A5080719636- Cancer Cells and Metastasis
- Advancements in Battery Materials
- Cancer Genomics and Diagnostics
- 3D Printing in Biomedical Research
- Supercapacitor Materials and Fabrication
- Advanced Battery Materials and Technologies
- Advanced biosensing and bioanalysis techniques
- Advanced battery technologies research
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Mass Spectrometry Techniques and Applications
- Electrocatalysts for Energy Conversion
- Microfluidic and Bio-sensing Technologies
- Analytical chemistry methods development
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Photocatalysis Techniques
- Advanced Biosensing Techniques and Applications
- Electrochemical sensors and biosensors
- Nanoplatforms for cancer theranostics
- Prenatal Screening and Diagnostics
- Single-cell and spatial transcriptomics
- Biosensors and Analytical Detection
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
Suzhou Institute of Nano-tech and Nano-bionics
2023-2025
Chinese Academy of Sciences
2006-2025
South China Normal University
2018-2025
Lanzhou University
2023-2025
Lanzhou University Second Hospital
2023-2025
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Henan Agricultural University
2024
Peking University Shenzhen Hospital
2013-2024
A platform for capture and release of circulating tumor cells (CTCs) is demonstrated by utilizing aptamer grafted silicon nanowires. Here, single-stranded DNA-aptamers are generated via the Cell-SELEX process to serve as agents, allowing specific non-small cell lung cancer (NSCLC) CTCs from whole-blood samples with minimum contamination negligible disruption CTC viability functions.
A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration ligand-receptor recognition, nanostructure amplification, thermal responsive polymers enables a highly efficient selective cancer cells. Subsequently, these captured are released upon physical stimulation with outstanding cell viability.
Confined to one cell: A method detect and isolate single circulating melanoma cells (CMCs; see figure) has been produced by integrating a polymer-nanofiber-embedded nanovelcro cell-affinity assay with laser microdissection (LMD) technique. This is able separate CMCs from normal white blood (WBCs) sequence individual for specific mutation related cancer progression, allowing more personalized therapy. As service our authors readers, this journal provides supporting information supplied the...
The lack of available protons severely lowers the activity alkaline hydrogen evolution reaction process than that in acids, which can be efficiently accelerated by tuning coverage and chemical environment on catalyst surface. However, cycling active sites proton transfer is largely dependent utilization noble metal catalysts because appealing electronic interaction between atoms protons. Herein, an all-non-noble W/WO2 metallic heterostructure serving as efficient solid-acid exhibits...
Handpick single cancer cells: A modified NanoVelcro Chip is coupled with ArcturusXT laser capture microdissection (LCM) technology to enable the detection and isolation of circulating tumor cells (CTCs) from patients prostate (PC). This new approach paves way for conducting next-generation sequencing (NGS) on CTCs. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not...
Current diagnosis and staging of pancreatic ductal adenocarcinoma (PDAC) has important limitations better biomarkers are needed to guide initial therapy. We investigated the performance circulating tumour cells (CTCs) as an adjunctive biomarker at time disease presentation. Venous blood (VB) was collected prospectively from 100 consecutive, pre-treatment patients with PDAC. Utilising microfluidic NanoVelcro CTC chip, samples were evaluated for presence number CTCs. KRAS mutation analysis...
Unlike tumor biopsies that can be constrained by problems such as sampling bias, circulating cells (CTCs) are regarded the "liquid biopsy" of tumor, providing convenient access to all disease sites, including primary and fatal metastases. Although enumerating CTCs is prognostic significance in solid tumors, it conceivable performing molecular functional analyses on will reveal much significant insight into biology guide proper therapeutic intervention. We developed Thermoresponsive...
An efficient nonviral platform for high-throughput and subcellular precision targeted intracellular delivery of nucleic acids in cell culture based on magnetic nanospears is reported. These are made Au/Ni/Si (∼5 μm length with tip diameters <50 nm) fabricated by nanosphere lithography metal deposition. A magnet used to direct the mechanical motion a single nanospear, enabling precise control position three-dimensional rotation. were further functionalized enhanced green fluorescent protein...
BACKGROUND Although enumeration of circulating tumor cells (CTCs) has shown some clinical value, the pool CTCs contains a mixture that additional information can be extracted. The authors subclassified by shape features focusing on nuclear size and related this with information. METHODS A total 148 blood samples were obtained from 57 patients prostate cancer across spectrum metastatic states: no metastasis, nonvisceral visceral metastasis. captured enumerated NanoVelcro Chips (CytoLumina,...
// Runze Jiang 1, † , Yi-Tsung Lu 2, Hao Ho 3, 4, Bo Li Jie-Fu Chen 5 Millicent Lin Fuqiang 1 Kui Wu Hanjie Jake Lichterman 2 Haolei Wan 6 Chia-Lun William OuYang Ming Ni Linlin Wang Guibo Tom Lee 7 Xiuqing Zhang 8 Jonathan Yang Matthew Rettig 9, 10 Leland W.K. Chung * Huanming 11, 12, Ker-Chau Yong Hou Hsian-Rong Tseng 5, 7, Shuang Xun Xu Jun 13, Edwin M. Posadas Beijing Genome Institute-Shenzhen, Shenzhen 51803, China Urologic Oncology Research Program, Cedars-Sinai Medical Center, Los...
Hepatocellular carcinoma (HCC) is a leading cause of mortality. Checkpoint inhibitors programmed cell death protein‐1 (PD‐1) and death‐ligand 1 (PD‐L1) have shown great efficacy, but lack biomarkers that predict response. Circulating tumor cells (CTCs) promise as liquid‐biopsy biomarker; however, data on HCC CTCs expressing PD‐L1 not been reported. We sought to detect PD‐L1‐expressing HCC‐CTCs investigated their role prognostic predictive biomarker. Using an antibody‐based platform, were...
Currently, the construction of an acid-like catalyst surface in a high-pH electrolyte is advocated as one most pioneering strategies for significantly improving catalytic activity alkaline hydrogen evolution reaction. However, proton transfer kinetics that determines proton-coupled electron reaction largely dependent on usage extensive noble-metal bulk phase. Herein, well-designed dynamic system constructed by metallic WO2 matrix and supported Ru single atoms (0.89 wt %) grown nickel foam...
Transition-metal carbides have been advocated as the promising alternatives to noble-metal platinum-based catalysts in electrocatalytic hydrogen evolution reaction over half a century. However, effectiveness of transition-metal catalyzing high-pH electrolyte is severely compromised due lowered proton activity and intractable alkaline-leaching issue centers. Herein, on basis validation molybdenum-carbide model-catalyst system by taking advantage surface science techniques, Mo2C micro-size...
The clinical practice of oncology is being transformed by molecular diagnostics that will enable predictive and personalized medicine. Current technologies for quantitation the cancer proteome are either qualitative (e.g., immunohistochemistry) or require large sample sizes flow cytometry). Here, we report a microfluidic platform-microfluidic image cytometry (MIC)-capable quantitative, single-cell proteomic analysis multiple signaling molecules using only 1,000 to 2,800 cells. Using cultured...
Circulating tumor cells (CTCs) have emerged as promising tools for noninvasive cancer detection and prognosis. Most conventional approaches capturing CTCs use an EpCAM-based enrichment strategy, which does not work well in cancers that show low or no expression of EpCAM, such renal cell carcinoma (RCC). In this study, we developed a new set surface markers including CA9 CD147 alternative CTC-capture antigens specifically designed RCC patients. We showed the both was prevalent patient cohort...
Circulating fetal nucleated cells (CFNCs) in maternal blood offer an ideal source of genomic DNA for noninvasive prenatal diagnostics (NIPD). We developed a class nanoVelcro microchips to effectively enrich subcategory CFNCs, i.e., circulating trophoblasts (cTBs) from blood, which can then be isolated with single-cell resolution by laser capture microdissection (LCM) technique downstream genetic testing. first established nanoimprinting fabrication process prepare the LCM-compatible...
A pretargeted oncologic positron emission tomography (PET) imaging that leverages the power of supramolecular nanoparticles with in vivo bioorthogonal chemistry was demonstrated for clinically relevant problem tumor imaging. The advantages this approach are (i) pharmacokinetics (PKs) tumor-targeting and agents can be independently altered via chemical alteration to achieve desired performance (ii) interplay between two PKs other controllable variables confers a second layer control toward...
Current clinicopathologic staging systems and serum biomarkers poorly discriminate tumor biology in hepatocellular carcinoma (HCC), with high recurrence rates following curative‐intent surgical resection liver transplantation (LT). Identification of accurate for improved prognostication treatment selection is a critical unmet need. We sought to develop novel “liquid‐biopsy” assay capable detecting HCC circulating cells (CTCs) characterizing phenotypic subpopulations prognostic significance....