A5036872139- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Calcium signaling and nucleotide metabolism
- Biomarkers in Disease Mechanisms
- Pain Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Apelin-related biomedical research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
Johns Hopkins University
2014-2024
Johns Hopkins Medicine
2023-2024
Protein kinase C (PKC) plays a key role in modulating the activities of innate immune cells central nervous system (CNS). A delicate balance between pro-inflammatory and regenerative by microglia CNS-associated macrophages is necessary for proper functioning CNS. Thus, maladaptive activation these CNS results neurodegeneration demyelination associated with various neurologic disorders, such as multiple sclerosis (MS) Alzheimer’s disease. Prior studies have demonstrated that modulation PKC...
Abstract In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining balance between myelin repair demyelination/neurodegeneration. Phagocytic regenerative functions of these CNS innate immune cells support remyelination, whereas chronic maladaptive inflammatory activation promotes lesion expansion disability, particularly progressive forms MS. No currently approved drugs convincingly target CNS, contributing to critical...
Protein kinase C (PKC) plays a key role in modulating the activities of innate immune cells central nervous system (CNS). A delicate balance between pro-inflammatory and regenerative by microglia CNS-associated macrophages is necessary for proper functioning CNS. Thus, maladaptive activation these CNS results neurodegeneration demyelination associated with various neurologic disorders, such as multiple sclerosis (MS) Alzheimer's disease. Prior studies have demonstrated that modulation PKC...
Tissue-resident memory T (T RM ) cells preferentially reside in peripheral tissues, serving as key players tumor immunity and immunotherapy. The lack of effective approaches for expanding delivering these vivo hinders the exploration cell–mediated cancer Here, we report a nanoparticle artificial antigen-presenting cell (nano-aAPC) ex expansion approach an delivery system cells. Using nano-aAPC platform, expanded functional antigen-specific murine human -like CD8 + vivo. We also developed...