A5087932611- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Neurological disorders and treatments
- Epilepsy research and treatment
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Advanced MRI Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Pain Management and Treatment
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
Johns Hopkins Hospital
2021-2023
Johns Hopkins University
2011-2022
Johns Hopkins Medicine
2015-2022
Multiple Sclerosis Society
2021
University College London
2021
Janssen (United States)
2020
Columbia University
2008-2018
The University of Texas at Austin
2018
University of Hawaiʻi at Mānoa
2018
La Sierra University
2018
Background and Purpose— The purpose of this study was to assess the frequency, severity, predictors neurological deficits after adjuvant embolization for cerebral arteriovenous malformations. Methods— From 1997 2006, 202 275 patients with malformation received before microsurgery (n=176) or radiosurgery (n=26). Patients were examined endovascular at clinical follow-up (mean, 43.4±34.6 months). Outcome classified according modified Rankin Scale. New defined as minimal (no change in overall...
Intraventricular hemorrhage (IVH) associated with intracerebral (ICH) is an independent predictor of poor outcome. Clinical methods for evaluating IVH, however, are not well established. This study sought to determine the best IVH grading scale by predictive accuracies Graeb, and LeRoux scores in cohort ICH patients IVH. Subacute dynamics as impact external ventricular drain (EVD) placement on outcome were also investigated.A consecutive 142 primary was admitted Columbia University Medical...
Brain-computer interfaces (BCIs) are devices that acquire and transform neural signals into actions intended by the user. These have been a rapidly developing area of research over past 2 decades, military has made significant contributions to these efforts. Presently, BCIs can provide humans with rudimentary control computer systems robotic devices. Continued advances in BCI technology especially pertinent setting, given potential for therapeutic applications restore function after combat...
Phase-amplitude coupling (PAC) in which the amplitude of a faster field potential oscillation is coupled to phase slower rhythm, one most well-studied interactions between oscillations at different frequency bands. In healthy brain, PAC accompanies cognitive functions such as learning and memory, changes have been associated with neurological diseases including Parkinson's disease (PD), schizophrenia, obsessive-compulsive disorder, Alzheimer's disease, epilepsy./Hypothesis: PD, normalization...
Background and Purpose— Hyperglycemia after spontaneous intracerebral hemorrhage (ICH) is associated with poor outcome, but the pathophysiology of ICH-induced glucose dysregulation remains unclear. We sought to identify clinical radiographic parameters ICH that are admission hyperglycemia. Methods— Patients admitted Columbia University Medical Center Neurological Intensive Care Unit between January 2009 September 2010 were prospectively enrolled in Outcomes Project. Clinical, radiographic,...
Biological drug products are formulated with excipients to maintain stability over the shelf life of product. Surfactants added product stabilize air–water interfaces known induce protein aggregation. Early formulation development is focused on maintaining conformation and colloidal course but rarely considers through dose preparation administration. Specifically, intravenous (IV) bag exposes therapeutic a different solution environment concurrently diluting stabilizing that had been...
Traumatic spinal cord injury (SCI) is a common and devastating condition. In the absence of effective validated therapies, there an urgent need for novel methods to achieve stabilization, regeneration, functional restoration in SCI patients. Ultrasound versatile platform technology that can provide foundation viable diagnostic therapeutic interventions SCI. particular, real-time perfusion inflammatory biomarker monitoring, focal pharmaceutical delivery, neuromodulation are capabilities be...
Increased expression angiogenic factors, such as matrix metalloproteinases (MMPs), are associated with the formation of cerebral arteriovenous malformations (AVMs). The objective this study was to determine plasma levels MMP-9 patients AVMs.Blood samples were drawn from 15 AVMs before treatment, 24 hours postembolization, postresection, and 30 days postresection. Blood also obtained healthy controls. Plasma concentrations measured via enzyme-linked immunosorbent assay.The mean level in AVM...
Growing evidence suggests that piriform cortex resection during anterior temporal lobectomy is important for achieving good seizure outcome in mesial lobe epilepsy (mTLE). However, the relationship between and ablation MR-guided laser interstitial thermal therapy (MRgLITT) remains unclear.To determine whether of was associated with patients mTLE undergoing MRgLITT.We performed preablation postablation volumetric analyses hippocampus, amygdala, cortex, volumes who underwent MRgLITT at our...
In this report, the evidence, mechanisms, and rationale for practice of artificial cranial deformation (ACD) in ancient Peru during Akhenaten's reign 18th dynasty Egypt (1375-1358 BCE) are reviewed. The authors argue that insufficient attention has been given to sociopolitical implications both regions. While evidence from is widespread complex, there comparatively fewer examples deformed crania period rule. Nevertheless, own deformity, skull so-called "Younger Lady" mummy, Tutankhamen's all...
<h3>Background</h3> Up to 28% of patients undergoing carotid endarterectomy (CEA) are estimated experience neurocognitive dysfunction following surgery. The complement cascade plays a central role in ischaemia-reperfusion injury. authors investigated the effect common polymorphisms component 3 (C3F) and factor H (CFH Y402H) genes on incidence post-CEA. <h3>Methods</h3> This study examined nested cohort prospectively recruited receiving elective CEA, who were genotyped for C3F or Y402H...