A5100440294- Additive Manufacturing and 3D Printing Technologies
- Pregnancy and preeclampsia studies
- Polymer composites and self-healing
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Advanced Polymer Synthesis and Characterization
- Additive Manufacturing Materials and Processes
- Industrial Vision Systems and Defect Detection
- Silicone and Siloxane Chemistry
- MicroRNA in disease regulation
- Immune cells in cancer
- Carbon dioxide utilization in catalysis
- Ferroptosis and cancer prognosis
- Manufacturing Process and Optimization
- Advanced Sensor and Energy Harvesting Materials
- Cancer, Hypoxia, and Metabolism
- Synthesis and properties of polymers
- Advanced machining processes and optimization
- Reproductive Biology and Fertility
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Photorefractive and Nonlinear Optics
- Surface Roughness and Optical Measurements
- Photopolymerization techniques and applications
- Nanoplatforms for cancer theranostics
Shandong University
2016-2025
Affiliated Hospital of Southwest Medical University
2025
Shandong Provincial Hospital
2013-2024
Shandong First Medical University
2018-2024
Jilin University
2024
State Key Laboratory of Supramolecular Structure and Materials
2024
Capital Medical University
2024
Peking University
2024
Beijing Jishuitan Hospital
2024
Academic Center for Dentistry Amsterdam
2023
Fused deposition modeling (FDM) has unique advantages in the rapid prototyping of thermoplastics which have been developed diverse fields. However, although great efforts made to optimize FDM process, mechanical properties printed parts are limited by weak interlamination bonding as well poor performance raw filaments used, such acrylonitrile butadiene styrene (ABS), polylactic acid (PLA). Adding fibers into thermoplastic matrix and preparing high-performance indicated enhance fabricated...
Abstract Autophagy, a lysosome‐involved degradation pathway, as self‐protective cellular process, always weakens the efficiency of tumor therapies. Herein, for first time, biodegradable copper (Cu) ions doped layered double hydroxide (Cu‐LDH) nanoparticles are reported cancer immunotherapy via lysosomal rupture‐mediated “Broken Window Effect”. Only injection Cu‐LDH single therapeutic agent achieves various organelles destruction after rupture, well abnormal aggregation Cu in cells...
A zirconium-based metal–organic framework (MOF) was successfully constructed via solvothermal assembly of a triphenylamine-based tricarboxylate ligand and Zr(IV) salt, the structure simulation which revealed that it possesses two-dimensional layered with relatively rare dodecnuclear Zr12 cluster as inorganic building unit. The inherent photo-responsive property derived from incorporated photochromic triphenylamine groups combined its high stability makes MOF an efficient heterogeneous...
Breaking immunosuppressive tumor microenvironment (TME) has unique effects on inhibiting growth and recurrence. Here, an endoplasmic reticulum (ER) targeted PdPtCu nanozyme (PNBCTER ) is prepared to boost immunotherapy. First, PNBCTER three kinds of enzyme activities, including catalase (CAT), glutathione oxidase (GSHOx), peroxidase (POD)-like which can reshape the TME. Second, kills cells by photodynamic therapy (PDT) photothermal (PTT). Third, guided TER , not only realizes combination...
Abstract This research presents a lattice structure topology optimization (LSTO) method that significantly expands the design space by creating novel candidate assesses an extremely large range of effective material properties. About details, is employed to lattices with extreme directional tensile or shear properties subject different volume fraction limits and optimized are categorized into groups according their dominating The developed combining elementary lattices, picking up one from...
Abstract Context The high mobility group AT hook 2 (HMGA2) gene was previously identified in a genome-wide association study as candidate risk that might be related to polycystic ovary syndrome (PCOS). Whether HMGA2 contributes promoting granulosa cell (GC) proliferation PCOS remains unknown. Objective We sought determine whether is involved the ovarian dysfunction of and mechanism increased GC proliferation. Patients Cells mRNA expression analyzed GCs from 96 women with 58 healthy controls....
Abstract Placenta accreta spectrum (PAS) is a high-risk obstetrical condition associated with significant morbidity and mortality. Current clinical screening modalities for PAS are not always conclusive. Here, we report nanostructure-embedded microchip that efficiently enriches both single clustered circulating trophoblasts (cTBs) from maternal blood detecting PAS. We discover uniquely high prevalence of cTB-clusters in subsequently optimize the device to preserve intactness these clusters....
The emergence of novel and efficient polymerization methodologies grounded in organic transformations has profoundly advanced the field polymer science materials engineering. In this work, enaminoester-based unsymmetrical Hantzsch reaction was established as a robust postpolymerization modification approach. This transformation exhibits several attractive features, including high efficiency, mild catalyst-free conditions, water sole byproduct, broad functional group tolerance, direct...
Osteoporosis and obesity are both major global public health problems. Observational studies have found that osteoporosis might be related to obesity. Mendelian randomization (MR) analysis could overcome the limitations of observational in assessing causal relationships. This study aims evaluate potential relationship between obesity-related indicators by using a two-sample MR identify mediators. A total 53 indicators, 3,282 plasma protein lists, 452 blood metabolite lists were downloaded...
Gestational diabetes mellitus (GDM) is a disease condition in which woman develops high blood sugar levels during pregnancy, might be induced by multiple factors. Among those relative factors, microRNA (miRNA) well-known to involved GDM development. In this study, we investigated the role of miRNA analyzing expression profiling placenta tissues from healthy or pregnancies. We found that miR-96 was most down-regulated samples. Furthermore, target gene prediction revealed p21-activated kinase...