A5037542128- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Polymer Nanocomposites and Properties
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Polymer crystallization and properties
- Conducting polymers and applications
- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Retinal Diseases and Treatments
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Polymer composites and self-healing
- Click Chemistry and Applications
- Electrospun Nanofibers in Biomedical Applications
- Chemical Synthesis and Analysis
- Retinal and Optic Conditions
- Electromagnetic wave absorption materials
- Nanoplatforms for cancer theranostics
- Protein Structure and Dynamics
- Immunotherapy and Immune Responses
- Curcumin's Biomedical Applications
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Histone Deacetylase Inhibitors Research
Johns Hopkins University
2017-2025
Abeona Therapeutics (United States)
2020-2025
Johns Hopkins Medicine
2017-2025
Washington State University
2024
National Institute of Technology Rourkela
2023
Buck Institute for Research on Aging
2020-2021
University of Baltimore
2020
Johns Hopkins Hospital
2020
Cleveland Clinic
2018
National Eye Institute
2018
Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed translate into clinical success due their nonspecific cellular localization, poor transport properties across multiple biological barriers, and side effects. These challenges, coupled the complex function mitochondria, create need for innovative strategies. Methods: Neutral hydroxyl-terminated polyamidoamine...
Curcumin, a yellow bioactive component of Indian spice turmeric, is known to have wide spectrum biological applications. In spite various astounding therapeutic properties, it lacks in bioavailability mainly due its poor solubility water. this work, we conjugated curcumin with silica nanoparticles improve aqueous and hence make more bioavailable. Conjugation loading was further examined transmission electron microscope (TEM) thermogravimetric analyzer. Cytotoxicity analysis synthesized...
Brain-related disorders have outmatched cancer and cardiovascular diseases worldwide as the leading cause of morbidity mortality. The lack effective therapies relatively dry central nervous system (CNS) drug pipeline pose formidable challenge. Superior, targeted delivery current clinically approved drugs may offer significant potential. Minocycline has shown promise for treatment neurological owing to its ability penetrate blood-brain barrier (BBB) potency. Despite potential in clinic...
Impairments of mitochondrial functions have been associated with failure cellular in different tissues, leading to various pathologies. We report here a mitochondria-targeted nanodelivery system for coenzyme Q10 (CoQ10) that can reach mitochondria and deliver CoQ10 adequate quantities. Multifunctional nanocarriers based on ABC miktoarm polymers (A = poly(ethylene glycol (PEG), B polycaprolactone (PCL), C triphenylphosphonium bromide (TPPBr)) were synthesized using combination click chemistry...
PEGOL-60, a ligand-free high hydroxyl surface density dendrimer, targets neuroinflammation from systemic administration.
Abstract Background In Alzheimer’s disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the pathogenesis of disease. Identifying approaches specifically target plaque-associated (PAMs) without interfering in homeostatic functions non-plaque associated would afford powerful tool potential therapeutic avenue. Methods Here, we demonstrated that systemically administered nanomedicine, hydroxyl dendrimers (HDs), can cross blood brain...
We report herein a novel “onion peel strategy” for the divergent construction of glycodendrimers using different building blocks at each layer dendritic growth.
Both convergent and divergent strategies for the synthesis of “onion peel” glycodendrimers are reported which resulted in one best multivalent ligands known against virulent factor from a bacterial lectin isolated <italic>Pseudomonas aeruginosa</italic>.
Dendrimer-N-acetyl cysteine (D-NAC) conjugate has shown significant promise in multiple preclinical models of brain injury and is undergoing clinical translation. D-NAC a generation-4 hydroxyl-polyamidoamine dendrimer where N-acetyl (NAC) covalently bound through disulfide linkages on the surface dendrimer. It remarkable potential to selectively target deliver NAC activated microglia astrocytes at site several animal models, producing improvements neurological outcomes fraction free drug...
Glioblastoma exhibits high mortality rates due to challenges with drug delivery the brain and into solid tumors. This two-pronged barrier necessitates doses of systemic therapies, resulting in significant off-target toxicities. Recently, dendrimer-nanomedicines (without ligands) have shown promise for targeting specific cells tumors from circulation, improved efficacy amelioration A dendrimer–rapamycin conjugate (D-Rapa) is presented here that specifically targets tumor-associated...
Traumatic corneal injuries are a leading cause of blindness among military personnel. These need immediate attention at the combat zone, but treatment options limited as life-saving measures often prioritized. To address this critical gap, we have developed Ocupair, two-component hydrogel system that consists (i) an injectable viscoelastic filler stabilizes ocular cavity and prevents hypotony. (ii) An in-situ photo-curable adhesive comprising methacrylated PAMAM dendrimer hyaluronic acid...
Abstract Traumatic corneal injuries are a leading cause of blindness among military personnel. These need immediate attention in the combat zone, but treatment options limited as life‐saving measures often prioritized. To address this critical gap, we have developed OcuPair TM , two‐component hydrogel system that consists i) an injectable viscoelastic filler stabilizes ocular cavity and prevents hypotony. ii) An situ photo‐curable adhesive comprising methacrylated, hydroxyl PAMAM dendrimer...
Mechanical properties of polypropylene and SEBS-g-MA copolymer blends up to volume fraction 0.5 are evaluated. Tensile impact strength described correlated with theoretical models. Crystallinity on which depend decreases increasing concentrations copolymer. modulus decreased but tensile elongation enhanced. Morphological studies show good dispersion in a weak level interaction between the phases.
Cognitive impairment is a common aspect of multiple sclerosis (MS) for which there are no treatments. Reduced brain N-acetylaspartylglutamate (NAAG) levels linked to impaired cognition in various neurological diseases, including MS. NAAG regulated by glutamate carboxypeptidase II (GCPII), hydrolyzes the neuropeptide N-acetyl-aspartate and glutamate. GCPII activity upregulated multifold microglia following neuroinflammation. Although several inhibitors, such as 2-PMPA, elevate restore...
Retinal microglial/macrophage activation and optic nerve (ON) are glaucoma biomarkers potential therapeutic targets for this blinding disease. We report targeting of activated microglia by PAMAM dendrimers in a rat model neuroprotection N-acetylcysteine-conjugated dendrimer (D-NAC) conjugates post-injury rescue experiment. Intravitreally delivered fluorescently labeled (D-Cy5) targeted were retained Iba-1-positive cells (90% at 7 days 55% after 28 days) the retina following intraocular...
A novel strategy is described for the rapid syntheses of polyhydroxylated dendrimers in which layer by building blocks are different from one another. The resulting showed no cytotoxicity.