A5056969234- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Reproductive tract infections research
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- IL-33, ST2, and ILC Pathways
- Syphilis Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Genetic factors in colorectal cancer
- Parasites and Host Interactions
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Immune cells in cancer
- Colorectal Cancer Screening and Detection
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- Toxoplasma gondii Research Studies
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Genomic variations and chromosomal abnormalities
Guangzhou Medical University
2017-2025
Third Affiliated Hospital of Guangzhou Medical University
2019-2023
Qingzhou City People's Hospital
2021-2023
Shantou University
2017-2018
Shantou University Medical College
2018
Yue Bei People's Hospital
2017-2018
The University of Texas MD Anderson Cancer Center
2017
Houston Methodist
2017
Cleveland Clinic Lerner College of Medicine
2011-2015
University of South China
2005-2015
Abstract IL-25 initiates, promotes, and augments Th2 immune responses. In this study, we report that Act1, a key component in IL-17-mediated signaling, is an essential signaling molecule for signaling. Although Act1-deficient mice showed reduced expression of KC (CXCL1) neutrophil recruitment to the airway compared with wild-type response IL-17 stimulation, Act1 deficiency abolished IL-25-induced IL-4, IL-5, IL-13, eotaxin-1 (CCL11), pulmonary eosinophilia. Using mouse model allergic...
Bladder cancer treatment remains a major clinical challenge due to therapy resistance and high recurrence rate. Profiling intratumor heterogeneity can reveal the molecular mechanism of bladder recurrence.Here, we performed single-cell RNA sequencing Assay for Transposase-Accessible Chromatin using (ATAC-seq) on tumors from 13 patients with low risk, recurrent cancer.Our study generated comprehensive cancer-cell atlas consisting 54,971 single cells identified distinct cell subpopulations. We...
Abstract Background The worldwide pandemic of COVID-19 remains a serious public health menace as the lack efficacious treatments. Cytokine storm syndrome (CSS) characterized with elevated inflammation and multi-organs failure is closely correlated bad outcome COVID-19. Hence, inhibit process CSS by controlling excessive considered one most promising ways for treatment. Results Here, we developed biomimetic nanocarrier based drug delivery system against via anti-inflammation antiviral...
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The next-generation sequencing (NGS) technology is currently widely utilized in clinical laboratories. This paper describes a method of technical improvement on NGS, which increases the success rates NGS detection. study reveals that DNA library concentration highest at molar ratio 100:1 for adapter to DNA. self-revised adaptor ligation can effectively improve rate library, particularly manual operations. Additionally, modified pooling method, incorporates various fragment sizes different...
Insulin resistance and associated metabolic health symptoms remain a primary global concern. In addition to healthy dietary nutritional programs, sleep duration is closely related has been linked metabolism. This study aimed determine the link between insulin intake of live microbes. Data were collected from 15,927 participants in National Health Nutrition Examination Survey database 2005 2018; this sample equivalent 209,316,590 individuals United States. The categorized according their...
A cell-permeable peptide derived from an adaptor protein blocks cytokine receptor signaling and reduces inflammation.
The cellular and molecular mechanisms driven by IL-25 its cognate receptor IL-17RB necessary for the promotion of Th2-mediating pathogenic pulmonary inflammation remains to be defined. We have previously reported critical role U-box-type E3 ubiquitin ligase Act1 (1) downstream signaling IL-17 cytokine family including Th2-promoting (IL-17E) (2). In this study, we report that IL-25-driven but not conventional IL-4-driven Th2 polarization production is impaired in Act1-deficient T cells. Also,...
Abstract IL-25 is a member of the IL-17 family cytokines that promotes Th2 cell–mediated inflammatory responses. signals through heterodimeric receptor (IL-25R) composed IL-17RA and IL-17RB, which recruits adaptor molecule Act1 for downstream signaling. Although role in potentiating type 2 inflammation well characterized by its ability to activate epithelium as T cells, components signaling cascade remain largely unknown. In this study, we found can directly STAT5 independently Act1....
Tumour vascular mimicry (VM) is the process by which new blood vessels are formed tumour cells rather than endothelial cells. An increasing number of studies have revealed that VM associated with cancer progression and metastasis. MiR-138-5p has been reported to act as a suppressor in many cancers. However, role underlying mechanism miR-138-5p hepatocellular carcinoma (HCC) remain unclear. In this study, density was detected CD31/periodic acid-Schiff double staining HCC clinical specimens....
The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum (T. pallidum) subsp. pallidum, the syphilis spirochete. well-recognized capacity of spirochete for early dissemination and immune evasion has earned it designation "the stealth pathogen." There are many hurdles to studying pathogenesis, most notably difficulty culturing genetically manipulating T. as well absence an effective vaccine prevention. infection humans is complex lengthy process. In...
Bone marrow-derived plasmacytoid dendritic cells (pDCs) from IL-1R-associated kinase (IRAK)2-deficient mice produced more IFNs than did wild-type pDCs upon stimulation with the TLR9 ligand CpG. Furthermore, in CpG-stimulated IRAK2-deficient there was increased nuclear translocation of IFN regulatory factor 7, key transcription for gene these cells. In macrophages, enhanced NF-κB activation and expression CpG-induced genes were detected within 2 h after treatment. However, at later times,...
Abstract Background This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China provide a reference basis for formulating prevention strategies HPV infection. Methods The present collected urethral epithelium or scraped penile epidermis from high-risk patients People's Hospital during last five years, extracted DNA fragments using boiling method, detected 23 types of genotypes by PCR-reverse...
Interleukin-1 receptor-associated kinase 2 (IRAK2) has been shown to be essential for lipopolysaccharide (LPS)-mediated posttranscriptional control of cytokine and chemokine production. In this study, we investigated the role IRAK2 activity in LPS-mediated by reconstituting IRAK2-deficient macrophages with either wild-type or kinase-inactive IRAK2. Compared (IRAK2-WT) macrophages, (IRAK2-KD) show reduced mRNA stability translation response LPS. Further, LPS-treated IRAK2-KD also activation...
Abstract Plasma cryopreservation is unavoidable in China, due to technical specifications requiring storage of additional plasma at −80 degrees for three years. However, the effect freezing on non-invasive prenatal testing (NIPT) still uncertain. We collected 144 euploid pregnant samples, 22 trisomy 21, 4 13, and 3 18, by massively parallel sequencing before after freezing. Compared with success rate 100% fresh detection rates 13 euploidy frozen samples NIPT were 95.45%, 75% 95.14%,...
Objective Genetic defects and endocrine-related factors are the leading causes of male infertility. This study was performed to analyze genetic characteristics sex hormone levels in different types Methods A total 423 men with infertility underwent analysis at The Sixth Affiliated Hospital Guangzhou Medical University. Results incidences abnormal karyotypes patients infertility, azoospermia, oligoasthenozoospermia were 6.94%, 22.40%, 15.09%, respectively. Among Klinefelter syndrome (47,XXY)...