A5054610109- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Spinal Cord Injury Research
- Ultrasound Imaging and Elastography
- Diabetes and associated disorders
- Muscle activation and electromyography studies
- Polymer Surface Interaction Studies
- Immune Cell Function and Interaction
- Automotive and Human Injury Biomechanics
- Liver physiology and pathology
- Cardiac Arrest and Resuscitation
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Ultrasound and Hyperthermia Applications
Johns Hopkins University
2021-2025
Johns Hopkins Medicine
2021-2024
Biomedical devices comprise a major component of modern medicine, however immune-mediated fibrosis and rejection can limit their function over time. Here, we describe humanized mouse model that recapitulates following biomaterial implantation. Cellular cytokine responses to multiple biomaterials were evaluated across different implant sites. Human innate immune macrophages verified as essential in this capable cross-talk with fibroblasts for collagen matrix deposition. Cytokine receptor...
Replicating spinal cord injury (SCI) in large animals is necessary for evaluating therapeutics potential human translation, yet there currently no commercial, standardized device inducing SCI. We present the fabrication and testing of a custom impactor producing repeatable contusion SCI porcine models. first designed built device. Mechanical modeling was subsequently utilized to calibrate our benchtop setup. Benchtop verification performed measure impact force post calibration. then used...
Here we investigate the ability of low-intensity ultrasound (LIUS) applied to spinal cord modulate transmission motor signals.
Type 1 diabetes (T1D) is a life-threatening condition for which islet transplantation offers way to extend longevity and vastly improve quality of life, but the degree duration success can vary greatly due patient's protective immunity against foreign material. The field in need cellular engineering modalities promote localized, tolerogenic environment protect transplanted tissue. Artificial antigen-presenting cells (aAPCs) be designed exogenously mimic immune cells, such as dendritic...
Abstract Biomedical devices such as islet‐encapsulating systems are used for treatment of type 1 diabetes (T1D). Despite recent strides in preventing biomaterial fibrosis, challenges remain scaffolds due to limitations on cells contained within. The study demonstrates that proliferation and function insulinoma (INS‐1) well pancreatic rat islets may be improved alginate hydrogels with optimized gel%, crosslinking, stiffness. Quantitative polymerase chain reaction (qPCR)‐based graft...
INTRODUCTION: Stem cells promote spinal cord injury (SCI) recovery by secreting paracrine factors that orchestrate endogenous healing mechanisms. However, effects in clinical trials are modest and there no approved stem cell therapies to treat SCI. Major barriers include washout, immune attack, oncogenic potential. METHODS: ITBs were implanted three pigs. One pig received a cell-loaded ITB without (Cells), another with (Cells + SCI), sham (SCI). SCIs induced weight drop at T5. cranial the...