A5048325290- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Thermoregulation and physiological responses
- Venous Thromboembolism Diagnosis and Management
- Photovoltaic System Optimization Techniques
- Prosthetics and Rehabilitation Robotics
- Pain Management and Treatment
- Intravenous Infusion Technology and Safety
- Advanced DC-DC Converters
- Diagnosis and Treatment of Venous Diseases
- Wireless Body Area Networks
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Liver Disease Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Dental Radiography and Imaging
- AI in cancer detection
- solar cell performance optimization
- Barrier Structure and Function Studies
- Effects of Radiation Exposure
- Soft Robotics and Applications
- Advanced MRI Techniques and Applications
- Artificial Intelligence in Healthcare and Education
University of Michigan
2022-2025
Johns Hopkins University
2021-2023
Johns Hopkins Medicine
2023
SRM Institute of Science and Technology
2018
This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in murine brain. We have termed it All-in-One FUS for brain studies, which is first its kind. The 1.5 MHz transducer was fabricated driven using custom electronic driver to produce 3-cycle pulses with focal peak-negative...
Abstract Purpose To develop methods for dynamic cavitation monitoring of a non‐invasive ultrasound mechanical ablation technology (histotripsy) in the brain and test its feasibility treatment ex‐vivo human MRI scanner. Methods A Gradient Echo (GRE) pulse sequence was modified with bipolar gradient to perform MR‐Cavitation Dynamics Encoded (MR‐CaDE) imaging. Cavitation generated by histotripsy sonication monitored using MR‐CaDE imaging bovine tissues on Bipolar gradients b‐value smaller were...
Abstract Objective Monitoring microcirculation and visualizing microvasculature are critical for providing diagnosis to medical professionals guiding clinical interventions. Ultrasound provides a medium monitoring visualization; however, there challenges due the complex microscale geometry of vasculature difficulties associated with quantifying perfusion. Here, we studied established state‐of‐the‐art ultrasonic modalities (using six probes) compare their detection slow flow in small...
Thromboembolism in blood vessels poses a serious risk of stroke, heart attack, and even sudden death if not properly managed. Sonothrombolysis combined with ultrasound contrast agents has emerged as promising approach for the effective treatment thromboembolism. Recent reports have highlighted potential intravascular sonothrombolysis safe modality deep vein thrombosis (DVT). However, its efficiency been validated through vivo testing retracted clots. This study aimed to develop miniaturized...
Histotripsy is a non-invasive, non-thermal focused ultrasound ablation method that mechanically breaks down the target tissue into acellular debris and has shown promising results for brain surgery. Quantifying histotripsy treatment dosage required to avoid over/under-treatment of region. In this work, we assess whether T1, T2 ADC maps can be utilized quantify effect generated by varying post-treatment using an ex-vivo bovine brain. We show only map able visualize ablation. Increasing in...
Motivation: Transcranial histotripsy requires pre-therapy targeting to ensure treatment at the intended region of interest. MR-ARFI and MR-Thermometry are used for HIFU treatments, but not tested transcranial treatments since they use different ultrasound parameters. Goal(s): We evaluate accuracy MR-thermometry in ex-vivo tissues. Approach: Low intensity were done prior on bovine brain The lesion location was compared with peak temperature/displacement quantify error. Results: Both can...
Abstract Many surgeons are faced with inoperable or only partially operable brain lesions, such as tumors. Even when surgery is feasible, patient outcomes greatly affected by blood loss infection. This has led many physicians toward non- minimally-invasive surgery, which demands specialized toolkits. Focused ultrasound great potential for assisting in procedures due to its ability focus a few centimeters away from the surface of transducer. In prior study, we developed focused prototype that...
Cotton balls are a versatile and efficient tool commonly used in neurosurgical procedures to absorb fluids manipulate delicate tissues. However, the use of cotton is accompanied by risk accidental retention brain after surgery. Retained can lead dangerous immune responses potential complications, such as adhesions textilomas. In previous study, we showed that ultrasound be safely detect operating area due distinct acoustic properties compared with surrounding tissue. this enhance...
Abstract Standard diagnostic ultrasound imaging procedures heavily rely on a sonographer for image acquisition. Given the probe is manually manipulated by sonographer, there potential noise artifacts like blurry acquired images caused involuntary hand movements. Certain surgical can also cause patients to exhibit “jumping” movements while operating table leading further deterioration in quality. In this study, we attempt mitigate these problems fabricating 3D-printed holder. Due lightweight...
Abstract Transcranial ultrasound stimulation is a neuromodulation technique that capable of exciting or suppressing the neural network. The neuromodulatory effect on cerebral hemodynamics has been monitored using optical methods like laser speckle contrast imaging in animal studies. However, bulky size and stationary nature system constrains application research requires to be irregular body positions awake. Here, we present design miniature imager monitor blood flow changes during...
Intraoperative blood salvage (cell salvage) has been increasingly used in the past few decades; it gained attention when Jehovah's victims 1945 introduced a doctrine not accepting allogenic transfusions.This created need for autologous transfusion, which momentum decades.However, transfusion cannot be carried out an unsterilized environment.A device proposed this paper, can purify upto 2 liters of lost by individual, and transfuse back into body.The unique feature is that works...
Shape-Memory Alloys (SMAs) has been gaining impetus in everyday applications, especially the field of bioengineering.They are used implants, prosthetics and minimally invasive procedures to name a few.This paper talks about new mechanism that can be help humans who victims partial paralysis walk.The involved uses combination SMAs piezo-electric sensors assist these patients have natural gait.This involves wearing knee-cap, which consists boot piezoelectric sensors.This is different from...
Purpose The aim of this research study is to mitigate shading impact on solar photovoltaic array. Photovoltaic (PV) array when getting shaded not only results in appreciable power loss but also exhibits multiple peaks. Due these peaks, the maximum point tracking (MPPT) controllers’ performance will be affected, as most times it ends up local peak and global peak. Design/methodology/approach PV panels an even partially would result huge loss. pattern plays a crucial role, renders cascaded...