A5067819231- Vagus Nerve Stimulation Research
- Gastrointestinal motility and disorders
- Heart Rate Variability and Autonomic Control
- Pain Management and Treatment
- Cardiac Arrest and Resuscitation
- Neurogenesis and neuroplasticity mechanisms
- Aldose Reductase and Taurine
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pluripotent Stem Cells Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Heme Oxygenase-1 and Carbon Monoxide
- EEG and Brain-Computer Interfaces
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Health and Development
- Autophagy in Disease and Therapy
- Gastroesophageal reflux and treatments
- Menstrual Health and Disorders
- Calcium signaling and nucleotide metabolism
- Signaling Pathways in Disease
- Neurological Disorders and Treatments
Johns Hopkins Medicine
2015-2025
Johns Hopkins University
2015-2025
Florida Atlantic University
2013-2017
National University of Singapore
2016
University of Baltimore
2014
Tarbiat Modares University
2010
In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining balance among demyelination, neurodegeneration, myelin repair. Phagocytic regenerative functions of these CNS innate immune cells support remyelination, whereas chronic maladaptive inflammatory activation promotes lesion expansion disability, particularly progressive forms MS. No currently approved drugs convincingly target CNS, contributing to lack therapies...
Induced pluripotent stem (iPS) cells are at the forefront of research in regenerative medicine and envisaged as a source for personalized tissue repair cell replacement therapy. Here, we demonstrate first time that oligodendrocyte progenitors (OPs) can be derived from iPS generated using either an episomal, non-integrating plasmid approach or standard integrating retroviruses survive differentiate into mature oligodendrocytes after early transplantation injured spinal cord. The efficiency OP...
Abstract The cellular-level effects of low/high frequency oscillating magnetic field on excitable cells such as neurons are well established. In contrast, the a homogeneous, static (SMF) Central Nervous System (CNS) glial less investigated. Here, we have developed an in vitro SMF stimulation set-up to investigate genomic exposure oligodendrocyte differentiation and neurotrophic factors secretion. Human oligodendrocytes precursor (OPCs) were stimulated with moderate intensity (0.3 T) for...
Sacral nerve stimulation (SNS) was reported to improve 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. The aim of this study investigate whether the SNS anti-inflammatory effect is mediated via local sacral splanchnic or spinal afferent-vagal efferent-colon pathway. Under general anesthesia, rats were administrated with TNBS intrarectally, and bipolar electrodes implanted unilaterally at S3. vagal nerves severed different locations for assessment neural 10 days improved...
A technology capable of high-resolution, label-free imaging subtle pathology in vivo during colonoscopy is imperative for the early detection disease and performance accurate biopsies. While colonoscopic OCT has been developed to visualize colonic microstructures beyond mucosal surface, its clinical potential remains limited by sub-optimal resolution (∼6.5 µm tissue), inadequate contrast, a lack high-resolution criteria lesion detection. In this study, we an ultrahigh-resolution (UHR)...
The mucosal barrier damage is recognized as one of the key factors in pathogenesis colitis. While sacral nerve stimulation (SNS) was reported to have therapeutic potential for colitis, its mechanisms actions on colonic permeability remained largely unknown.In this study, colitis induced by intrarectal administration TNBS rats. Five days later, they were treated with SNS or sham-SNS 10 days. effects assessed measuring expression tight-junction proteins involved regulating and FITC-dextran...
Sacral nerve stimulation (SNS) has been employed for treating constipation. However, its mechanisms involving enteric nervous system (ENS) and motility are largely unknown. In this study, we investigated the possible ENS involvement of SNS in Loperamide-induced constipation rats.Experiment-1 was designed to study effects acute on whole colon transit time (CTT). experiment-2, induced by Loperamide then applied daily or sham-SNS 1 week. Choline acetyltransferase (ChAT), nitric oxide synthase...
Protein kinase C (PKC) plays a key role in modulating the activities of innate immune cells central nervous system (CNS). A delicate balance between pro-inflammatory and regenerative by microglia CNS-associated macrophages is necessary for proper functioning CNS. Thus, maladaptive activation these CNS results neurodegeneration demyelination associated with various neurologic disorders, such as multiple sclerosis (MS) Alzheimer’s disease. Prior studies have demonstrated that modulation PKC...
Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS). Although classically considered demyelinating disease, neuroaxonal injury occurs in both acute and chronic phases represents pathologic substrate disability not targeted by current therapies. Nitric oxide (NO) generated CNS macrophages microglia contributes to all MS, but candidate therapies that prevent NO-mediated have been identified. Here, we demonstrate multifunctional protein...
Abstract In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining balance between myelin repair demyelination/neurodegeneration. Phagocytic regenerative functions of these CNS innate immune cells support remyelination, whereas chronic maladaptive inflammatory activation promotes lesion expansion disability, particularly progressive forms MS. No currently approved drugs convincingly target CNS, contributing to critical...
Abstract Objective There is a complex interaction between nervous and cardiovascular systems, but sparse data exist on brain–heart electrophysiological responses to cardiac arrest resuscitation. Our aim was investigate dynamic changes in autonomic cortical function during hyperacute stage post‐resuscitation. Methods Ten rats were resuscitated from 7‐min arrest, as indicators of response, heart rate (HR), its variability (HRV) measured. HR monitored through continuous electrocardiography,...
Cardiac arrest (CA), the sudden cessation of effective cardiac pumping function, is still a major clinical problem with high rate early and long-term mortality. Post-cardiac syndrome (PCAS) may be related to an systemic inflammatory response leading exaggerated sustained neuroinflammation. Therefore, intervention targeted drug delivery attenuate neuroinflammation greatly improve therapeutic outcomes. Using clinically relevant asphyxia CA model, we demonstrate that single (i.p.) dose...
Bone marrow stromal cells (BMSCs) are multipotent and can be induced to differentiate into different lineages including osteogenic, chondrogenic, myogenic neuronal phenotypes. BMSCs were reported a suitable option for regenerative medical research. In this study, GABAergic phenotypes using beta-mercaptoethanol (betaME) retinoic acid (RA) as preinducers followed by potassium chloride inducer, evaluated fibronectin Oct-4. The percentages of immunoreactive nestin, neurofilaments (NF 68, NF 160,...
Abstract Patients with ulcerative colitis are typically suspected of an inflammatory flare based on suggestive symptoms inflammation. The aim this study was to evaluate the impact inflammation colonic motility and rectal sensitivity from active recovery Male rats were given drinking water 5% dextran sulfate sodium for 7 days. Inflammation, intestinal motor sensory functions investigated weekly 6 weeks. (1) disease activity index score, fecal calprotectin tumor necrosis factor alpha increased...
Cardiac arrest (CA) remains the leading cause of coma, and early arousal recovery indicators are needed to allocate critical care resources properly. High-frequency oscillations (HFOs) somatosensory evoked potentials (SSEPs) have been shown indicate responsive wakefulness days following CA. Nonetheless, their potential in acute phase, where injury is reversible, has not tested. We hypothesize that time-frequency (TF) analysis HFOs can determine phase. To test our hypothesis, eleven adult...
Gastroparesis is commonly seen in patients with diabetes and functional dyspepsia no satisfactory therapies. Dysautonomia one of the main reasons for imbalanced motility. We hypothesized that spinal cord stimulation (SCS) a viable therapy gastroparesis via autonomic modulation to improve gastric The aim find an optimal method SCS treating gastroparesis.Eight healthy-female dogs were implanted cannula, duodenal 2 multi-electrode leads, implantable pulse generator. Gastric motility index (MI)...