A5023199835- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Spine and Intervertebral Disc Pathology
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Trauma Management and Diagnosis
- Metabolism, Diabetes, and Cancer
- Innovations in Medical Education
- Medical Imaging and Analysis
- Brain Metastases and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Cardiac Arrest and Resuscitation
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Pelvic and Acetabular Injuries
- Influenza Virus Research Studies
Johns Hopkins Medicine
2022-2024
Johns Hopkins University
2021-2024
INTRODUCTION: The local delivery of chemotherapeutic agents to glioblastoma using implantable biodegradable polymers emerged as an appealing mechanism overcome the BBB. Additionally, use synergistic drug combinations is a plausible method prevent treatment resistance. METHODS: We prepared nanogel pellet with PLGA-PEG-PLGA triblock backbone and loaded it combination TMZ PTX. characterized thermosensitive transition this formulation studied its release kinetics in artificial cerebrospinal...
Here we investigate the ability of low-intensity ultrasound (LIUS) applied to spinal cord modulate transmission motor signals.
Synthetic computed tomography (sCT) can be created from magnetic resonance imaging (MRI) utilizing newer software. sCT is yet to explored as a possible alternative routine CT (rCT). In this study, rCT scans and MRI-derived were obtained on cadaver. Morphometric analysis was performed comparing the 2 scans. The ExcelsiusGPS robot used place lumbosacral screws with both images.In total, 14 placed. All grade A Gertzbein-Robbins scale. mean surface distance difference between reconstructed...
Serpins are serine proteinase inhibitors, with several serpins being overexpressed in cancer cells. Thus, we aim to analyze the single-nucleotide polymorphism (SNP) of Serpinb11 and its association GBM survival. A cohort 63 patients recruited from King Abdullah University Hospital Jordan underwent analysis overall survival (OS) assessments. The Cancer Genome Atlas (GBM) was useful for validation. We constructed a risk score using principal component following Serpin genes: Serpinb3,...
Significant advancements in the treatment of spinal cord injury (SCI) were developed setting military conflicts, partly due to large numbers injuries sustained by service members. No effective SCI options existed into early 20th century, and soldiers who these usually considered untreatable. Extensive progress was made during after World War II, as physical therapy increasingly encouraged for patients with SCI, multidisciplinary teams oversaw care, pathophysiology better understood,...
Glioblastoma (GBM) represents a profoundly aggressive and heterogeneous brain neoplasm linked to bleak prognosis. Hypoxia, common feature in GBM, has been tumor progression therapy resistance. In this study, we aimed identify hypoxia-related differentially expressed genes (DEGs) construct prognostic signature for GBM patients using multi-omics analysis. Patient cohorts were collected from publicly available databases, including the Gene Expression Omnibus (GEO), Chinese Glioma Genome Atlas...
The epidemic is an imminent danger that all humans fear, as it does not differentiate between anyone, whether small or old, rich poor. It characterized by its ability and super speed to conquer the world primary goal target eradicate their lives. In this article, authors decided provide a brief historical overview of Spanish flu pandemic, where initiated how influenced people earth review set images about events occurred in United States America 1918. All facts article are collected from...
Retrospective cohort study.The aim was to investigate the accuracy of pedicle screw placement by freehand technique and compare revision surgery rates among three different imaging verification pathways.Studies comparing modalities in are limited.A single-institution retrospective chart review identified adult patients who underwent thoracic, lumbar or sacral levels. Patients were stratified into cohorts based on intraoperative modality used assess position: X-rays (cohort 1); O-arm 2);...
Glioblastoma multiforme is the most frequently diagnosed primary malignant brain tumor. Despite multimodal therapy with surgical resection, radiation therapy, and chemotherapy, recurrence of tumor almost always guaranteed due to infiltrative nature disease. Moreover, blood barrier imparts an additional layer complexity by impeding delivery therapeutic agents tumor, hence limiting efficacy systemically delivered drugs. Hence, overcome this obstacle avoid treatment resistance, local...
Abstract Glioblastoma Multiforme (GBM) is a malignant brain cancer with low overall survival. Therefore, researchers are looking to augment its current therapeutic regimen, which includes surgical tumor resection, chemotherapy and radiation. A promising treatment modality, focused ultrasound, has been used as non-invasive for GBM through multiple approaches such thermal ablation, immunomodulation, blood barrier disruption. In order develop these treatments clinical trials, testing in animal...