A5085207355- Medicinal Plant Extracts Effects
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Maternal Mental Health During Pregnancy and Postpartum
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Gastrointestinal motility and disorders
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional Chinese Medicine Studies
- Education and Work Dynamics
- Computational Drug Discovery Methods
- Cholesterol and Lipid Metabolism
- Paraoxonase enzyme and polymorphisms
- Bioactive natural compounds
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Kruppel-like factors research
- Child and Adolescent Psychosocial and Emotional Development
- Protein Tyrosine Phosphatases
Chengdu University of Traditional Chinese Medicine
2015-2024
Chengdu University
2011-2023
Sichuan University
2020-2023
Southwest Jiaotong University
2022
Chongqing University of Arts and Sciences
2019
Chongqing University
2019
Abstract Valeriana jatamansi is widely used in Chinese folk medicine and contains iridoids as important active ingredients. The brain-gut axis describes a complex bidirectional system between the central nervous gastrointestinal tract. Herein, we evaluated antidepressant effects of total (TIV) preliminarily investigated gut microbiota on their using chronic, unpredictable mild-stress mouse model. Mice were given 5.7, 11.4, or 22.9 mg/kg TIV for 1 week. Fluoxetine (2.6 mg/kg) served positive...
Abstract Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, mechanism action CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny. Objective: The objective this study was to explore regulatory metabolism NAFLD. Methods: Components ethanol extract (CSEE) were analyzed and identified using UPLC-Q-Orbirap HRMS. candidate compounds its relative targets extracted from Traditional Chinese Medicine Systems...
Valeriana jatamansi Jones (V. jatamansi) has been widely used for treating anxiety and its mechanism involves many aspects including GABA level. This study aimed to evaluate the anxiolytic potency of an iridoid fraction extracted from radix rhizomes V. jatamansi. The was by using D101 resin; major components were analysed preliminarily thin layer chromatography, ultraviolet spectrophotometry high-performance liquid chromatography; effects at 6 mg/kg (low-dose), 9 (medium-dose) 12 (high-dose)...
Schisandrae chinensis fructus, the dried ripe fruit of Schisandra (Turcz.) Baill. (Magnoliaceae) has been used for thousands years as a traditional Chinese herb, which can attenuate and prevent development cardiovascular events.To evaluate effects ethanol extracts from fructus (EESC) on experimental atherosclerosis (AS) in rats.Treatment with EESC (0.35, 0.7, 1.4 g/kg/d, i.g.) simvastatin (4 mg/kg/d, AS rats 3 weeks. Sprague-Dawley normal chow under water treatment were control. The content...
Background: Usnea has various pharmacological properties, including anti-inflammatory, antitumor, antioxidant, antiviral, and cardiovasculoprotective effects. Aim of the study: To investigate potential mechanisms underlying anti-atherosclerosis (AS) activity ethanol extract (UEE) via regulation intestinal flora. Materials Methods: The chemical composition UEE was determined using ultra-performance liquid chromatography with quadrupole exactive orbitrap mass spectrometry (UPLC-Q-EOMS)....
This study aimed to decipher the bioactive compounds and potential mechanism of traditional Chinese medicine (TCM) formula Fuzi Lizhong Decoction (FLD) for nonalcoholic fatty liver disease (NAFLD) treatment via an integrative network pharmacology approach.The candidate FLD its relative targets were obtained from TCMSP PharmMapper web server, intersection genes NAFLD discerned using OMIM, GeneCards, DisGeNET. Then, PPI component-target-pathway networks constructed. Moreover, GO enrichment...
Abstract Background: Growing body of scientific researches in recent years have suggested the promising effect meditation on improving cognitive impairment Alzheimer disease (AD) and mild (MCI). This paper aims to provide a protocol for systematic review evaluate efficacy cognition performance patient with AD MCI. Methods: The Cochrane Library, PubMed, EMBASE, Web Science, Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang database, VIP information...
Valeriana jatamansi Jones [syn. V. wallichii DC, (Valerianaceae)] (VJJ) is used to treat depression.To explore the effects of total iridoids VJJ extract (TIV) on chronic unpredictable mild stress (CUMS) in mice.VJJ roots and rhizomes were extracted with 70% ethanol. CUMS rats treated daily fluoxetine (2.6 mg/kg, i.g.) or TIV (5.7, 11.4, 22.8 for 14 days. Male Kun Ming mice normal chow 0.5% CMC-Na solution as a control. Behavioural tests included tail suspension (TST) sucrose preference...
Alzheimer's disease (AD) is a common neurodegenerative disease. More evidence has shown that gut microbiota closely associated with AD. Also, studies have the distribution of vary in different sections intestine. In this study, rat model AD was established using bilateral intraventricular injection β-amyloid (1-42) [Aβ (1-42)], and behavior rats, hippocampal Aβ deposition, ileal colonic each group were analyzed. We observed rats had obvious memory cognitive impairment, increased indicating...
Early life stress alters gut microbiota and increases the risk of neuropsychiatric disorders, including social deficits anxiety, in host. However, role commensal bacteria early stress-induced neurobehavioral abnormalities remains unclear. Using maternally separated (MS) mice, our research has unveiled a novel aspect this complex relationship. We discovered that reduced levels amino acid transporters intestine MS mice led to low glutamine (Gln) blood synaptic dysfunction medial prefrontal...
This study aimed at exploring the active components and mechanisms of Jinhua Qinggan granules (JQG) in prevention treatment coronavirus disease 2019 (COVID-19) using network pharmacology molecular docking technology. These efforts were accomplished by employing holistic approach traditional Chinese medicine (TCM) considering virus-host interaction consisting viral characteristics, entry pathway into host, resulting immune response. The chemical constituents targets 12 herbs from JQG obtained...
One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display compound an outstanding promoting to PTP1B.
In this work, an electroanalytical platform for nereistoxin (NRT)-related insecticide detection is proposed on the basis of NRT induced DNA conformational switching and exonuclease III (Exo III) assisted target recycling. NRT-related insecticides were first hydrolyzed converted into with two thiol groups (-SH). Then, a cytosine-Ag+-cytosine (C-Ag+-C) mismatched base pair was adopted to induce blunt-ended hairpin configuration HP DNA. presence NRT, it could take up Ag+ from change its...
Growing evidence suggests that gut microbiota are associated with atherosclerosis (AS). However, the functional heterogeneity of each segment gives rise to regional differences in microbiota. We established a rat model AS by feeding rats high-fat diet for long period. The pathological and changes ileum colon were examined, correlations between analyzed. aortic mesothelium experimental was damaged. intima showed evident calcium salt deposition, indicating successfully developed. noted varying...
Usnea diff ;racta Vain. (U. diffracta) belonging to the genus, is widely used as a folk medicine for treatment of ulcer, abdominal pain, diarrhea, malaria and so on. However, antiatherogenic effect U. diffracta has not yet been reported. This study aims investigate effects ethanol extract its mechanism.A high fat diet VD3 were establish atherosclerotic rat model, with 0.004 g/kg/d simvastatin positive control, fed 0.7, 1.4, 2.8 21 days. The blood, liver, aorta samples from each collected...
Abstract Background: Alzheimer's disease (AD) is the most common cause of dementia. Traditional Chinese formula Danggui Shaoyao San (DSS) has been considered a potential therapeutic approach for AD. However, no systemic review regarding its efficacy and safety conducted. Herein, we propose protocol study that aims to evaluate DSS in patients with Methods: Sixteen electronic databases including PubMed, EMBASE, Cochrane database, Web science, National Knowledge Infrastructure, VIP, Wanfang...
To observe the apoptosis-related genes expression in difference groups and action of Valeriana jatamansi Jones. EPM was used to make anxiety model rat. The gene chart normal rats, rats treated by extract Jones were examined using chip technology. Compared with group, Elk-1, Ets-1, Apaf-1, Bax Bcl-2 up-regulated group. But abnormal adjusted other groups. can play a important role regulating
This study aimed to decode the potential bioactive compounds and action mechanism of Hippophae rhamnoides in treating Sjögren’s syndrome using network pharmacology molecular docking approach. The Traditional Chinese Medicine Systematic Pharmacology Database Analysis Platform (TCMSP) HERB (a High--throughput Experiment- Reference-guided database TCM) were used identify active components -Hippophae their targets. Databases, including GeneCards, Online Mendelian Inheritance (OMIM), DisGeNET,...