A5016270629- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Neuroscience and Neural Engineering
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Electrochemical Analysis and Applications
- Organic Electronics and Photovoltaics
- Force Microscopy Techniques and Applications
- Luminescence and Fluorescent Materials
- Supercapacitor Materials and Fabrication
- Supramolecular Self-Assembly in Materials
- Extracellular vesicles in disease
- Covalent Organic Framework Applications
- Graphene and Nanomaterials Applications
- Advanced Chemical Sensor Technologies
- Molecular Sensors and Ion Detection
- Fullerene Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Gas Sensing Nanomaterials and Sensors
- Cancer Genomics and Diagnostics
Academia Sinica
2014-2025
Institute of Chemistry, Academia Sinica
2016-2025
Institute of Bioengineering and Nanotechnology
2007-2024
Shanghai University
2022
China National Petroleum Corporation (China)
2021
National Taiwan University
1996-2020
National Yang Ming Chiao Tung University
2019-2020
RIKEN
2013-2018
RIKEN Center for Emergent Matter Science
2014-2018
The Medical Center of Aurora
2017
Nanobiointerfaces were prepared based on an electrically conductive polyethylenedioxythiophene (PEDOT). Thin (<100 nm), ultrasmooth (roughness (Rrms) < 5 and functionalized PEDOT films have been successfully electropolymerized using aqueous microemulsion. The microemulsion polymerization is found to be catalyzed in the presence of a low concentration acid allows for film formation from various ethylenedioxythiophenes (EDOTs) (e.g., EDOT-OH, C2-EDOT-COOH, C4-EDOT-COOH, C2-EDOT-NHS, EDOT-N3)...
A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration ligand-receptor recognition, nanostructure amplification, thermal responsive polymers enables a highly efficient selective cancer cells. Subsequently, these captured are released upon physical stimulation with outstanding cell viability.
Abstract We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier creates more opportunities curative therapeutic interventions. EVs are present in circulation at relatively stages disease, providing potential detection. develop an EV (i.e., Click Chips) synergistically integrating chemistry-mediated capture/release, multimarker antibody...
Dynamic nuclear polarization (DNP) experiments in rotating solids have been performed for the first time using biradicals rather than monomeric paramagnetic centers as polarizing agents. Specifically, two TEMPO radicals were tethered with a poly(ethylene glycol) chain of variable length where number glycol units was 2, 3, or 4. NMR show that signal observed DNP is approximately inversely proportional to chain. Thus, shorter larger electron dipolar couplings yields enhancements. The size...
Water-soluble and stable quantum dots (QDs), CdTe CdZnSe, are applied for ultrasensitive Pb2+ detection. These QDs capped with glutathione (GSH) shells. GSH its polymeric form, phytochelatin, employed by nature to detoxify heavy metal ions. As a result of specific interaction, the fluorescence intensity GSH-capped is selectively reduced in presence ions such as Pb2+. The detection limit found be 20 nM due superior properties QDs. Detailed studies spectroscopy, microscopy, dynamic light...
To date, the cross effect (CE) and thermal mixing (TM) mechanisms have consistently provided largest enhancements in dynamic nuclear polarization (DNP) experiments performed at high magnetic fields. Both involve a three-spin electron-electron-nucleus process whose efficiency depends primarily on two electron-electron interactions--the interelectron distance R correct electron paramagnetic resonance (EPR) frequency separation that matches Larmor frequency, /omega(e2)-omega(e1)/ = omega(n)....
Nanostructured conducting polymer nanodots are prepared by electropolymerization of carboxylic acid group functionalized monomer in dichloromethane directly onto substrates. They demonstrate enhanced yields for the capture tumor cells compared to smooth surfaces due a synergistic effect agents and nanostructures. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. made available submitted authors....
Various nanostructures, including nanofibers, nanodots, nanonetwork, and nano- to microsize tubes of functionalized poly(3,4-ethylenedioxythiophene) (EDOT) poly(3,4-propylenedioxythiophene) (ProDOT) are created by using a template-free electropolymerization method on indium-tin-oxide substrates. By investigating conducting polymer nanostructures containing various functional groups prepared at different polymerization temperature, we conclude synergistic effect temperature the formation when...
Abstract Resisting biomolecule adsorption onto the surface of brain‐implanted microelectrodes is a key issue for in vivo monitoring neurochemicals. Herein, we demonstrate that an ultrathin cell‐membrane‐mimic film ethylenedioxythiophene tailored with zwitterionic phosphorylcholine (EDOT‐PC) electropolymerized carbon fiber microelectrode (CFE) not only resists protein but also maintains sensitivity and time response dopamine (DA). As consequence, as‐prepared PEDOT‐PC/CFEs could be used as new...
Unlike tumor biopsies that can be constrained by problems such as sampling bias, circulating cells (CTCs) are regarded the "liquid biopsy" of tumor, providing convenient access to all disease sites, including primary and fatal metastases. Although enumerating CTCs is prognostic significance in solid tumors, it conceivable performing molecular functional analyses on will reveal much significant insight into biology guide proper therapeutic intervention. We developed Thermoresponsive...
In this study we synthesized two tetraphenyl-p-phenylenediamine-based covalent organic frameworks (TPPDA-TPPyr and TPPDA-TPTPE COFs) for potential use in high-performance electrochemical supercapacitors. This excellent performance arose from their structures containing redox-active triphenylamine derivatives high surface areas.
Abstract In this paper we report the construction of a hollow microtubular triazine‐ and benzobisoxazole‐based covalent organic framework (COF) presenting sponge‐like shell through template‐free [3+2] condensation planar molecules 2,4,6‐tris(4‐formylphenyl)triazine (TPT‐3CHO) 2,5‐diaminohydroquinone dihydrochloride (DAHQ‐2HCl). The synthesized COF exhibited extremely high crystallinity, surface area (ca. 1855 m 2 g −1 ), ultrahigh thermal stability. Interestingly, time‐dependent study...
In this study, we examined the influence of functionalized poly(3,4-ethylenedioxythiophene) (PEDOT) nanostructures decorated on channel layer an organic electrochemical transistor (OECT) for detection sweat cortisol, adrenocorticosteroid stress hormone. The OECT device featured a bilayer confined by PEDOT:polystyrenesulfonate (PSS) underlayer and nanostructure-decorated upper engineered from monomers EDOT-COOH EDOT-EG3 through template-free polymerization. This molecular design allowed...
Abstract: Carboxyfullerene, a water‐soluble carboxylic acid derivative of fullerene, was investigated as protective agent against iron‐induced oxidative stress in the nigrostriatal dopaminergic system anesthetized rats. Intranigral infusion exclusive carboxyfullerene did not increase lipid peroxidation substantia nigra or deplete dopamine content striatum. Infusion ferrous citrate (iron II) induced degeneration system. An well decreases K + ‐evoked overflow and striatum were observed 7 days...
Various substituted dioxythiophenes bearing 3,4-propylenedioxythiophenes (ProDOT) and 3,4-ethylenedioxythiophene (EDOT) moieties successfully undergo Pd-catalyzed direct C–H arylation to yield π-conjugated polymers. The effects of palladium catalysts, phosphine ligands or additives, functional groups on this facile polycondensation approach are investigated. Polymers from alkoxy-substituted ProDOT synthesized with reasonable molecular weight (Mn = 6100–9600) low PDI (1.3–1.9). Four EDOT...
Abstract Nanostructures of poly(3,4‐ethylenedioxythiophene) (PEDOT) are assembled by using an anodic aluminum oxide template directly fabricated on gold‐coated silicon wafers. Inside these templates, PEDOT and hydroxy functionalized form tubes. On the other hand, alkyl‐ perfluoro‐functionalized PEDOTs as nanorods. This approach allows a platform to understand molecular nanostructural effect surface wettability materials. In water/air interface, contact angle water droplet (CA ) for smooth...
Tailoring the surface of biometallic implants with protein-resistant polymer brushes represents an efficient approach to improve biocompability and mechanical compliance soft human tissues. A general utilizing electropolymerization form initiating group (-Br) containing poly(3,4-ethylenedioxythiophen)s (poly(EDOT)s) is described. After conducting deposited, neutral poly((oligo(ethylene glycol) methacrylate), poly(OEGMA), zwitterionic...
Circulating fetal nucleated cells (CFNCs) in maternal blood offer an ideal source of genomic DNA for noninvasive prenatal diagnostics (NIPD). We developed a class nanoVelcro microchips to effectively enrich subcategory CFNCs, i.e., circulating trophoblasts (cTBs) from blood, which can then be isolated with single-cell resolution by laser capture microdissection (LCM) technique downstream genetic testing. first established nanoimprinting fabrication process prepare the LCM-compatible...
Well-preserved molecular cargo in circulating extracellular vesicles (EVs) offers an ideal material for detecting oncogenic gene alterations cancer patients, providing a noninvasive diagnostic solution detection of disease status and monitoring treatment response. Therefore, technologies that conveniently isolate EVs with sufficient efficiency are desperately needed. Here, lipid labeling click chemistry-based EV capture platform ("Click Beads"), which is message ribonucleic acid (mRNA)...
Segmented conducting polymers based upon a calix[4]arene scaffold are reported. The cone conformation creates zigzag orientation of the polymer segments. Their acid-dependent conductivities similar to strong pH conductivity dependence polyaniline which is said be acid dopable. On other hand, they have segmented structure that imposes greater localization carriers. such system can considered result from rapid self-exchange between discrete units. Hence, electron exchange radical cations and...