A5009046503- Blood properties and coagulation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Platelet Disorders and Treatments
- Microfluidic and Bio-sensing Technologies
- Traffic and Road Safety
- Safety Warnings and Signage
- 3D Printing in Biomedical Research
- Rheology and Fluid Dynamics Studies
- Fluid Dynamics and Thin Films
- Pickering emulsions and particle stabilization
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Fluid Dynamics and Heat Transfer
- Traditional Chinese Medicine Studies
- Liver Disease Diagnosis and Treatment
- Transportation Safety and Impact Analysis
- Occupational Health and Safety Research
- Cancer Cells and Metastasis
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Ideological and Political Education
- Antiplatelet Therapy and Cardiovascular Diseases
- Fault Detection and Control Systems
Guangzhou University of Chinese Medicine
2018-2025
Zhejiang Wanli University
2025
Xi'an Medical University
2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
Fujian Medical University
2024
Chengdu University of Traditional Chinese Medicine
2022-2024
Chinese PLA General Hospital
2023
Xi'an Jiaotong University
2013-2022
Shandong Women’s University
2022
Southwest Jiaotong University
2022
To enhance exploration on tumor stem-like cells (TSCs) without altering their cellular biological characteristics, researchers advocate for application of single-cell-derived tumor-spheres (STSs). TSCs are regulated by surrounding microenvironment, making it crucial to simulate a microenvironment facilitate STS formation. Recently, exosomes that originated from the have emerged as promising approach mimicking microenvironment. In various associated (such fibroblasts, endothelial cells, and...
Handpick single cancer cells: A modified NanoVelcro Chip is coupled with ArcturusXT laser capture microdissection (LCM) technology to enable the detection and isolation of circulating tumor cells (CTCs) from patients prostate (PC). This new approach paves way for conducting next-generation sequencing (NGS) on CTCs. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not...
The deformation of a compound capsule (an elastic with smaller inside) in simple shear flow is studied by using three-dimensional numerical simulations based on front tracking method. inner and outer capsules are concentric initially spherical. Skalak et al. ’s constitutive law employed for the mechanics both membranes. Our results concerning homogeneous (i.e. without capsules) quantitatively agreement predictions previous perturbation theories. Compared to capsules, exhibit deformation....
Despite its significance in various applications, e.g., droplet microfluidics and chemical enhanced oil recovery, the motion of surfactant-laden droplets non-circular microchannels remains an unsolved fundamental problem. To facilitate studies this area, we present a systematic investigation on covered with insoluble surfactant square microchannel. This work is realized via our three-dimensional front-tracking finite-difference model integration convection-diffusion equation for transport...
Lithium-sulfur (Li-S) batteries are highly attractive due to their exceptional theoretical energy density (2600 Wh kg-1) and low cost. However, practical deployment is limited by critical issues, including pronounced polysulfide shuttling slow reaction kinetics. In this study, we report the development of a novel Mo-Zn bimetallic ZIF-8 catalyst designed address these issues. Compared with pristine ZIF-8, Mo-ZIF-8 exhibited an effectively tuned surface area pore structure, significantly...
Summary Objectives This study sought to evaluate the influence of genetic polymorphisms on platelet reactivity and clinical outcomes in acute ischemic stroke patients taking clopidogrel. Background Little research has been published relationships between polymorphisms, reactivity, treated with Methods Patients hospitalized Changhai Hospital were randomly enrolled into treatment a 75‐mg daily maintenance dose Genotyping was detected by Mass ARRAY iPLEX genotyping system (Sequenom Inc, San...
A three-dimensional (3D) simulation study of the effect inertia on dynamics vesicles and red blood cells (RBCs) has not been reported. Here, we developed a 3D model based front tracking method to investigate how affects spherical/non-spherical biconcave-shaped RBCs with Reynolds number ranging from 0.1 10. The results showed that induced non-spherical transitioned tumbling swinging, which was observed in previous 2D models. critical viscosity ratio inner/outer fluids for tumbling–swinging...
The dynamics of an initially ellipsoidal compound capsule in a simple shear flow is investigated numerically using three-dimensional front-tracking finite-difference model. Membrane bending resistance included based on Helfrich’s energy function besides the resistances against deformation and area dilatation governed by constitutive law Skalak et al. In this paper, we focus specifically how presence spherical inner its size affects characteristics transition various dynamical states...
Surfactants are widely used in the manipulation of drop motion microchannels, which is commonly involved many applications, e.g., surfactant assisted oil recovery and droplet microfluidics. This study dedicated to a crucial fundamental problem, i.e., effects soluble on their underlying mechanisms, an extension our previous work insoluble-surfactant-covered square microchannel [Z. Y. Luo, X. L. Shang, B. F. Bai, “Marangoni effect covered with insoluble microchannel,” Phys. Fluids 30, 077101...
Each year numerous pedestrian and bicyclist crashes involving high injury levels are reported at highway–rail grade crossings (HRGCs) across the United States. Such invariably result of errors on part pedestrians bicyclists. The focus this paper is to investigate violations a dual-quadrant gated HRGC report four types gate violations, including factors associated with those violations. For both bicyclists, studied were (a) passing under descending gates, (b) around fully lowered (c)...
We study numerically the dynamics of an insoluble surfactant-laden droplet in a simple shear flow taking surface viscosity into account. The rheology drop is modelled via Boussinesq–Scriven constitutive law with both tension and depending strongly on concentration surfactant. Our results show that exhibits non-trivial effects surfactant transport deforming surface. Specifically, dilatational tend to eliminate non-uniformity over However, their underlying mechanisms are entirely different;...
Previous studies on capsule dynamics in shear flow have dealt with Newtonian fluids, while the effect of fluid viscoelasticity remains an unresolved fundamental question. In this paper, we report a numerical investigation capsules enclosing viscoelastic and which are freely suspended under simple shear. Systematic simulations performed at small but non-zero Reynolds numbers (i.e. $Re=0.1$ ) using three-dimensional front-tracking finite-difference model, is introduced via Oldroyd-B...
Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, Cremophor EL (polyethoxylated castor oil), toxic surfactant, used for dissolution of PTX, which accounts serious side effects. the present study, single glucose-conjugated PTX prodrug (SG-PTX) and double (DG-PTX) were synthesized glycosylated strategy via succinate linkers. Both two prodrugs presented significant solubility improvement drug-like lipophilicities. Compared to DG-PTX, SG-PTX...
Due to the significance of understanding underlying mechanisms cell adhesion in biological processes and capture biomedical applications, we numerically investigate dynamics deformable capsules under shear flow by using a three-dimensional computational fluid dynamic model. This model is based on coupling front tracking-finite element method for elastic mechanics capsule membrane kinetics simulation adhesive interactions between functionalized surfaces. Using this model, three distinct...
Nanoparticle surfactants, formed at liquid–liquid interfaces by the interactions between functional groups on nanoparticles and polymers having complementary end-functionality, have been recently proposed as an excellent interface stabilizer to cover liquid droplets for applications of substance encapsulation delivery. However, effects nanoparticle surfactants production in a microfluidic channel not comprehensively understood yet, which is key prerequisite achieving various functions real...
Abstract Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, mechanism action CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny. Objective: The objective this study was to explore regulatory metabolism NAFLD. Methods: Components ethanol extract (CSEE) were analyzed and identified using UPLC-Q-Orbirap HRMS. candidate compounds its relative targets extracted from Traditional Chinese Medicine Systems...
Compared with centered capsules, off-centerline capsules are easier to get stuck, their membranes presenting a tank-treading rotation at the constriction inlet.
Despite its significance in droplet-based microfluidic technologies with the use of thermal stimuli and surfactants, coupling effects thermal- surfactant-induced Marangoni stresses on transport droplets microchannels are not fully uncovered yet. To facilitate studies this area, we present a three-dimensional numerical study thermocapillary migration an insoluble-surfactant-laden droplet under Poiseuille flow microchannel. This work is realized via our own front-tracking finite-difference...