A5074473602- Glioma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Microscopic Colitis
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Diverticular Disease and Complications
- Nanoparticle-Based Drug Delivery
- Phosphodiesterase function and regulation
- Hedgehog Signaling Pathway Studies
- Advanced biosensing and bioanalysis techniques
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Extracellular vesicles in disease
- Vascular anomalies and interventions
- Peripheral Artery Disease Management
- Cancer Mechanisms and Therapy
- Spine and Intervertebral Disc Pathology
- Gastrointestinal motility and disorders
- Ultrasound and Hyperthermia Applications
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2023-2025
American University of Beirut
2020-2023
American University of Beirut Medical Center
2022-2023
We introduce a two-pronged strategy comprising focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening and long-circulating biodegradable nanoparticles (NPs) for systemic delivery of nucleic acids to the brain. Biodegradable poly(β-amino ester) polymer-based NPs were engineered stably package various types acid payloads enable prolonged circulation while retaining excellent serum stability. FUS was applied predetermined coordinate within brain transiently open BBB, thereby...
INTRODUCTION: Glioblastoma (GBM) is an aggressive brain cancer that evades immune detection by altering the microenvironment. Nanoparticle-mediated gene therapy offers a potentially safe targeted strategy. METHODS: PBAE nanoparticles were synthesized and characterized using dynamic light scattering. In vitro, CT2A mouse glioblastoma cells transfected with containing GFP plasmid. Cell viability transfection efficiency assessed MTS assay flow cytometry. ELISA was used to measure IFNG...
INTRODUCTION: The local delivery of chemotherapeutic agents to glioblastoma using implantable biodegradable polymers emerged as an appealing mechanism overcome the BBB. Additionally, use synergistic drug combinations is a plausible method prevent treatment resistance. METHODS: We prepared nanogel pellet with PLGA-PEG-PLGA triblock backbone and loaded it combination TMZ PTX. characterized thermosensitive transition this formulation studied its release kinetics in artificial cerebrospinal...
e14042 Background: Standard of care for high-grade brain tumors involves surgical resection, followed by radiotherapy, leading to long recovery times. Nanoparticle (NP) gene therapy may provide a less invasive and targeted immune response eliminate tumors. Antigen-presenting cells (APCs) present T with antigens alongside costimulatory proteins (signal 2) cytokines 3), activating naive cells. Plasmids encoding Signal 2 (4-1BBL) 3 (IL-12) can be delivered via poly(beta-amino ester) (PBAE)...
Medulloblastoma is the most frequently encountered malignant brain tumor in pediatric population. The standard of care currently consists surgical resection, craniospinal irradiation, and multi-agent chemotherapy. However, despite this combination multiple aggressive modalities, recurrence disease remains a substantial concern, treatment resistance rising issue. development results from interplay myriad anatomical properties, cellular processes, molecular pathways, genetic epigenetic...
Glioblastoma multiforme is the most frequently diagnosed primary malignant brain tumor. Despite multimodal therapy with surgical resection, radiation therapy, and chemotherapy, recurrence of tumor almost always guaranteed due to infiltrative nature disease. Moreover, blood barrier imparts an additional layer complexity by impeding delivery therapeutic agents tumor, hence limiting efficacy systemically delivered drugs. Hence, overcome this obstacle avoid treatment resistance, local...
Abstract INTRODUCTION The development and course of inflammatory bowel disease (IBD) appears to be influenced by environmental factors. Particularly, smoking has been shown assume a harmful role in Crohn’s (CD) protective ulcerative colitis (UC). This study aims examine the effect on need for surgery patients with moderate severe receiving biologic therapy. METHODS Retrospective adult CD at University Medical Center over 20-year period. RESULTS A total 251 were included (mean age 36.0 ±...
Abstract Background To examine the effect of smoking on need for surgery in patients with moderate to severe Crohn’s disease (CD) receiving biologic therapy. Methods Retrospective study adult CD at a University Medical Center over 20-year period. Results A total 251 were included (mean age 35.9 ± 15.0; 70.1% males; current, former, and non-smokers: 44.2%,11.6%, 43.8%, respectively). Mean duration biologics was 5.0 3.1 years (>2/3 received anti-TNFs, followed by ustekinumab 25.9%)...
Venous aneurysmal dilatation is a rare pathology that has been reported few times in the literature. Compared to their arterial counterparts, venous aneurysms are much less prevalent and studied, they lack well-delineated guidelines regarding diagnosis management. Most of clinical practice on topic dependent scarce evidence from case reports, series, systematic reviews.1-3 usually classified according location affected vein into 4 main categories, which head neck region, thoracic cavity,...
Introduction: The development and course of inflammatory bowel disease appear to be influenced by environmental factors. Particularly, smoking has been shown assume a harmful role in Crohn’s (CD) protective ulcerative colitis. This study aims examine the effect on need for surgery patients with moderate severe CD receiving biologic therapy. Methods: was retrospective adult at University Medical Center over 20-year period. Results: A total 251 were included (mean age 36.0 ± 15.0; 70.1% males;...
A first seen and extremely unusual case of a non-jugular venous malformation underlying lipoma.