A5078064543- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Ultrasound Imaging and Elastography
- Muscle activation and electromyography studies
- Ultrasound and Hyperthermia Applications
- Heart Rate Variability and Autonomic Control
Washington University in St. Louis
2024
Johns Hopkins University
2022-2023
Johns Hopkins Medicine
2022-2023
Here we investigate the ability of low-intensity ultrasound (LIUS) applied to spinal cord modulate transmission motor signals.
Cardiac arrest (CA) remains the leading cause of coma, and early arousal recovery indicators are needed to allocate critical care resources properly. High-frequency oscillations (HFOs) somatosensory evoked potentials (SSEPs) have been shown indicate responsive wakefulness days following CA. Nonetheless, their potential in acute phase, where injury is reversible, has not tested. We hypothesize that time-frequency (TF) analysis HFOs can determine phase. To test our hypothesis, eleven adult...
Somatosensory evoked potentials (SEPs) are highly specific predictors of poor prognosis in hypoxic-ischemic coma when cortical responses (N20s) absent. However, bilateral N20 presence is nonspecific for good outcomes. High-frequency oscillations (HFOs) the SEP waveform predict neurologic recovery animals, but clinical applications poorly understood. We sought to develop a measure HFOs potentially improve detection outcomes coma.
Cardiac arrest (CA) is a public health crisis in the United States. CA results severely hypoxic insult to brain, damaging it and causing devastating neurological outcomes even after successful resuscitation. Here, we characterized cerebral vascular function post-CA as means of evaluating CA-induced brain injury. Specifically, using carefully developed experimental model that induced rodents via asphyxia, quantified metrics resistance (CVR) during first sixty minutes hyperemia following...