A5101911197- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Fungal and yeast genetics research
- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Topic Modeling
- Virus-based gene therapy research
- Circular RNAs in diseases
- Fungal Infections and Studies
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- 3D Printing in Biomedical Research
- Respiratory and Cough-Related Research
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Nail Diseases and Treatments
- Antifungal resistance and susceptibility
- Drug Transport and Resistance Mechanisms
- Natural Language Processing Techniques
Hangzhou Children's Hospital
2018-2024
Shanghai Jiao Tong University
2017-2024
Huawei Technologies (Sweden)
2023
Dalian University of Technology
2023
Vanderbilt University
2007-2020
Nanjing Medical University
2019
Southeast University
2011-2015
Zhongda Hospital Southeast University
2012
Howard Hughes Medical Institute
2007
Polyploidy is associated with increased cell size and commonly found in a subset of adult organs blastomere stage the human embryo. The polyploidy formed through endoreplication or fusion to support specific need development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program response oncogenic therapeutic stress generate reprogrammed cancer cells for drug resistance metastasis....
Cancer stem cells (CSCs) are believed to be 'seed cell' in cancer recurrence and metastasis. MicroRNAs (miRNAs) can play an important role the progression of primary tumor towards metastasis by regulating epithelial-mesenchymal transition (EMT). The goal this study was investigate effect miRNA-200c overexpression on EMT, tumorigenicity epithelial ovarian (EOC) CSCs.The EOC CD117+CD44+CSCs were isolated from human cell line SKOV3 using a magnetic-activated sorting system, lentivirus miR-200c...
Abstract Background Cancer stem cells (CSCs) are thought to be capable of surviving conventional chemotherapeutic treatments because the have more resistant anticancer drugs than common cancer cells. Most in vitro studies experimental been done a two-dimensional (2D) monocultures, while accumulating evidence suggests that behave differently when they grown within three-dimensional (3D) culture system. Results The CD44 + CD117 isolated from human epithelial ovarian SKOV-3 cell line using...
To investigate the effects of anti-ABCG2 monoclonal antibodies (mAbs) in combination with paclitaxel iron oxide nanoparticles (PTX-NPs) on CD138(-)CD34(-) multiple myeloma (MM) cancer stem cells (CSCs) JJN3 cells.PTX-NPs were prepared using hydrophobic interaction polyoxypropylene chain and oleic acid surface NPs targeted to ABCG2 transporter overexpressing MM CSCs mAbs.The data showed that have strong drug resistance tumorigenicity compared non-MM CSCs. PTX-NPs combined mAbs led a...
This paper presents SANA-1.5, a linear Diffusion Transformer for efficient scaling in text-to-image generation. Building upon SANA-1.0, we introduce three key innovations: (1) Efficient Training Scaling: A depth-growth paradigm that enables from 1.6B to 4.8B parameters with significantly reduced computational resources, combined memory-efficient 8-bit optimizer. (2) Model Depth Pruning: block importance analysis technique model compression arbitrary sizes minimal quality loss. (3)...
The human umbilical cord mesenchymal stem cells (hUCMSCs) have the ability to migrate into tumors and therefore been considered as an alternative source of progenitors for therapy malignant diseases. present study was aimed investigate effect hUCMSCs vehicles a constant transgenic interleukin-21 (IL-21) on ovarian cancer in vivo. were engineered express IL-21 via lentiviral vector- designated 'hUCMSCs-LV-IL-21', then transplanted SKOV3 xenograft-bearing nude mice. therapeutic efficacy...
<h3>Background</h3> Progress has been made against early events of malignant transformation and drug resistance associated with epithelial ovarian cancer; uncontrolled metastases, however, still accounts for most patient deaths. The molecular mechanism that regulates the process cancer metastases is not yet clearly understood. purpose this study was to investigate effect down-regulating transcriptional repressor zinc-finger E-box–binding homeobox 1 (ZEB1) on an epithelial-mesenchymal...
Emerging evidence indicates that dysregulated long intervening non-coding RNA (lincRNA) HOTAIR correlates highly with tumor invasion and metastasis but a link between the high expression of metastatic cascade cancer stem cells (CSCs) needs to be further studied. The purpose this study was investigate effect down-regulated on tumorgeniesis epithelial ovarian (EOC) CSCs. CD117+CD44+CSCs were isolated from human EOC SKOV3 cell line by using magnetic-activated sorting system, then transfected...
Objective: Prediction of asthma in preschool children is challenging and lacks objective indicators. The aim to observe analyze the variances between impulse oscillometry (IOS) fractional expiratory nitric oxide (FeNO) with wheezing, establish a joint prediction model, explore diagnostic value combining IOS FeNO diagnosing among children. Patients methods: This study enrolled aged 3– 6 years wheezing June 2021 2022. They were categorized as asthmatic (n=104) or non-asthmatic (n=109) after...
Background: To explore the effects of downregulated multidrug-resistance P-glycoprotein (MDR1/ABCB1) and reversed in human A2780 ovarian cancer cells. Materials Methods: Three shRNAs targeting MDR1 gene were synthesized, cloned into plasmid pSUPER-enhanced green fluorescent protein 1 (EGFP1). The formed pSUPER-EGFP1-MDR1-shRNAs transfected cells, respectively, quantitative reverse transcription polymerase chain reaction western blot used respectively to determine expression. (MDR)...
https://github.com/reasoning-survey/Awesome-Reasoning-Foundation-Models Reasoning, a crucial ability for complex problem-solving, plays pivotal role in various real-world settings such as negotiation, medical diagnosis, and criminal investigation. It serves fundamental methodology the field of Artificial General Intelligence (AGI). With ongoing development foundation models, there is growing interest exploring their abilities reasoning tasks. In this paper, we introduce seminal models...
Abstract Ovarian cancer causes more deaths than any other of the female reproductive system, and its overall cure rate remains low. The present study investigated human umbilical blood mononuclear cell (UBMC)–derived mesenchymal stem cells (UBMC‐MSCs) as interleukin‐21 ( IL‐21 ) gene delivery vehicles for ovarian therapy in nude mice. MSCs were isolated from UBMCs expanded phenotyped by flow cytometry. Cultured differentiated into osteocytes adipocytes using appropriate media then UBMC‐MSCs...
Background: There is growing evidence that CD138 – CD34 cells may actually be tumor stem responsible for initiation and relapse of multiple myeloma. However, effective drugs targeted at are yet to developed. The purpose this study was investigate the inhibitory effect paclitaxel-loaded Fe 3 O 4 nanoparticles (PTX-NPs) on in myeloma-bearing mice. Methods: were isolated from a human U266 myeloma cell line using an immune magnetic bead sorting method then subcutaneously injected into mice with...
Significant amount of bone mass is lost during the process aging due to an imbalance between osteoblast-mediated formation and osteoclast-mediated resorption in marrow microenvironment, which leads net loss population, resulting pathogenesis osteoporosis. Firstly, differences proliferative capacity adipocyte or adipogenic differentiation mouse mesenchymal stem cells (MMSCs) senile model-derived (SMMSCs), as well mRNA expression OGN PPARγ2 were observed. Secondly, osteogenic abilities MMSCs...
In Schizosaccharomyces pombe, late mitotic events are coordinated with cytokinesis by the septation initiation network (SIN), an essential spindle pole body (SPB)-associated kinase cascade, which controls formation, maintenance, and constriction of cytokinetic ring. It is not fully understood how SIN temporally regulated, but it depends on activation GTPase Spg1, inhibited during interphase bipartite GTPase-activating protein Byr4-Cdc16. Cells particularly sensitive to modulation Byr4,...
Background: Fever-range hyperthermia or fever-range temperature (hereafter FRT) improves survival and shortens disease duration in microbial infections. However, the mechanisms of these beneficial effects still remain elusive. We hypothesized that FRT might enhance cell responsiveness to infections by promoting cGAS-STING signaling cause enhanced production IFN-β.Objective: To investigate effect on pathway.Methods: RAW 264.7 cGAS-/- cells, stimulated with 5μg/ml herring testis DNA (htDNA),...
Cellular polarization underlies many facets of cell behavior, including growth. The rod-shaped fission yeast Schizosaccharomyces pombe is a well-established, genetically tractable system for studying growth polarity regulation. S. cells elongate at their two tips in cycle-controlled manner, transitioning from monopolar to bipolar interphase when new ends established by the most recent division begin extend. We previously identified cytokinesis as critical regulator end and demonstrated that...
Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to participate HASMC migration. We aimed explore more effects molecular mechanism taurine upregulated gene 1 (TUG1) asthma.TUG1 SMURF2 were overexpressed miR-216a-3p was downregulated asthma patients PDGF-BB-stimulated HASMCs. TUG1 knockdown attenuated PDGF-BB-triggered MiR-216a-3p targeted by TUG1,...
Chromosome segregation and cell division are coupled to prevent aneuploidy death. In the fission yeast Schizosaccharomyces pombe, septation initiation network (SIN) promotes cytokinesis, but upon mitotic checkpoint activation, SIN is actively inhibited cytokinesis from occurring before chromosomes have safely segregated. inhibition during mediated by E3 ubiquitin ligase Dma1. Dma1 binds CK1-phosphorylated scaffold protein Sid4 at spindle pole body (SPB), ubiquitinates it. ubiquitination...