A5054600742- Ultrasound and Hyperthermia Applications
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Soft Robotics and Applications
- Dielectric materials and actuators
- Photoacoustic and Ultrasonic Imaging
- Muscle activation and electromyography studies
- 3D Printing in Biomedical Research
- Artificial Intelligence in Healthcare and Education
- Microfluidic and Bio-sensing Technologies
- Thermoregulation and physiological responses
- Advanced Drug Delivery Systems
- Ultrasound Imaging and Elastography
- Wireless Body Area Networks
- Analytical Chemistry and Sensors
- Knee injuries and reconstruction techniques
- Gas Sensing Nanomaterials and Sensors
- Tendon Structure and Treatment
- Cardiac and Coronary Surgery Techniques
- Surgical Simulation and Training
- Spinal Cord Injury Research
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neural Engineering
- Non-Invasive Vital Sign Monitoring
- Graphene and Nanomaterials Applications
Eli Lilly (United States)
2023-2024
University of Connecticut
2016-2022
Johns Hopkins University
2021-2022
Johns Hopkins Medicine
2022
Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches using mechanical stimulation tissue regeneration. Pressure sensors are often required to be implanted directly integrated with native soft biological systems. Therefore, devices should flexible at same time biodegradable avoid invasive removal surgery that can damage interfaced tissues. Despite recent...
Significance This paper describes a powerful biodegradable and biocompatible piezoelectric nanofiber platform for significant medical implant applications, including highly sensitive, wireless, force sensor the monitoring of physiological pressures, ultrasonic transducer delivery drugs across blood–brain barrier. Built upon materials commonly utilized in implants, devices can self-degrade, causing no harm to body, avoid any invasive removal surgeries.
More than 32.5 million American adults suffer from osteoarthritis, and current treatments including pain medicines anti-inflammatory drugs only alleviate symptoms but do not cure the disease. Here, we have demonstrated that a biodegradable piezoelectric poly(L-lactic acid) (PLLA) nanofiber scaffold under applied force or joint load could act as battery-less electrical stimulator to promote chondrogenesis cartilage regeneration. The PLLA generated controllable charge, which promoted...
Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that hydrogel with...
Abstract The emergence of the SARS‐CoV‐2 pandemic and airborne particulate matter (PM) pollution has led to remarkably high demand for face masks. However, conventional respirators are intended single use made from nondegradable materials, causing serious concern a plastic‐waste environmental crisis. Furthermore, these facemasks weakened in humid conditions difficult decontaminate. Herein, reusable, self‐sustaining, highly effective, humidity‐resistant air filtration membrane with excellent...
Abstract Objective Monitoring microcirculation and visualizing microvasculature are critical for providing diagnosis to medical professionals guiding clinical interventions. Ultrasound provides a medium monitoring visualization; however, there challenges due the complex microscale geometry of vasculature difficulties associated with quantifying perfusion. Here, we studied established state‐of‐the‐art ultrasonic modalities (using six probes) compare their detection slow flow in small...
Patient safety and efficiency are top priorities in any surgical procedure. One effective way to achieve these objectives is automate the logistical routine tasks that occur operating suite. Inspired by smart assistant technology already widely used consumer sector, we engineered Smart Hospital Assistant (SHA), a smart, voice-controlled virtual handles natural speech recognition while executing non-surgical functions aid surgery. In simulated procedures, SHA reduced time, optimized staff...
Abstract Background The spinal intrathecal space, characterized by a complex three‐dimensional (3D) fluid‐filled geometry with varying levels of anatomic intricacy, plays pivotal role in drug administration strategies targeting the central nervous system (CNS). Lumbar injections into this space represent clinically used approach for delivering therapeutics directly to brain, bypassing critical barriers such as blood‐brain and blood‐cerebrospinal fluid barriers. A nuanced understanding CSF...
Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches using mechanical stimulation tissue regeneration. Pressure sensors are often required to be implanted directly integrated with native soft biological systems. Therefore, devices should flexible at same time, biodegradable, avoid invasive removal surgery that can damage directly-interfaced tissues. Despite...
Abstract Focused ultrasound (FUS) is becoming widely researched for medical therapies due to its high penetration depth, spatial resolution, and affordability. Applications of FUS range from intensity focused (HIFU) the ablation cancerous tumors low (LIFU) treatment neurological conditions like essential tremors. A key step in developing these treatments their corresponding devices characterizing emitted proposed transducer. However, a bottleneck exists at this verification validation stage;...
Objects accidentally left behind in the brain following neurosurgical procedures may lead to life-threatening health complications and invasive reoperation. One of most commonly retained surgical items is cotton ball, which absorbs blood clear surgeon's field view yet process becomes visually indistinguishable from parenchyma. However, using ultrasound imaging, different acoustic properties tissue result two discernible materials. In this study, we created a fully automated foreign body...
Abstract Many surgeons are faced with inoperable or only partially operable brain lesions, such as tumors. Even when surgery is feasible, patient outcomes greatly affected by blood loss infection. This has led many physicians toward non- minimally-invasive surgery, which demands specialized toolkits. Focused ultrasound great potential for assisting in procedures due to its ability focus a few centimeters away from the surface of transducer. In prior study, we developed focused prototype that...
Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches using mechanical stimulation tissue regeneration. Pressure sensors are often required to be implanted directly integrated with native soft biological systems. Therefore, devices should flexible at same time, biodegradable, avoid invasive removal surgery that can damage directly-interfaced tissues. Despite...
Abstract Universalized point-of-care medicine demands long-term, automated, and ubiquitous solutions to monitoring patients. Ultrasound imaging can be found in nearly all fields of healthcare. Therefore, developing a platform for continuous ultrasound acquisition could transform the arena. However, long-term using requires both simplification large quantities data hands-free, flexible device. Here, we reduce data-heavy spectral Doppler by tracking local vascular flow vitro vivo as single,...
Cotton balls are a versatile and efficient tool commonly used in neurosurgical procedures to absorb fluids manipulate delicate tissues. However, the use of cotton is accompanied by risk accidental retention brain after surgery. Retained can lead dangerous immune responses potential complications, such as adhesions textilomas. In previous study, we showed that ultrasound be safely detect operating area due distinct acoustic properties compared with surrounding tissue. this enhance...
Abstract Standard diagnostic ultrasound imaging procedures heavily rely on a sonographer for image acquisition. Given the probe is manually manipulated by sonographer, there potential noise artifacts like blurry acquired images caused involuntary hand movements. Certain surgical can also cause patients to exhibit “jumping” movements while operating table leading further deterioration in quality. In this study, we attempt mitigate these problems fabricating 3D-printed holder. Due lightweight...
Abstract Transcranial ultrasound stimulation is a neuromodulation technique that capable of exciting or suppressing the neural network. The neuromodulatory effect on cerebral hemodynamics has been monitored using optical methods like laser speckle contrast imaging in animal studies. However, bulky size and stationary nature system constrains application research requires to be irregular body positions awake. Here, we present design miniature imager monitor blood flow changes during...
OBJECTIVES/GOALS: The first aim was to construct a controlled and high resolution FUS water tank characterization system with 1 micron step-sizes. second create two unique standardized protocols for mapping the generated acoustic field from transducers; protocol one maps full 3D while rapidly detects changes original plot. METHODS/STUDY POPULATION: To accomplish one, focused ultrasound platform constructed conditioning unit degassing temperature control, three-axis stage step-size...
Abstract Glioblastoma Multiforme (GBM) is a malignant brain cancer with low overall survival. Therefore, researchers are looking to augment its current therapeutic regimen, which includes surgical tumor resection, chemotherapy and radiation. A promising treatment modality, focused ultrasound, has been used as non-invasive for GBM through multiple approaches such thermal ablation, immunomodulation, blood barrier disruption. In order develop these treatments clinical trials, testing in animal...
Abstract Focused ultrasound (FUS) is an emerging technique with the potential to revolutionize traditional treatment methods in fields of oncology and neurosurgery. Recently, FUS treatments have shown for altering neural activity spinal cord, intent alleviate pain. Preliminary animal studies using demonstrated need transducer accessories that can simplify implementation clinic. The coupling cone was supplied designed larger target tissues. Thus, surgeons expressed a desire adapt design be...