A5100668683- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Immune cells in cancer
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- interferon and immune responses
- Immune responses and vaccinations
- Autoimmune and Inflammatory Disorders Research
- Nerve injury and regeneration
- Computational Drug Discovery Methods
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Treatment of Major Depression
- Advanced Glycation End Products research
- Muscle Physiology and Disorders
- Genetics and Neurodevelopmental Disorders
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2023-2025
Georgetown University
2019-2025
Chengdu University of Traditional Chinese Medicine
2022-2023
Washington Center
2023
In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining balance among demyelination, neurodegeneration, myelin repair. Phagocytic regenerative functions of these CNS innate immune cells support remyelination, whereas chronic maladaptive inflammatory activation promotes lesion expansion disability, particularly progressive forms MS. No currently approved drugs convincingly target CNS, contributing to lack therapies...
Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. However, the role endogenously synthesized on CNS development function remains poorly understood. Here, magnetic resonance spectroscopy adult mouse brains from both sexes revealed synthesis dependent expression enzyme, guanidinoacetate methyltransferase (GAMT). To identify Gamt -expressed cells, how affects postnatal development, we...
Abstract Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS). Here, we show aromatic alpha-keto acids (AKAs) generated from the amino acid oxidase, interleukin-4 induced 1 (IL4I1), promote efficient remyelination mouse models MS. During remyelination, cells upregulated expression IL4I1. Conditionally knocking out IL4I1 impaired efficiency. Mice lacking exhibited a reduction AKAs,...
Rosmarinic acid (RA), a natural phenolic compound with variety of bioactive properties. However, the antidepressant activity and mechanism RA remain unclear. The aim this study is to investigate effects potential mechanisms on chronic CORT injection induced depression-like behavior in mice. Male C57BL/6 J mice were intraperitoneally injected (10 mg/kg) orally given daily or 20 for 21 consecutive days. In vitro, HT22 cells exposed (200 μM) (12.5, 25 50 LY294002 (a PI3K inhibitor) ANA-12 TrkB...
ABSTRACT Multiple sclerosis (MS) is a chronic inflammatory disease characterized by immune‐mediated demyelination of the central nervous system, resulting in extensive neurological deficit and remyelination impairment. We have previously found that interleukin‐four induced one (IL4I1) protein modulates CNS inflammation enhances mouse models experimental demyelination. However, it remained unclear if IL4I1 regulates lymphocyte activity MS. To assess therapeutic potential MS, we investigated...
Significance To develop therapeutic strategies that enhance repair processes during central nervous system (CNS) injury, the molecular and cellular changes occurring at injury site must be determined. However, precisely isolating site, such as lesions in animal models of demyelination, has been difficult. We developed a simple powerful method to track analyze occur within lesion microenvironment over time. demonstrated neutral red-labeled could selectively isolated processed for detailed...
HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. normally localized to the nucleus, where it acts as chromatin associated non-histone binding protein. In contrast, extracellular an alarmin released by stressed cells act danger molecular pattern (DAMP). We have recently determined that progenitor from multiple sclerosis patients exhibit cellular senescent phenotype and release which directly impaired maturation of oligodendrocyte (OPCs) myelinating oligodendrocytes (OLs)....
While modern high efficacy disease modifying therapies have revolutionized the treatment of relapsing-remitting multiple sclerosis, they are less effective at controlling progressive forms disease. Meningeal inflammation is a recognized risk factor for cortical grey matter pathology which can result in disabling symptoms such as cognitive impairment and depression, but mechanisms linking meningeal remain unclear. Here, we performed MRI-guided spatial transcriptomics mouse model autoimmune to...
Abstract In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining balance between myelin repair demyelination/neurodegeneration. Phagocytic regenerative functions of these CNS innate immune cells support remyelination, whereas chronic maladaptive inflammatory activation promotes lesion expansion disability, particularly progressive forms MS. No currently approved drugs convincingly target CNS, contributing to critical...
While modern high efficacy disease modifying therapies have revolutionized the treatment of relapsing-remitting multiple sclerosis, they are less effective at controlling progressive forms disease. Meningeal inflammation is a recognized risk factor for cortical gray matter pathology which can result in disabling symptoms such as cognitive impairment and depression, but mechanisms linking meningeal remain unclear. Here, we performed magnetic resonance imaging (MRI)-guided spatial...
While modern high efficacy disease modifying therapies have revolutionized the treatment of relapsing-remitting multiple sclerosis, they are less effective at controlling progressive forms disease. Meningeal inflammation is a recognized risk factor for cortical grey matter pathology which can result in disabling symptoms such as cognitive impairment and depression, but mechanisms linking meningeal remain unclear. Here, we performed MRI-guided spatial transcriptomics mouse model autoimmune to...
While modern high efficacy disease modifying therapies have revolutionized the treatment of relapsing-remitting multiple sclerosis, they are less effective at controlling progressive forms disease. Meningeal inflammation is a recognized risk factor for cortical gray matter pathology which can result in disabling symptoms such as cognitive impairment and depression, but mechanisms linking meningeal remain unclear. Here, we performed magnetic resonance imaging (MRI)-guided spatial...
Abstract While modern high efficacy disease modifying therapies have revolutionized the treatment of relapsing-remitting multiple sclerosis, they are less effective at controlling progressive forms disease. Meningeal inflammation is a recognized risk factor for cortical grey matter pathology which can result in disabling symptoms such as cognitive impairment and depression, but mechanisms linking meningeal remain unclear. Here, we performed MRI-guided spatial transcriptomics mouse model...
This paper aimed to explore the antidepressant effect of essential oil from Schizonepeta tenuifolia Briq.(EOST) on treatment depression and its mechanism by using a combination network pharmacology mouse model lipopolysaccharide(LPS)-induced depression. The chemical components in EOST were identified gas chromatography-mass spectrometer(GC-MS), 12 active selected as study objects. targets related obtained Traditional Chinese Medicines Systems Pharmacology(TCMSP) SwissTargetPrediction...
ABSTRACT Multiple sclerosis (MS) is a chronic inflammatory disease characterized by immune mediated demyelination of the central nervous system, resulting in extensive neurological deficit and remyelination impairment. We have previously found that interleukin-four induced one (IL4I1) protein modulates CNS inflammation enhances mouse models experimental demyelination. However, it remained unclear if IL4I1 regulates lymphocyte activity MS. To assess therapeutic potential MS, we investigated...