A5045679704- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Spinal Cord Injury Research
- RNA Interference and Gene Delivery
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- 3D Printing in Biomedical Research
- Anesthesia and Neurotoxicity Research
- Wound Healing and Treatments
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Virus-based gene therapy research
- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Retinal Development and Disorders
- Graphene and Nanomaterials Applications
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Vitamin C and Antioxidants Research
- Neonatal and fetal brain pathology
- Selenium in Biological Systems
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
Tarbiat Modares University
2014-2024
Tissue Dynamics (Israel)
2023
Khatam University
2012-2017
Shahid Sadoughi University of Medical Sciences and Health Services
2009
Bushehr University of Medical Sciences
2009
Baqiyatallah University of Medical Sciences
2009
Shahed University
2008
Poly-l-lysine-coated superparamagnetic iron oxide nanoparticles (SPIONs-PLL) were prepared and used as a novel-carrier for the transfer of brain-derived neurotrophic factor (BDNF) into neural stem cells (NSCs) under beneficial influence an external magnetic field. Pro-BDNF, gene from human brain cDNA libraries, was obtained by polymerase chain reaction constructed in mammalian expression vector (PSecTag2/HygroB). The (NPs) examined using Fourier transform infrared spectroscopy, zeta...
Polyethylene glycol hydrogel (PEG) conjugated with arginyl glycyl aspartic acid (RGD) (PEG–RGD) has been considered to be a scaffold in three-dimensional (3D) culture that improves neurite outgrowth; on the other hand, tenascin C controls neural growth and differentiation. In this study, effect of combined RGD mixture 3D (3D-PEG–RGD–TnC) survival, differentiation stem cells. The viability evaluated by live/dead assay results show NSCs 3D-PEG–RGD–TnC is significantly higher than its value...
Adult stem cells (ASC) are undifferentiated found throughout the body. These promising tools for cell replacement therapy in neurodegenerative disease. Adipose tissue is most abundant and accessible source of ASC. This study was conducted to evaluate effect selegiline on differentiation adipose-derived (ADSC) into functional neuron-like (NLC), also level neurotrophin expression differentiated cells.ADSC were transdifferentiated NLC using where CD90, CD49d, CD31, CD106 CD45 used as markers...
Temporal lobe epilepsy is one of the most common types epilepsy. Cytotherapy was tried for several neurological disorders. In this investigation, bone marrow stromal cells (BMSCs) were used in order to evaluate recovery epileptic rats induced by pilocarpine.The divided into four groups: a negative control, treated groups, and with vehicle only. The animals chronic phase monitored three weeks using Racine scale. BMSCs labeled BrdU injected intravenously. After 6 weeks, killed processed...
The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is histone deacetylase inhibitor. Acetylation histones critical cellular repair processes.In this study, rats were randomly assigned five experimental groups (laminectomy, untreated, three VPA-treated groups)....
The magnetic nanoparticle-based transfection method is a relatively new technique for delivery of functional genes to target tissues. We aimed evaluate the efficiency rat neural stem cell (NSC) using poly-L-lysine hydrobromide (PLL)-coated super paramagnetic iron oxide nanoparticles (SPION).The SPION was prepared and coated with PLL as agent evaluated in NSC enhanced green fluorescent protein-N1 plasmid containing GFP reporter gene. incubated 24 h culture media 25 µg/ml different...
Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively this purpose due their excellent biomedical-related properties. In study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) characterize the biocompatibility therapeutic efficacy of these fibers on treating full-thickness...
The nervous system has little capacity for self-repair after injury because neurons cannot proliferate owing to lack of suitable microenvironment. Therefore, neural tissue engineering that combines stem, scaffolds, and growth factors may improve the chance restoration damaged tissues. A favorable niche regeneration would be both fibrous electrically conductive scaffolds. Human Wharton jelly-derived mesenchymal stem cells were seeded on wet-electrospun 3D scaffolds composed poly lactic acid...
The complex process of spermatogenesis is regulated by various factors. In the present study, in vitro effects epidermal growth factor (EGF), follicle stimulating hormone (FSH) and testosterone on spermatogonial cell colony formation were investigated, best colonising was chosen for treating cells before transplantation. Sertoli isolated from neonatal mouse testes. identity confirmed through analysis morphology, alkaline phosphatase activity, immunoreactivity Co-cultured treated with EGF,...
The antiaging effect of selegiline was reported by several investigators; therefore, there is a growing interest in the potential use stem cell therapy aging. In this investigation, used to induce neuronal differentiation undifferentiated pluripotent embryonic cells (ESCs). results show that can phenotype associated with neurotrophic factor expression. Morphologic and immunohistochemical techniques were evaluate CCE cells, Cresyl violet for morphologic study, anti-synaptophysin antityrosine...