A5014736137- Immune Cell Function and Interaction
- Immune Response and Inflammation
- CAR-T cell therapy research
- interferon and immune responses
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Streptococcal Infections and Treatments
- CRISPR and Genetic Engineering
- Pesticide Residue Analysis and Safety
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Respiratory viral infections research
- Immune cells in cancer
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Research and Splicing
- Antibiotics Pharmacokinetics and Efficacy
- Natural product bioactivities and synthesis
- Ovarian function and disorders
- T-cell and B-cell Immunology
- Essential Oils and Antimicrobial Activity
- Gallbladder and Bile Duct Disorders
- Chromatography in Natural Products
Xuzhou Medical College
2025
Nanjing Drum Tower Hospital
2025
Baoji City Central Hospital
2025
Hebei Medical University
2020-2024
Jishou University
2024
Chinese PLA General Hospital
2024
University of California, Los Angeles
2022-2024
Dalian Medical University
2020-2024
Second Affiliated Hospital of Dalian Medical University
2020-2024
University of Chinese Academy of Sciences
2021-2024
Abstract Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be avoided by using ‘off-the-shelf’ products, such as allogeneic CAR natural killer ( Allo CAR-NKT) cells. Previously, we reported a system for differentiating human hematopoietic stem progenitor into CAR-NKT cells, but the use of three-dimensional culture xenogeneic feeders precluded its clinical application. Here describe clinically guided...
Abstract The ULK complex initiates the autophagosome formation, and has recently been implicated in selective autophagy by interacting with receptors through its FIP200 subunit. However, structural mechanism underlying interactions of relevant regulatory remain elusive. Here, we discover that Claw domain CCPG1 Optineurin can be regulated phosphorylation their respective FIP200-binding regions. We determine crystal structures phosphorylated Optineurin, elucidate detailed molecular governing...
Uncontrolled inflammation occurred in sepsis results multiple organ injuries and shock, which contributes to the death of patients with sepsis. However, regulatory mechanisms that restrict excessive are still elusive. Here, we identified an Ig-like receptor called signaling lymphocyte activation molecular family 7 (SLAMF7) as a key suppressor during We found expression SLAMF7 on monocytes/macrophages was significantly elevated septic mice. attenuated TLR-dependent MAPK NF-κB macrophages by...
The controlled injection of nanoscopic objects into living cells with light offers promising prospects for the development novel molecular delivery strategies or intracellular biosensor applications. Here, we show that single gold nanoparticles from solution can be patterned on surface a continuous wave laser beam. In second step, demonstrate how same particles then injected through combination plasmonic heating and optical force. We find short exposure times are sufficient to perforate cell...
Abstract Macrophages play a crucial role in host innate anti-mycobacterial defense, which is tightly regulated by multiple factors, including microRNAs. Our previous study showed that panel of microRNAs was markedly up-regulated macrophages upon mycobacterial infection. Here, we investigated the biological function miR-146a during expression induced both vitro and vivo after Mycobacterium bovis BCG The inducible could suppress nitric oxide (NO) synthase (iNOS) NO generation, thus promoting...
Devising strategies for the controlled injection of functional nanoparticles and reagents into living cells paves way novel applications in nanosurgery, sensing, drug delivery. Here, we demonstrate light-controlled guiding plasmonic Janus nanopens cells. The pens are made a gold nanoparticle attached to dielectric alumina shaft. Balancing optical thermophoretic forces an tweezer allows single be trapped positioned on surface While process involves strong heating side, temperature stays...
Macrophage phagocytosis contributes predominantly to processing central nervous system (CNS) debris and further facilitates neurological function restoration after CNS injury. The aims of this study were evaluate the effect bone marrow mesenchymal stem cells (BMSC)-derived exosomes (BMSC-Exos) on phagocytic capability macrophages clear myelin investigate underlying molecular mechanism during spinal cord injury (SCI) process. This work reveals that monocyte-derived (MDMs) infiltrating into...
Ultrasound (US) has been widely used in screening and differential diagnosis of gallbladder wall thickening (GWT). However, the sensitivity specificity for diagnosing wall-thickening type cancer are limited, leading to delayed treatment or overtreatment. We aim explore value high frame rate contrast enhanced ultrasound (H-CEUS) distinguishing (malignant) from GWT mimicking malignancy (benign).
Non-small cell lung cancer (NSCLC) accounts for about 85% of all cancers. Traditional chemotherapy this disease leads to serious side effects. Here we prepared an inhalable oridonin-loaded poly(lactic-
Abstract Context The high mobility group AT hook 2 (HMGA2) gene was previously identified in a genome-wide association study as candidate risk that might be related to polycystic ovary syndrome (PCOS). Whether HMGA2 contributes promoting granulosa cell (GC) proliferation PCOS remains unknown. Objective We sought determine whether is involved the ovarian dysfunction of and mechanism increased GC proliferation. Patients Cells mRNA expression analyzed GCs from 96 women with 58 healthy controls....
Abstract Allogeneic Vγ9Vδ2 (Vδ2) T cells have emerged as attractive candidates for developing cancer therapy due to their established safety in allogeneic contexts and inherent tumor-fighting capabilities. Nonetheless, the limited clinical success of Vδ2 cell-based treatments may be attributed donor variability, short-lived persistence, tumor immune evasion. To address these constraints, we engineer with enhanced attributes. By employing CD16 a selection biomarker, harness characterized by...
Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these in development gastric remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis, we identified enrichment specific microbial communities within tumors patients, possibly affecting microenvironment by immune modulation, metabolic processes, inflammatory responses. Based results vivo experiments found...
Bacterial pneumonia is a serious disease with high mortality if no appropriate and immediate therapy available. Andrographolide (AG) an anti-inflammatory agent extracted from traditional Chinese herb andrographis paniculata. Oral AG tablets pills are clinically applied for treatment of upper respiratory tract infections. However, the low solubility bioavailability lead to doses long-term therapy. Here we developed andrographolide-β-cyclodextrin inclusion complex (AG-β-CD) inhalation...
Penicillin remains one of the most frequently identified violative drug residues in food-producing animals. The predominant violations penicillin were found cull dairy cows. In United States, procaine G is approved to be used cows through intramuscular (IM) and intramammary (IMM) administrations. Physiologically based pharmacokinetic (PBPK) models are useful tools predict withdrawal intervals tissue drugs food animals ensure safety, especially for extralabel use due scarcity experimental...
Residue depletion of T-2 toxin in chickens after oral gavage at 2.0 mg/kg twice daily for 2 days was determined this study. A flow-limited physiologically based pharmacokinetic (PBPK) model developed lifetime exposure assessment chickens. The calibrated with data from the residue study and then validated independent data. local sensitivity analysis performed, 16 sensitive parameters were subjected to Monte Carlo analysis. population PBPK applied estimate intake values different countries on...