A5101566097- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Biochemical and Molecular Research
- Cancer Immunotherapy and Biomarkers
- Minimally Invasive Surgical Techniques
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- Spine and Intervertebral Disc Pathology
- Pancreatic and Hepatic Oncology Research
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Urological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Shoulder Injury and Treatment
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Acupuncture Treatment Research Studies
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Abdominal Trauma and Injuries
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Sun Yat-sen University
2019-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2021-2024
Second Hospital of Tangshan
2022-2024
Tengzhou Central People's Hospital
2023
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Shantou University
2021
First Affiliated Hospital of Shantou University Medical College
2021
Peking University
2020
Background The Vesical Imaging-Reporting and Data System (VI-RADS) scoring system was created in 2018 to standardize imaging reporting of bladder cancer staging with multiparametric MRI. provides a five-point VI-RADS score, which suggests the likelihood detrusor muscle invasion. Muscle-invasive disease carries worse prognosis requires radical surgery. Purpose To determine performance score detecting muscle-invasive cohort patients undergoing MRI before Materials Methods In this retrospective...
Bladder cancer treatment remains a major clinical challenge due to therapy resistance and high recurrence rate. Profiling intratumor heterogeneity can reveal the molecular mechanism of bladder recurrence.Here, we performed single-cell RNA sequencing Assay for Transposase-Accessible Chromatin using (ATAC-seq) on tumors from 13 patients with low risk, recurrent cancer.Our study generated comprehensive cancer-cell atlas consisting 54,971 single cells identified distinct cell subpopulations. We...
There were few articles reviewed prognostic factors of surgical site infection (SSI) in patients with spinal metastases following surgery. The purpose the present study was to systematically: (1) investigate incidence rates SSI surgery; (2) identify which independently associated postoperative wound infection. One hundred sixty-seven consecutive adult and underwent treatment retrospectively enrolled from January 2011 February 2022. Demographic data, disease operation-related indicators...
Sunitinib is a first-line targeted therapy for patients with renal cell carcinoma (RCC), but resistance represents significant obstacle to the treatment of advanced and metastatic RCC. Metabolic reprogramming characteristic RCC, changes in metabolic processes might contribute sunitinib. Here, we identified MTHFD2, mitochondrial enzyme involved one-carbon metabolism, as critical mediator sunitinib MTHFD2 was elevated resistant RCC cells, loss MTHDF2 conferred sensitivity In patients, highly...
767 Background: Our study was established to evaluate the efficacy and safety of IAC combined with tislelizumab BCG as a bladder-preserving treatment for HR NMIBC pts. Methods: This open-label, single arm phase II enrolled BCG-naïve pts papillary tumors (high-grade Ta or T1 tumors). Firstly, should be removed all visible lesions by TURBT. Secondly, angiographic catheter placed into internal iliac arteries Seldinger’s percutaneous technique, cisplatin (60 mg/m 2 ) epirubicin (50 were...
<p>Figure S1-S17,Table S1-S2,Supplementary methods</p>
<div>Abstract<p>Sunitinib is a first-line targeted therapy for patients with renal cell carcinoma (RCC), but resistance represents significant obstacle to the treatment of advanced and metastatic RCC. Metabolic reprogramming characteristic RCC, changes in metabolic processes might contribute sunitinib. In this study, we identified methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), mitochondrial enzyme involved one-carbon metabolism, as critical mediator sunitinib MTHFD2 was...
<p>Sunitinib resistant cell RNA_seq data</p>
<p>MTHFD2_KD cell RNA_seq data</p>
Plant sterols (PS) have potential preventive function in atherosclerosis due to their cholesterol-lowering ability. Dietary α -linolenic acid flaxseed oil is associated with a reduction cardiovascular events through its hypolipidemic and anti-inflammation properties. This study was designed evaluate the effects of containing ester PS (ALA-PS) on investigate underlying mechanisms. C57BL/6 mice were administered regular diet apoE knockout (apoE-KO) given high fat alone or supplemented 5%...
Purpose Surgical removal of pheochromocytoma (PCC), including open, laparoscopic, and robot-assisted adrenalectomy, is the cornerstone therapy, which associated with high risk intraoperative postoperative life-threatening complications due to hemodynamic instability (IHD). This study aims develop validate a nomogram based on clinical characteristics as well computed tomography (CT) features for prediction IHD in surgery. Methods The data from 112 patients were collected at single center...
618 Background: Previous studies have proved IAC could reduce the recurrence and progression of HR NMIBC. The KEYNOTE-057 study has supported benefits PD-1 inhibitor in NMIBC patients (pts). Our was established to evaluate efficacy safety combined with tislelizumab BCG as a bladder-preserving treatment for pts. Methods: This open-label, single arm phase II enrolled BCG-naïve pts papillary tumors (high-grade Ta or T1 tumors). Firstly, should be removed all visible lesions by transurethral...
The recurrence of prostate cancer (PCa) is intrinsically linked to increased mortality. goal this study was develop an efficient and reliable prognosis prediction signature for PCa patients. training cohort acquired from Cancer Genome Atlas (TCGA) dataset, while the validation obtained Gene Expression Omnibus (GEO) dataset (GSE70769). To explore Gleason score (GS)-based signature, we screened differentially expressed genes (DEGs) between low- high-GS groups, then univariate Cox regression...
Background: Lymph node metastasis (LNM) is an important pathological characteristic of bladder cancer (BCa). However, the molecular mechanism underlying LNM was not thoroughly elaborated. Identification for LNM-related biomarkers may contribute to making suitable therapies. So, current study aimed identify key genes and construct a prognostic signature. Methods: Based on Cancer Genome Atlas (TCGA) database, gene expression clinical information were obtained. Then, weighted co-expression...
Malignant pheochromocytoma with cerebral and skull metastasis is a very rare disease. Combining our case 16 previously reported cases identified from PubMed search, an analysis of 17 malignant was conducted. This literature review aimed to provide information on clinical manifestations, radiographic histopathological features, treatment strategies this condition.
Objective This study aimed to establish and internally verify the risk nomogram of postoperative acute kidney injury (AKI) in patients with renal cell carcinoma. Methods We retrospectively collected data from 559 carcinoma June 2016 May 2019 established a prediction model. Twenty-six clinical variables were examined by least absolute shrinkage selection operator regression analysis, related AKI determined. The model was multiple logistic analysis. Decision curve analysis conducted evaluate...
Objective: To compare the clinical effects of single-incision robot-assisted laparoscopic radical prostatectomy (RARP) with and without extraperitoneal special channel device. Methods: The data 70 patients who had undergone RARP in Robotic Minimally Invasive Surgery Center Sichuan Provincial People's Hospital from September 2020 to February 2021 were analyzed retrospectively, including 29 cases operated on device (group A) 41 B). All operations performed by retrograde bladder neck...