A5101525847- Gut microbiota and health
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Cellular transport and secretion
- Probiotics and Fermented Foods
- Meat and Animal Product Quality
- Helicobacter pylori-related gastroenterology studies
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolites in Food Biotechnology
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Natural product bioactivities and synthesis
- Food composition and properties
- Polysaccharides and Plant Cell Walls
- Fungal and yeast genetics research
- Metabolomics and Mass Spectrometry Studies
- Microbial Inactivation Methods
- Sirtuins and Resveratrol in Medicine
- Protein Hydrolysis and Bioactive Peptides
- 14-3-3 protein interactions
- Calcium signaling and nucleotide metabolism
- Nuts composition and effects
- Sensory Analysis and Statistical Methods
- Trace Elements in Health
Institute of Food Science and Technology
2017-2025
Chinese Academy of Agricultural Sciences
2017-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Institute of Agro-Products Processing Science and Technology
2017-2024
Lanzhou University
2009-2024
First Affiliated Hospital of Shihezi University Medical College
2008-2022
Chengdu University of Traditional Chinese Medicine
2022
Southwest Jiaotong University
2022
Sichuan University
2022
Shihezi University
2016
The pervasive use of antibiotics in agriculture and animal husbandry has raised a significant concern—residual antibiotic contamination food, which contributes to the natural evolution resistance pathogenic microbial strains. emergence communities poses global threat food safety security. Recently, situation been exacerbated by discovery novel strains resistant bacteria (ARB) plant- animal-derived foods. These microbes can enter human body through direct contact with affected animals or...
The ADP-ribosylation factors (Arfs) are six proteins within the larger Arf family and Ras superfamily that regulate membrane traffic. Arfs all share numerous biochemical activities have very similar specific activities. use of dominant mutants brefeldin A has been important to discovery cellular functions but lack specificity between isoforms. We developed small interference RNA constructs capable depletion each cytoplasmic human examine in live cells. No single was required for any step...
In this study, we have used immunocytochemical and fractionation approaches to provide a description of the localization mammalian Cdc42 protein (designated Cdc42Hs) in vivo. A specific anti-peptide antibody was generated against C-terminal region Cdc42Hs. Using affinity-purified preparations indirect immunofluorescence experiments, Cdc42Hs found be localized Golgi apparatus. Similar well-characterized non-clathrin coat proteins ADP-ribosylation factor (ARF) beta-COP, perinuclear clustering...
Inflammatory Bowel Disease (IBD) is an autoimmune disease, and the gut microbiota has become a new therapeutic target. Herbal medicine (HM) shown good efficacy in clinical treatment of IBD; however, synergistic actions dominant chemicals HM decoctions are unclear.In this study, we explored whether complicated interconnections between could allow crosstalk ingredients. Saponins polysaccharides, i.e., Codonopsis pilosula Nannf (CPN) decoction, were investigated dextran sulfate sodium- (DSS-)...
Fermentation represents an efficient biotechnological approach to increase the nutritional and functional potential of traditional Chinese medicine. In this study, Lactobacillus plantarum was used ferment medicine Astragalus, differential metabolites in fermented Astragalus (FA) were identified by ultra-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap mass spectrometry (UPLC-Q-Exactive-MS), ameliorating effect FA on dextran sulfate sodium (DSS)-induced colitis mice...
Wild type and eight point mutants of Saccharomyces cerevisiae ARF1 were expressed in yeast bacteria to determine the roles specific residues vivo vitro activities. Mutations at either Gly2 or Asp26 resulted recessive loss function. It was concluded that N-myristoylation is required for Arf action cells but not nucleotide exchange cofactor activities vitro. (homologous Gly12 p21ras) essential binding activating nucleotide, guanosine 5′-3-O-(thio)triphosphate. This marked contrast results...
A cell-permeable peptide derived from an adaptor protein blocks cytokine receptor signaling and reduces inflammation.
Abstract This study examined the relationship between high‐fat, high‐sugar diet (HFHSD) and trinitrobenzene sulfonic acid (TNBS) induced mouse colitis, therapeutic effect of alpha‐linolenic (ALA) on HFHSD hyperlipidemia. We also possible underlying mechanisms behind their interactions. Female BABL/c mice were fed with for 9 weeks. At same time, ALA treatment (150 or 300 mg/kg) was administered a daily basis. end weeks, experimental colitis by intra‐colonic administration TNBS. Body weight,...
Probiotics are natural microbial agents with beneficial properties such as bacteriostatic and anti-infective properties. Lactobacillus plantarum Q21, Q25 QA85, were isolated from the Chinese specialty fermented food “Jiangshui” proved to be highly resistant Helicobacter pylori (p < 0.0001). In vitro results showed that QA85 strongly inhibited H. could specifically co-aggregate in (more than 56%). Strains have potential adhere cells hinder colonization To assess anti-H. efficacy of strains...
Abstract To examine the functions of Arf‐like protein, Arl1p, in Saccharomyces cerevisiae , a null allele, arl1 Δ ::HIS3 was constructed two strains. In one background only, loss ARL1 resulted temperature‐sensitive (ts) growth (suppressed on high‐osmolarity media). Allelic variation at SSD1 locus accounted for differences between Strains lacking exhibited several defects membrane traffic. First, strains secreted less protein as measured by TCA‐precipitable radioactivity found media [ 35 S...
Dysbiosis is a well-known factor in the pathogenesis of inflammatory bowel disease (IBD). However, discovery conserved microbiome association colitis largely unknown. The study’s goal was to look into core linked DSS-induced mice, which could aid development microbiome-based diagnostics and therapeutics. dextran sulfate sodium- (DSS-) induced acute model established mice controlled experimental setting, gut microbial community analysis from fecal samples carried out on Illumina MiSeq...
Abstract This research investigated the viscosity, thermal, thermomechanical, and microstructural properties of potato starch–wheat gluten composite systems with different starch/gluten ratios under mechanical shear heating conditions. Results showed that peak, trough, final viscosities increased increase in starch fraction. The breakdown setback values samples decreased increasing content, endothermic enthalpy a similar variation trend. gelatinization temperature significantly as proportion...
Lactiplantibacillus plantarum LZU-J-TSL6 with high γ-aminobutyric acid (GABA) production (3.838 g/L) was screened and isolated from the Chinese fermented food snack “Jiangshui”. The improvement effect on anxiety disorder explored using mice as animal models. In vitro results revealed that had potential to colonize intestine (p < 0.01) anxiety-like behavior of after seven days’ gavage significantly improved when compared model group. able effectively increase GABA content in hippocampus...
This study aimed to decipher the bioactive compounds and potential mechanism of traditional Chinese medicine (TCM) formula Fuzi Lizhong Decoction (FLD) for nonalcoholic fatty liver disease (NAFLD) treatment via an integrative network pharmacology approach.The candidate FLD its relative targets were obtained from TCMSP PharmMapper web server, intersection genes NAFLD discerned using OMIM, GeneCards, DisGeNET. Then, PPI component-target-pathway networks constructed. Moreover, GO enrichment...
Summary This study was designed to investigate the effects of Ca 2+ and Zn ions injection on post‐mortem tenderness caspase activation by examining expression caspase‐3 cytochrome c in beef skeletal muscles treated with . Results showed that accelerated tenderisation muscles, whereas retarded process. In ‐injected samples, level precursor decreased markedly without production activated caspase‐3, increased markedly. So, possibly promoted caspases upstream release, but inactivated activity...
Abstract A genetic screen for synthetic lethal interactions with arf1 − identified a recessive mutation in TRS130 , one of 10 components the trafficking protein particle (TRAPP) complex (Sacher et al. 2000 ). As is an essential gene, allele ( trs130‐101) novel that requires ARF1 viability. This was found to exhibit no defects secretory function, i.e. processing carboxypeptidase Y or invertase. YPT31 and YPT32 were subsequent as high‐copy suppressors trs130‐101 . Increasing gene dosage...
Extracts from five Tibetan medicinal plants collected the Plateau were evaluated for antiviral activity against herpes simplex virus type 2 (HSV-2) in vitro and vivo. Viral plaque reduction assays showed that extracts four out of inhibited HSV-2 infection significantly with 50% effective concentrations (EC50) values ranging 0.35 ± 0.11 to 1.83 0.21 mg/mL. The other plant, Swertia mussotii Franch. (Gentianaceae), exhibited inhibiting viral biosynthesis. In attachment assay, two plants,...