A5100663086- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Influenza Virus Research Studies
- Advanced battery technologies research
- Supercapacitor Materials and Fabrication
- Nanoplatforms for cancer theranostics
- Aerosol Filtration and Electrostatic Precipitation
- Advanced Battery Technologies Research
- Air Quality Monitoring and Forecasting
- Air Quality and Health Impacts
- interferon and immune responses
- Silicon and Solar Cell Technologies
- Extraction and Separation Processes
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Atmospheric aerosols and clouds
- Semiconductor materials and interfaces
- Conducting polymers and applications
- MXene and MAX Phase Materials
- Autophagy in Disease and Therapy
- Vehicle emissions and performance
- Immune cells in cancer
- Thin-Film Transistor Technologies
- Transition Metal Oxide Nanomaterials
Zhejiang Wanli University
2024-2025
Gansu Provincial Hospital
2024
Chinese Academy of Sciences
2021-2024
Changchun Institute of Applied Chemistry
2021-2024
University of Science and Technology of China
2016-2024
Zhejiang University
2020-2024
South China Normal University
2022-2024
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Shanghai Advanced Research Institute
2024
The ABC1 transporter was identified as the defect in Tangier disease by a combined strategy of gene expression microarray analysis, genetic mapping, and biochemical studies. Patients with have cellular cholesterol removal, which results near zero plasma levels HDL massive tissue deposition cholesteryl esters. Blocking or activity reduces apolipoprotein-mediated lipid efflux from cultured cells, increasing enhances it. is induced loading cAMP treatment reduced upon subsequent removal...
Single-atom catalysts (SACs) pave new possibilities to improve the utilization efficiency of sulfur electrodes arising from polysulfide shuttle effects and sluggish kinetics due their excellent applicability in atomic-scale reaction mechanisms structure-activity relationships. Herein, nitrogen (N)-anchored SACs on highly ordered N-doped carbon nanotube arrays are reported as host for fast redox conversion lithium-sulfur (Li-S) batteries. The cube structure aligned nanotubes can promote rapid...
Abstract Lithium–sulfur batteries have received extensive interest owing to their exceptionally high energy density. Nonetheless, practical implementation is still impeded by the shuttle effect of polysulfides and sluggish conversion kinetics. Considering that, a porous 2D defective zeolitic imidazolate framework‐7 (ZIF‐7) with abundant active edges rationally designed as multifunctional sulfur carriers for Li–S batteries. The ZIF‐7 enables uniform distribution rapid Li‐ion diffusion, while...
Abstract Lithium–sulfur (Li–S) batteries promise high theoretical energy density and cost‐effectiveness but grapple with challenges like the polysulfide shuttle effect sluggish kinetics. Metal–organic framework (MOF) catalysts emerge as a leading solution, despite limited conductivity steric hindrance. This study employs undercoordination chemistry to modify Zn–Co bimetallic MOFs (D‐ZIF L), removing organic ligands from active centers. process mitigates spatial hindrance, thereby promoting...
Previous studies have shown that ferroptosis of vascular smooth muscle cells (VSMCs) is involved in the development aortic dissection (AD) and histone methylation regulates this process. SP2509 acts as a specific inhibitor lysine-specific demethylase 1 (LSD1), which governs variety biological processes. However, effect on VSMC AD remains to be elucidated. This aim study was investigate role underlying mechanism SP2509-mediated ferroptosis. Here, mouse model established, significantly reduced...
The activity of cyclin-dependent kinase 2 (CDK2) is essential for progression cells from G1 to the S phase mammalian cell cycle. CVT-313 a potent CDK2 inhibitor, which was identified purine analog library with an IC50 0.5 μm in vitro. Inhibition competitive respect ATP (K i = 95 nm), and selective had no effect on other, nonrelated ATP-dependent serine/threonine kinases. When added CDK1 or CDK4, 8.5- 430-fold higher concentration required half-maximal inhibition enzyme activity. In exposed...
Lithium–sulfur (Li–S) batteries are hindered by the undesired shuttle effect and sluggish electrochemical conversion kinetics. Herein, a well‐designed CoFe 2 O 4 @reduced graphene oxide (CFO@rGO) composite is used to modify separator develop multifunctional polysulfide barrier. Density functional theory (DFT) calculations confirm that highly electronegative oxygen ions in CFO tend bond with transition metal (TM) at octahedral (O h ) sites, which induces formation of FeS CoS bonds between...
Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, plays a critical role in the host antiviral response. However, mechanism and spectrum of TRIM21 influenza A virus (IAV) remain unclear. Here, we report that inhibits replication various IAV subtypes by targeting matrix 1 (M1) from H3/H5/H9, but not H1 H7 M1. Mechanistically, binds to residue R95 M1 facilitates K48 ubiquitination K242 for proteasome-dependent degradation, leading inhibition H3, H5, H9 replication....
Abstract Lithium–sulfur (Li–S) batteries stand out as a promising candidate for future energy storage, characterized by their notable density and affordability. However, the impediments raised polysulfide shuttling sluggish reaction kinetics pose substantial challenges to widespread implementation of this technology. Herein, unique Fe–Co bimetallic single‐atom‐cluster catalyst (FeCo‐SACC) Li–S are developed. The synergistic integration single atoms clusters guarantees not only commendable...
Iron metabolism is involved in numerous physiological processes such as erythropoiesis, oxidative metabolism. However, the vivo functions of iron metabolism-related gene Hfe immune response during viral infection remain poorly understood. Here, we identified 5 metabolism-associated genes specifically affected RNA virus by a high-throughput assay and further found that HFE was key negative regulator RIG-I-like receptors (RLR)-mediated type I interferons (IFNs) signaling. inhibited binding to...
Induction of immunogenic cell death (ICD) by hyperthermia can initiate adaptive immune responses, emerging as an attractive strategy for tumor immunotherapy. However, ICD induce proinflammatory factor interferon-γ (IFN-γ) production, leading to indoleamine 2,3-dioxygenase 1 (IDO-1) activation and immunosuppressive microenvironment, which dramatically reduces the ICD-triggered immunotherapeutic efficacy. Herein, we developed a bacteria-nanomaterial hybrid system (CuSVNP20009NB) systematically...
Lithium-sulfur (Li-S) batteries are highly attractive due to their exceptional theoretical energy density (2600 Wh kg-1) and low cost. However, practical deployment is limited by critical issues, including pronounced polysulfide shuttling slow reaction kinetics. In this study, we report the development of a novel Mo-Zn bimetallic ZIF-8 catalyst designed address these issues. Compared with pristine ZIF-8, Mo-ZIF-8 exhibited an effectively tuned surface area pore structure, significantly...
Developing efficient catalysts is essential for mitigating the shuttle effect and accelerating conversion kinetics of polysulfides in lithium-sulfur (Li-S) batteries. To date, numerous strategies have been employed to optimize...
A thin layers graphene-encapsulated Na<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub>(NVP/G) has been in the spotlight as a potential candidate of next generation batteries to compensate intrinsic low electronic conductivity NVP and strengthen its structure stable.
Autophagy can be utilized by influenza A virus (IAV) to facilitate its replication. However, whether autophagy is induced at the stage of IAV entry still unclear. Here, we report that induces hemagglutinin (HA) binding heat shock protein 90AA1 (HSP90AA1) distributed on cell surface. Virus overlay assay and pull down indicated HA bound directly surface HSP90AA1. Knockdown HSP90AA1 weakened H1N1 infection. Incubation viral particles with recombinant or prior blockade A549 cells anti-HSP90AA1...
Obesity treatment is a global public health challenge due to inadequate weight loss and regain even after endeavors with multimodal treatments. Considering the abundance of resident macrophages in adipose tissues, precise regulation interactions between adipocytes may provide chances for immunotherapy obesity. Herein, inspired by phagocytosis clear apoptotic cells homeostasis, an strategy obesity proposed first time through camouflage PA Au BPs activate clearance, where are gold...
ZnO nanorods were used to prepare n Ag/r-ZnO photocatalysts with promoted carrier separation, and an excellent oxygenate (CH 3 OOH, CH OH, HCHO) yield of 15 551.60 μmol g −1 h a high selectivity 98.46% thus obtained during photooxidation 4 .