A5000212566- Intracranial Aneurysms: Treatment and Complications
- Neuroscience and Neural Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Hemoglobin structure and function
- Erythrocyte Function and Pathophysiology
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Liver Disease Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Heart Rate Variability and Autonomic Control
- Moyamoya disease diagnosis and treatment
- Liver Diseases and Immunity
- Nuclear Physics and Applications
- Wound Healing and Treatments
- Spinal Fractures and Fixation Techniques
- Gaze Tracking and Assistive Technology
- Differential Equations and Numerical Methods
- Heme Oxygenase-1 and Carbon Monoxide
- Hemostasis and retained surgical items
- Metamaterials and Metasurfaces Applications
- Thermoregulation and physiological responses
General Hospital of Shenyang Military Region
2021-2024
University of Maryland, Baltimore
2020-2024
Johns Hopkins University
2014-2023
Fuzhou University
2023
Institute for Forecasting of the Slovak Academy of Sciences
2023
Cytoskeleton (United States)
2023
Dalian University of Technology
2023
City Institute, Dalian University of Technology
2023
Johns Hopkins Medicine
2014-2023
China Medical University
2021-2023
Nonmanual human-machine interfaces (HMIs) have been studied for wheelchair control with the aim of helping severely paralyzed individuals regain some mobility. The challenge is to rapidly, accurately, and sufficiently produce commands, such as left right turns, forward backward motions, acceleration, deceleration, stopping. In this paper, a novel electrooculogram (EOG) based HMI proposed control.A total 13 flashing buttons, each which corresponds command, are presented in graphical user...
Wirelessly powered implants are increasingly being developed to interface with neurons in the brain. They often rely on microelectrode arrays, which limited by their ability cover large cortical surface areas and long-term stability because of physical size rigid configuration. Yet some clinical research applications prioritize a distributed neural over one that offers high channel count. One solution make scale, fully specifiable, electrical stimulation/recording possible, is disconnect...
Abstract Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical to brain function, dysregulated in neuropathologies such as tumors. Interrogating these phenomena freely behaving animals requires a portable microscope with multiple optical contrast mechanisms. Therefore, we developed miniaturized with: fluorescence (FL) channel for imaging neural activity (e.g., GCaMP) or fluorescent cancer cells 9L-GFP); an intrinsic signal (IOS) hemoglobin absorption (i.e.,...
The key issue of electroencephalography (EEG)-based brain switches is to detect the control and idle states in an asynchronous manner. Most existing methods rely on a threshold. However, it often time consuming select satisfactory threshold, chosen threshold might be inappropriate over long period due variability EEG signals. This paper presents new P300-based threshold-free switch. Specifically, one target button three pseudo buttons, which are intensified random order produce P300...
Abstract Sepsis is a major cause of mortality, and dysregulation the immune response plays central role in this syndrome. H2S, recently discovered gaso-transmitter, endogenously generated by many cell types, regulating number physiologic processes pathophysiologic conditions. We report that H2S increased survival after experimental sepsis induced cecal ligation puncture (CLP) mice. Exogenous decreased systemic inflammatory response, reduced apoptosis spleen, accelerated bacterial...
An implant that can electrically stimulate neurons across different depths and regions of the brain currently does not exist as it poses a number obstacles need to be solved. In order address challenges, this paper presents concept "microbead," fully integrated wirelessly powered neural device allows for spatially selective activation tissue. The prototype chip is fabricated in 130-nm CMOS technology measures 200 μm × μm, which represents smallest remotely stimulator date. system validated...
This study proposes an event-related potential (ERP) BCI-based environmental control system that integrates household electrical appliances, a nursing bed, and intelligent wheelchair to provide daily assistance paralyzed patients with severe spinal cord injuries (SCIs).An asynchronous mode is used switch the on or off select device (e.g., TV) for achieving selfpaced control. In mode, we introduce several pseudo-keys verification mechanism effectively reduce false operation rate. By contrast,...
Introduction: Coronavirus disease 2019 (COVID-19) is characterized by impaired oxygen (O 2 ) homeostasis, including O sensing, uptake, transport/delivery, and consumption. Red blood cells (RBCs) are central to maintaining homeostasis undergo direct exposure coronavirus in vivo . We thus hypothesized that COVID-19 alters RBC properties relevant the hematological profile, Hb transport characteristics, rheology, hypoxic vasodilatory (HVD) reflex. Methods: RBCs from 18 hospitalized subjects 20...
A facile synthesis strategy of multi-component functional synergy absorbers with a minimum reflection loss value (RL min ) −51.74 dB at only 1.9 mm (11.12 GHz) and the efficient absorption bandwidth (EAB) 4.28 GHz 1.4 mm.
An 8-channel current steerable, multi-phasic neural stimulator with on-chip DAC calibration and residue nulling for precise charge balancing is presented. Each channel consists of two sub-binary radix DACs followed by wide-swing, high output impedance buffers providing time-multiplexed source sink outputs anodic cathodic stimulation. A single integrator shared among channels serves to calibrate coefficients closely match the stimulation phases. Following calibration, differential...
We present a bidirectional neural interface with 4-channel biopotential analog-to-digital converter (bioADC) and current-mode stimulator in 180 nm CMOS. The bioADC directly transduces microvolt biopotentials into digital representation without voltage-amplification stage. Each channel comprises continuous-time first-order <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\Delta...
Abstract Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism communication gastric cancer remains largely unclear. Here, we found that patients with GC showed a significantly higher mast cell infiltration tumors. levels increased progression independently predicted reduced overall survival. Tumor-derived adrenomedullin (ADM) induced degranulation via PI3K-AKT signaling pathway, which...
Laboratory and clinical studies have demonstrated that therapeutic hypothermia (TH), when applied as soon possible after resuscitation from cardiac arrest (CA), results in better neurological outcome. This study tested the hypothesis TH would promote cerebral blood flow (CBF) restoration its maintenance return of spontaneous circulation (ROSC) CA. Twelve Wistar rats resuscitated 7-min asphyxial CA were randomized into two groups: group (7 H, n = 6), treated with mild (33–34℃) immediately...
Recently, increasing attention has been paid to the role of Squalene epoxidase (SQLE) in several types cancers. However, its functional tumor progression head and neck squamous cell carcinoma (HNSCC) is still unclear. We performed bioinformatic analyses relative experiments assess potential mechanism SQLE-mediated HNSCC malignancy. And results showed that SQLE was significantly upregulated samples compared with peritumor samples. Mechanistically, miR-584-5p downregulation may lead...
Cardiac arrest (CA) entails significant risks of coma resulting in poor neurological and behavioral outcomes after resuscitation. Significant subsequent morbidity mortality post-CA patients are largely due to the cerebral cardiac dysfunction that accompanies prolonged whole-body ischemia syndrome (PCAS). PCAS results strong inflammatory responses including neuroinflammation response leading outcome. Currently, there no proven neuroprotective therapies improve apart from therapeutic...
Ischemic stroke is a leading cause of mortality and permanent disability, with enormous financial repercussions on health systems worldwide. brain injury results from complex sequence pathophysiological events that evolve over time. In order to examine the molecular mechanisms underlying middle cerebral artery occlusion (MCAO)‑induced ischemic stroke, GSE35338 affymetrix microarray data was obtained Gene Expression Omnibus database differentially expressed genes (DEGs) between samples...
Chronically monitoring cerebral activities in awake and freely moving status is very important physiological pathological studies.We present a novel standalone micro-imager for the blood flow (CBF) total hemoglobin (HbT) animals using laser speckle contrast imaging (LSCI) optical intrinsic signal (OIS) methods.A new cranial window method, contact lens wide field optics, also proposed to achieve chronic wide-field of rat's cortex.The hemodynamic rats' cortex were measured first time without...