A5054216535- Material Dynamics and Properties
- Theoretical and Computational Physics
- Surface Roughness and Optical Measurements
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Optical Polarization and Ellipsometry
- Phase Equilibria and Thermodynamics
- Optical measurement and interference techniques
- Metallic Glasses and Amorphous Alloys
- Force Microscopy Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Adsorption, diffusion, and thermodynamic properties of materials
- Supercapacitor Materials and Fabrication
- Fluid Dynamics and Thin Films
- Anodic Oxide Films and Nanostructures
- nanoparticles nucleation surface interactions
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Copper Interconnects and Reliability
- Maternal and fetal healthcare
- Hepatocellular Carcinoma Treatment and Prognosis
- Innovative Microfluidic and Catalytic Techniques Innovation
California NanoSystems Institute
2019-2023
University of California, Los Angeles
2012-2023
Los Angeles City College
2018
Harbin Engineering University
2013-2014
University of Waterloo
1989-2013
Chinese Academy of Sciences
2003
Shandong Normal University
1999-2002
Shandong University of Technology
2000
FPInnovations
1993
Bacterial cellulose (BC) is used as both template and precursor for the synthesis of nitrogen‐doped carbon networks through carbonization polyaniline (PANI) coated BC. The as‐obtained can act not only support obtaining high capacitance electrode materials such activated (AC) carbon/MnO 2 hybrid material, but also conductive to integrate active materials. As a result, as‐assembled AC//carbon‐MnO asymmetric supercapacitor exhibits considerably energy density 63 Wh kg −1 in 1.0 m Na SO 4...
Abstract We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier creates more opportunities curative therapeutic interventions. EVs are present in circulation at relatively stages disease, providing potential detection. develop an EV (i.e., Click Chips) synergistically integrating chemistry-mediated capture/release, multimarker antibody...
Molecular-dynamics simulations of 500 particles have been performed to study the icosahedral order and defects in supercooled liquid glass states metallic ${\mathrm{Mg}}_{3}$${\mathrm{Ca}}_{7}$. Not only are Frank-Kasper polyhedra Bernal ``hole'' detected, but also a variety defective icosahedra. Especially, number type icosahedron defined by eight 1551 bonds, two 1661 1441 bonds is much greater than any kind polyhedra. This strongly supports physical picture liquids glasses being...
We use nanohole relaxation to study the surface of films glassy isotactic poly (methyl methacrylate) (i-PMMA) films. These measurements allow us obtain time dependent function at a number different sample temperatures for first 2-3 nm free in system often used as model effect substrate on thin film dynamics. The is observed relax up 42 K below bulk Tg value, even systems where known be greater than value. are able determine range over which directly affects relaxation, and surprisingly large...
Tumor-derived extracellular vesicles (EVs) present in bodily fluids are emerging liquid biopsy markers for non-invasive cancer diagnosis and treatment monitoring. Because the majority of EVs circulation not tumor origin, it is critical to develop new platforms capable enriching tumor-derived from blood. Herein, we introduce a biostructure-inspired NanoVilli Chip, highly efficient reproducible immunoaffinity capture blood plasma samples. Anti-EpCAM-grafted silicon nanowire arrays were...
Abstract Cell mechanical phenotype or ‘mechanotype’ is emerging as a valuable label-free biomarker. For example, marked changes in the viscoelastic characteristics of cells occur during malignant transformation and cancer progression. Here we describe simple scalable technique to measure cell mechanotype: this parallel microfiltration assay enables multiple samples be simultaneously measured by driving suspensions through porous membranes. To validate method, compare filtration untransformed...
Abstract Placenta accreta spectrum (PAS) is a high-risk obstetrical condition associated with significant morbidity and mortality. Current clinical screening modalities for PAS are not always conclusive. Here, we report nanostructure-embedded microchip that efficiently enriches both single clustered circulating trophoblasts (cTBs) from maternal blood detecting PAS. We discover uniquely high prevalence of cTB-clusters in subsequently optimize the device to preserve intactness these clusters....
Optimizing outcomes in prostate cancer (PCa) requires precision characterization of disease status. This effort was directed at developing a PCa extracellular vesicle (EV) Digital Scoring Assay (DSA) for detecting metastasis and monitoring progression PCa. EV DSA is comprised an purification device (i.e., Click Chip) reverse-transcription droplet digital PCR that quantifies 11 PCa-relevant mRNA purified PCa-derived EVs. A Met score computed each plasma sample based on the expression 11-gene...
From molecular-dynamics simulations, it is demonstrated that the structure factor has a second-peak splitting feature not only for glass states but also supercooled-liquid in some metallic cases. This appears to be due primarily presence of icosahedronlike clusters these suggests laboratory or simulated generally distorted solid including significant amount icosahedra, each consisting 13 atoms. lends strong support one various existing structural models, namely, Briant model.
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTUsing Nanoparticle Embedding Probe Surface Rheology and Length Scale of Mobility in Glassy PolymersM. Ilton†, D. Qi†, J. A. Forrest*View Author Information Department Physics Astronomy Guelph-Waterloo Institute, University Waterloo, 200 Ave. W., Ontario, Canada N2L 3G1*Corresponding author. E-mail: [email protected]†These authors contributed equally this work.Cite this: Macromolecules 2009, 42, 18,...
Extracellular matrices of living tissues exhibit viscoelastic properties, yet how these properties regulate chromatin and the epigenome remains unclear. Here, we show that substrates induce changes in nuclear architecture epigenome, with more pronounced effects on softer surfaces. Fibroblasts display larger nuclei, lower compaction, differential expression distinct sets genes related to cytoskeleton function, compared those elastic Slow-relaxing reduce lamin A/C enhance remodeling. These...
Abstract Tumor‐derived extracellular vesicles (EVs) play essential roles in intercellular communication during tumor growth and metastatic evolution. Currently, little is known about the possible of tumor‐derived EVs sarcoma because lack specific surface markers makes it technically challenging to purify sarcoma‐derived EVs. In this study, a purification system developed for Ewing (ES)‐derived by coupling covalent chemistry‐mediated EV capture/release within nanostructure‐embedded microchip....
Cell deformability is a label-free biomarker of cell state in physiological and disease contexts ranging from stem differentiation to cancer progression. Harnessing as phenotype for screening applications requires method that can simultaneously measure the hundreds samples interface with existing high throughput facilities. Here we present scalable filtration device, which relies on pressure-driven deformation cells through series pillars are separated by micron-scale gaps timescale seconds:...
We have made a detailed characterization of the molecular weight dependence isothermal gold nanoparticle embedding into surface atactic polystyrene films. Polymers in range 3 × 103 < Mw 1.2 106 g mol−1 were used within temperature that encompassed bulk glass transition temperature, around which both and heterogeneous dynamics measured. The also allows for comparison to recent studies on surfaces – essentially covering entire possible polymer sizes. results show there is different...
Numerous studies in hepatocellular carcinoma (HCC) have proposed tissue‐based gene signatures for individualized prognostic assessments. Here, we develop a novel circulating tumor cell (CTC)–based transcriptomic profiling assay to translate messenger RNA (mRNA) into liquid biopsy setting noninvasive HCC prognostication. The HCC‐CTC mRNA scoring system combines the NanoVelcro CTC Assay enriching CTCs and NanoString nCounter platform quantifying Risk Score (RS) panel enriched CTCs. role of RS...
With the aid of molecular-dynamics technique, a calculation thermodynamic and structural properties crystallization supercooled metallic liquid is presented. The calculated results demonstrate number features this crystallization. It now appears that transition associated with first-order-like phase in Ehrenfest scheme.
It is demonstrated, both theoretically and numerically, that the Gibbs–Bogoliubov (GB) thermodynamic variational calculation, developed originally for equilibrium systems, can be applied to a metastable system provided structure of reference system, used in this has same main features as under consideration. Following this, GB employing hard-sphere quantitatively determine metallic glass transition. Good agreement with observation obtained.
The morphology of random screens with different surface roughness is studied atomic force microscope and it found that their height distributions have very obvious fractal characteristics in short range regions.For larger smaller roughness,the fractals exist the forms fluctuations small grains without characteristic size respectively.The self-affine model introduced to quantitative descriptions randomscreens.The light scattering measurements show that:(1)the scattered intensity off-axis...
Transcriptomic profiling of tumor tissues introduces a large database, which has led to improvements in the ability cancer diagnosis, treatment, and prevention. However, performing transcriptomic clinical setting is very challenging since procurement inherently limited by invasive sampling procedures. Here, we demonstrated feasibility purifying hepatocellular carcinoma (HCC) circulating cells (CTCs) from patient samples with improved molecular integrity using Click Chips conjunction...
The method for the simulational generation of Gaussian correlation random surfaces is proposed,and computational simulation speckle field produced by this kind on Fraunhofer plane performed.10000 fieldsamples at each