A5036956465- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Spinal Cord Injury Research
- AI in cancer detection
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Artificial Intelligence in Healthcare and Education
- Advanced Neural Network Applications
- Surgical Simulation and Training
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Spine and Intervertebral Disc Pathology
- Ultrasound Imaging and Elastography
- Prostate Cancer Diagnosis and Treatment
- Autopsy Techniques and Outcomes
- Transcranial Magnetic Stimulation Studies
- Cardiac and Coronary Surgery Techniques
- Microbial Inactivation Methods
- Acute Ischemic Stroke Management
- Algorithms and Data Compression
- Neuroscience and Neuropharmacology Research
- Medical Image Segmentation Techniques
- Nerve Injury and Rehabilitation
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
Johns Hopkins Medicine
2020-2023
Johns Hopkins University
2020-2023
Johns Hopkins Hospital
2021-2022
University of Pennsylvania
2022
National Institutes of Health Clinical Center
2016-2018
National Institutes of Health
2017
Prostate cancer (PCa) is the second most common cause of related deaths in men. Multiparametric MRI (mpMRI) accurate imaging method for PCa detection; however, it requires expertise experienced radiologists leading to inconsistency across readers varying experience. To increase inter-reader agreement and sensitivity, we developed a computer-aided detection (CAD) system that can automatically detect lesions on mpMRI use as reference. We investigated convolutional neural network based...
A prostate computer-aided diagnosis (CAD) based on random forest to detect cancer using a combination of spatial, intensity, and texture features extracted from three sequences, T2W, ADC, B2000 images, is proposed. The training considers instance-level weighting for equal treatment small large cancerous lesions as well backgrounds. Two other approaches, an AutoContext pipeline intended make better use sequence-specific patterns, were considered. One uses individual sequences while the image...
Prostate Cancer (PCa) is highly prevalent and the second most common cause of cancer-related deaths in men. Multiparametric MRI (mpMRI) robust detecting PCa. We developed a weakly supervised computer-aided detection (CAD) system that uses biopsy points to learn identify PCa on mpMRI. Our CAD system, which based deep convolutional neural network architecture, yielded an area under curve (AUC) 0.903±0.009 receiver operation characteristic (ROC) computed 10 different models fold...
Here we investigate the ability of low-intensity ultrasound (LIUS) applied to spinal cord modulate transmission motor signals.
Growing evidence suggests that piriform cortex resection during anterior temporal lobectomy is important for achieving good seizure outcome in mesial lobe epilepsy (mTLE). However, the relationship between and ablation MR-guided laser interstitial thermal therapy (MRgLITT) remains unclear.To determine whether of was associated with patients mTLE undergoing MRgLITT.We performed preablation postablation volumetric analyses hippocampus, amygdala, cortex, volumes who underwent MRgLITT at our...
Deep brain stimulation (DBS) is an effective surgical therapy for Parkinson's Disease (PD). However, limitations of the DBS systems have led to great interest in adaptive neuromodulation that can dynamically adjust parameters meet concurrent therapeutic demand. Constant, high-frequency motor cortex has not been remarkably efficacious, which greater focus on modulation subcortical targets. Understanding importance timing both cortical and generated developing more refined, parsimonious...
For women with access to healthcare and early detection, breast cancer deaths are caused primarily by metastasis rather than growth of the primary tumor. Metastasis has been difficult study because it happens deep in body, occurs over years, involves a small fraction cells from Furthermore, within-tumor heterogeneity relevant can also lead therapy failures is obscured studies bulk tissue. Here we exploit identify molecular mechanisms metastasis. We use "organoids", groups hundreds tumor...
INTRODUCTION: Laser Interstitial Thermal Therapy (LiTT) is increasingly becoming a first-line surgical therapy for mesial temporal lobe epilepsy (mTLE). While promising, its seizure outcomes have also been highly variable, presumably due to an incomplete understanding of mechanisms behind LiTT. Epilepsy network disorder, and therefore it crucial account both the effect on local destruction epileptogenic foci, as well global intervention limbic circuitry, elucidate circuit-level LiTT devise...
Patient safety and efficiency are top priorities in any surgical procedure. One effective way to achieve these objectives is automate the logistical routine tasks that occur operating suite. Inspired by smart assistant technology already widely used consumer sector, we engineered Smart Hospital Assistant (SHA), a smart, voice-controlled virtual handles natural speech recognition while executing non-surgical functions aid surgery. In simulated procedures, SHA reduced time, optimized staff...
OBJECTIVE Piriform cortex (PC) is one of the critical structures in epileptogenesis mesial temporal lobe epilepsy (mTLE), but its role poorly understood. The authors examined utility apparent diffusion coefficient (ADC; an MR-based marker tissue pathology) PC as a predictor seizure outcome patients with mTLE undergoing MR-guided laser interstitial thermal therapy (MRgLITT). METHODS A total 33 diagnosed who underwent MRgLITT at authors’ institution were included study. 6-month postoperative...
The use of intraoperative robotics and imaging for spine surgery has been shown to be safe, efficacious, beneficial patients, offering accurate placement instrumentation, decreased operative time blood loss, improved postoperative outcomes. Despite these proven benefits, it yet uniformly adopted. One the major barriers universal adoption is learning curve this complex technology, in conjunction with a lack formalized training. These same obstacles were faced introduction surgical technology...
OBJECTIVE Maximal safe ablation of target structures during magnetic resonance–guided laser interstitial thermal therapy (MRgLiTT) is critical to achieving good seizure outcome in patients with mesial temporal lobe epilepsy (mTLE). The authors sought determine whether intraoperative physiological variables are associated volume MRgLiTT. METHODS Patients mTLE who underwent MRgLiTT at our institution from 2014 2019 were retrospectively analyzed. Ablation was determined volumetric analysis...
Laser interstitial thermal therapy (LiTT) is a minimally invasive surgical procedure for intractable mesial temporal epilepsy (mTLE). LiTT safe and effective, but seizure outcomes are highly variable due to patient variability, suboptimal targeting, incomplete ablation of the epileptogenic zone. Apparent diffusion coefficient (ADC) magnetic resonance imaging (MRI) sequence that can identify potential foci in lobe improve outcomes. The objective this study was investigate whether tissue...
Cotton balls are a versatile and efficient tool commonly used in neurosurgical procedures to absorb fluids manipulate delicate tissues. However, the use of cotton is accompanied by risk accidental retention brain after surgery. Retained can lead dangerous immune responses potential complications, such as adhesions textilomas. In previous study, we showed that ultrasound be safely detect operating area due distinct acoustic properties compared with surrounding tissue. this enhance...
Ultrasound holds promise for use in spinal cord injury cases both diagnostic and therapeutic purposes. Focused ultrasound applications demand an added threshold of study to ensure the safety efficacy therapy. For optimal treatment outcomes, it is crucial understand whether relevant structures are being targeting with sufficient energy without damaging neighboring tissue vasculature. However, difficult predict expected displacement pressure profile wavefront due challenges visualizing...
Tsehay, Yohannes; Srivastava, Siddhartha BS; Khalafallah, Adham M MD; Yi, Paul; Jones, Craig; Mukherjee, Debraj MD Author Information
Abstract Objective MR-guided Laser Interstitial Thermal Therapy (LiTT) is a minimally invasive surgical procedure for intractable mesial temporal epilepsy (mTLE). LiTT safe and effective but seizure outcomes are highly variable due to patient variability, suboptimal targeting, incomplete ablation of epileptogenic zone. Apparent Diffusion Coefficient (ADC) an MRI sequence that can identify potential foci in the lobe improve outcome. The objective this study was investigate whether tissue...