with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures two human CC chemokine receptor–G-protein complexes: CCR2 bound to its endogenous ligand CCL2, CCR3 the apo state. The structure CCL2–CCR2–G-protein complex reveals that CCL2 inserts deeply into extracellular half transmembrane domain, forms substantial interactions receptor through most N-terminal glutamine....
Eosinophils primarily secrete CCL6 to promote tumor cell migration and metastasis formation.
Abstract Eosinophils are terminally differentiated cells derived from hematopoietic stem (HSCs) in the bone marrow. Several studies have confirmed effective roles of eosinophils asthmatic airway pathogenesis. However, their regulatory functions not been well elucidated. Here, increased C-C chemokine ligand 6 (CCL6) mice and human orthologs CCL15 CCL23 that highly expressed asthma patients described, which mainly eosinophils. Using Ccl6 knockout mice, further revealed CCL6-dependent allergic...
Acute lung injury (ALI) is a fatal but undertreated condition with severe neutrophilic inflammation, although little known about the functions of eosinophils in pathogenesis ALI. Our objectives were to investigate roles and molecular mechanisms ALI.Pulmonary identified by flow cytometry. Mice abundant or deficient used. Cellularity neutrophils bronchoalveolar lavage fluid, inflammatory assessment, survival rate determined. Human samples also used for validating experimental results.Blood...
Abstract Eosinophils play a crucial role as effector cells in asthma pathogenesis, with their differentiation being tightly regulated by metabolic mechanisms. While the involvement of iron various cellular processes is well known, its specific eosinophil has largely remained unexplored. This study demonstrates that levels are increased during process from progenitors to mature and activated eosinophils context allergic airway inflammation. Through experiments involving chelators,...
To observe the clinical efficacy of Tongtiao acupuncture-moxibustion method for long COVID-19 olfactory dysfunction. A total 28 patients with dysfunction were selected and treated therapy (regulating orifices, invigorating brain, regulating qi blood). Acupoints included Yintang (GV24+), Baihui (GV20), Fengfu (GV16), Qihai (CV6) bilateral Yingxiang (LI20), Fengchi (GB20), Xuehai (SP10), Zusanli (ST36). Deep needling to periosteum nasal bone was performed at (EX-HN3), warming needle...
Abstract Aberrant expression of transforming growth factor‐β1 (TGF‐β1) is associated with renal cell carcinoma (RCC) progression by inducing cancer metastasis. However, the downstream effector(s) in TGF‐β signaling pathway not fully characterized. In present study, elevation secreted protein acidic and rich cysteine (SPARC) as a regulated gene RCC was identified applying differentially expressed analysis microarray analysis, we further confirmed this result several lines. Clinically, these...
Severe eosinophilic asthma (SEA) is a therapy-resistant respiratory condition with poor clinical control. Treatment efficacy and patient compliance of current therapies remain unsatisfactory. Here, inspired by the remarkable success chimeric antigen receptor-based cellular adoptive immunotherapies demonstrated for treatment variety malignant tumors, we engineered cytokine-anchored receptor T (CCAR-T) cell system using IL-5-CD28-CD3ζ to trigger T-cell-mediated killing eosinophils that are...
The nuclear factor κB (NF-κB) pathway plays essential roles in innate and adaptive immunity, but little is known how NF-κB signaling compartmentalized spatiotemporally activated the cytoplasm. Here, we show that lipogenesis signal cascade Scap-SREBP1-S1P/S2P orchestrates homeostasis spatiotemporal activation of NF-κB. SREBP cleavage-activating protein (Scap) sterol regulatory element-binding 1 (SREBP1) form a super complex with inhibitors α (IκBα) to associate close endoplasmic reticulum...
Eosinophils (Eos) have been long considered as end-stage effector cells in the hierarchical hematopoietic system. Numerous lines of evidence suggested that Eos are multifunctional leukocytes with respect to initiation, propagation and regulation various inflammatory or immune reactions, especially allergic diseases. Recent studies shown also required for maintenance bone marrow plasma differentiation B cells. However, it remains unclear whether contributes stem cell (HSC) homeostasis. Here,...
Osteoarthritis (OA), a prevalent degenerative joint disease, significantly affects the well-being of afflicted individuals and compromises standard functionality human joints. The emerging biomarker, Cartilage acidic protein 1 (CRTAC1), intricately associates with OA initiation serves as prognostic indicator for trajectory toward replacement. However, existing diagnostic methods CRTAC1 are hampered by limited abundance, thus restricting precision specificity. Herein, novel approach utilizing...
Eosinophil infiltration is considered a hallmark in allergic airway inflammation, and the blockade of eosinophil differentiation may be an effective approach for treating eosinophil-related disorders. Mammalian target rapamycin (mTOR) vital modulator cell growth control related diseases, we have recently demonstrated that can suppress inflammation. Considering its critical role haematopoiesis, further investigated mTOR context asthmatic pathogenesis. Intriguingly, inhibition mTOR, either by...
The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase DNA bridges in mitosis along with a complex of repair proteins. Previous studies show PICH deficiency-induced embryonic lethality mice. However, the function that is required suppress PICH-deficient mammals remains be determined. clinical suggest link between deficiency and onset acquired aplastic anemia. Here, using Pich knock-out (KO) mouse models, authors provide evidence for mechanistic defective...
Idiopathic pulmonary fibrosis (IPF) is a distressing lung disorder with poor prognosis and high mortality rates. Limited therapeutic options for IPF major clinical challenge. Well-known its anti-apoptotic properties, B-cell lymphoma 2 (Bcl-2) plays critical role in the pathology of malignancies inflammatory diseases, including IPF. In this study, we aimed to investigate effect Bcl-2 homology domain 3 mimetic inhibitor, ABT-199, on bleomycin (BLM)-induced mice, explore possible underlying...
Eosinophils, basophils, white blood cells (WBC), and immunoglobulin E (IgE) play major roles in the pathogenesis of atopic dermatitis (AD), bullous pemphigoid (BP), drug reaction with eosinophilia systemic symptoms (DRESS), hypereosinophilic syndrome (HES). This study aimed to describe these parameters different skin diseases provide further information concerning underlying pathogenesis.A cross-sectional test results, including WBC count, peripheral eosinophil basophil/WBC percentage, IgE...
The inflammatory cascade can be initiated with the recognition of damaged DNA. Macrophages play an essential role in particulate matter (PM)-induced airway inflammation. In this study, we aim to explore PM induced DNA damage response macrophages and its function were assessed using bone marrow-derived following treatment mouse model instilled intratracheally PM. We found that significant both vitro vivo simultaneously triggered a rapid response, represented by nuclear RPA, 53BP1 γH2AX foci...
Objective To provide an overview of the current knowledge growth-differentiation factor 15 (GDF-15) in heart disease. Data sources identify relevant publications, we searched PubMED database combining textual terms heart, cardiac, cardiovascular disease with GDF-15. Study selection Well-controlled, relatively large-scale, retrospective studies as well meaningful individual cases were all selected materials. Results GDF-15 is a distant member transforming growth factor-β cytokine superfamily....