A5100708068- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Lipid metabolism and disorders
- Eosinophilic Esophagitis
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Medical Research and Treatments
- Mycobacterium research and diagnosis
- Dermatology and Skin Diseases
- Antimicrobial Peptides and Activities
- Ginseng Biological Effects and Applications
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ion Channels and Receptors
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Therapeutic Uses of Natural Elements
- Autoimmune and Inflammatory Disorders
Beijing University of Chinese Medicine
2015-2025
Tsinghua University
2014-2024
Hangzhou DAC Biotech (China)
2024
Lanzhou University
2024
Affiliated Hospital of North Sichuan Medical College
2024
Beijing Fengtai Hospital
2020-2021
Weatherford College
2020
Tang Hospital
2019
Chinese Preventive Medicine Association
2019
Peking University
2014
Abstract Preservatives are essential components in cosmetic products, but their safety issues have attracted widespread attention. There is an urgent need for safe and effective alternatives. Antimicrobial peptides (AMPs) part of the innate immune system potent antimicrobial properties. Using machine learning-assisted rational design, we obtained a novel antibacterial peptide, IK-16-1, with significant activity maintaining based on β-defensins. IK-16-1 has broad-spectrum properties against...
Ulcerative colitis is a gastrointestinal disorder intricately associated with intestinal dysbiosis, but effective treatments are currently limited. Indigo naturalis, traditional Chinese medicine derived from indigo plants, has been widely used in the treatment of ulcerative colitis. However, specific mechanisms have not yet identified. Accordingly, this study, we evaluated effects and naturalis on dextran sulfate sodium (DSS)-induced rats. Our results showed that potently alleviated...
Abstract Acute pancreatitis (AP) is one of the most common acute abdominal diseases. The digestive disease committee, Chinese Association Integrative Medicine, released Integrated traditional and Western medicine for diagnosis treatment in 2010. 1 Since then, further studies great progress have been made by domestic foreign counterparts from perspective both AP, including classification, fluid resuscitation, organ function maintenance, surgery intervention, enteral nutrition (EN), syndrome...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease, characterized by excessive accumulation of hepatocyte fat. However, there no exact and effective pharmacotherapy for NAFLD. Yinchen linggui zhugan decoction (YLZD) has been widely used to treat Nevertheless, its pharmacological molecular mechanisms have not clearly elucidated. This study was carried out investigate the active components YLZD explore potential treating NAFLD network pharmacology experimental verification....
Probiotics are natural microbial agents with beneficial properties such as bacteriostatic and anti-infective properties. Lactobacillus plantarum Q21, Q25 QA85, were isolated from the Chinese specialty fermented food “Jiangshui” proved to be highly resistant Helicobacter pylori (p < 0.0001). In vitro results showed that QA85 strongly inhibited H. could specifically co-aggregate in (more than 56%). Strains have potential adhere cells hinder colonization To assess anti-H. efficacy of strains...
Non-alcoholic fatty liver disease (NAFLD) is a prevalent disease, which features an abnormal accumulation of lipids inside hepatocytes. Steatohepatitis plays critical role in the process resulting fibrosis and cirrhosis. Curcumin puerarin are herbal products widely used Asia, believed to have therapeutic benefits for alleviating symptoms steatohepatitis. In this study, mice models steatohepatitis induced by methionine- choline-deficient diet (MCD) were established compare pharmacological...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent disease, with clinical spectrum ranging from simple to nonalcoholic steatohepatitis and cirrhosis. Puerarin, baicalin berberine are herbal products widely used in Asia, which believed possess therapeutic benefits for alleviating the symptoms of NAFLD. In present study, rat model NAFLD, induced by high-fat diet, was established orthographical experimentation investigate effects various combinations puerarin, on hepatic expression...
The physiological process of defecation is directly controlled by colorectal motility. transient receptor potential ankyrin 1 (TRPA1) channel expressed in small intestine enterochromaffin cells and involved gastrointestinal motility via serotonin release. In the colorectum, however, cell localization largely distinct from that intestine. Here, we investigated role lower tract TRPA1 modulating We found colonic tissue, predominantly mesenchymal lamina propria, which are clearly those These...
Gut microbiota play an important role in modulating energy contribution, metabolism, and inflammation, disruption of the microbiome population is closely associated with chronic metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD). Gegen Qinlian decoction (GGQLD), a well‐known traditional Chinese herbal medicine (CHM), was previously found to regulate lipid metabolism attenuate inflammation during NAFLD pathogenesis. However, underlying mechanism this process, well how gut...
Abstract Cartilage engineering that combines competent seeding cells and a compatible scaffold is increasingly gaining popularity potentially useful for the treatment of various bone cartilage diseases. Intensive efforts have been made by researchers to improve viability functionality engineered constructs are implanted into damaged cartilage. Here, we designed an integrative system combining gene controlled-release concept solve problems both cell through precisely regulating anti-apoptotic...
Anemia is one of the most common complications in patients with inflammatory bowel disease (IBD). Hepcidin as a key regulator iron metabolism pivotal mediating occurrence anemia chronic disease. Herein, we analyzed levels hepcidin sera from IBD by enzyme-linked immunosorbent assay and investigated its potential role regulating IBD. We observed that serum were increased active compared those remitted healthy controls was associated activity, CRP, ESR, respectively. Importantly, found...
Yinchen Linggui Zhugan decoction (YLZD) is an effective and classical traditional herbal prescription for treating the nonalcoholic fatty liver disease (NAFLD) has been proven to be in regulation of lipid metabolism disorder attenuate inflammation a NAFLD rat model. However, exact underlying mechanism not elucidated. In current study, model was established using high-fat diet (HFD) 10 weeks, followed by YLZD treatment with 1.92 g/kg/day 4 weeks explore mechanisms YLZD. Our results showed...
Yinchen Linggui Zhugan Decoction (YCLGZGD) is the combination of (LGZGD) and Yinchenhao (YCHD) decoctions, two famous traditional Chinese medicine prescriptions. In previous studies, we found that could regulate lipid metabolism disorder attenuate inflammation in pathological process nonalcoholic fatty liver disease (NAFLD). However, exact underlying mechanism remains unknown. The aim this study was to explore effect on experimental NAFLD its rats with high-fat diet (HFD) which established...
Background: Hudi enteric-coated capsule (HDC) is a Chinese medicine prescribed to treat ulcerative colitis (UC).However, its anti-inflammatory active ingredients and mechanisms remain unknown.This study aimed investigate the components of HDC explore potential against UC by integrating network pharmacology experimental verification.Methods: A DSS-induced murine model was established validate efficacy detecting disease activity index (DAI) histopathological changes.Network pharmacological...
Pulmonary fibrosis (PF) is a severe chronic lung disease with little effective treatment options other than transplantation. Adipose-derived mesenchymal stem cells (ADSCs) have been shown to exert therapeutic effects on PF, but the underlying mechanisms remain be further elucidated. Here, we show interaction of ADSCs and lung-originated at single-cell level, using bleomycin- (BLM-) induced mice PF model green fluorescent protein- (GFP-) labeled mouse ADSCs. The intratracheally injected were...
Mesenchymal stem cells (MSCs) show great promise in blood vessel restoration and vascularization enhancement many therapeutic situations. Typically, the co-implantation of MSCs with vascular endothelial (ECs) is effective for induction functional vivo, indicating its potential applications regenerative medicine. The effects MSCs-ECs-induced can be modeled vitro, providing simplified models understanding their underlying communication. In this article, a contact coculture model vitro an...
<b><i>Introduction:</i></b> Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsed eczema and serious pruritus. High-mobility group box 1 protein (HMGB1) nuclear-binding serves as an alarmin to promote responses. <b><i>Methods:</i></b> In this study, we established AD mouse model topical use of MC903 on ears then used specific HMGB1-binding peptide cIY8 HMGB1 inhibitor glycyrrhizin investigate fibroblast...
This paper is to explore the effect and mechanism of Gegenqinlian decoction on experimental nonalcoholic fatty liver disease (NAFLD) in vivo vitro. The final aim make clear whether would impact NAFLD through improving PPARγ suppress inflammation regulate lipid. data this research suggested that a potent way manage lipid inflammation.
Recent research suggests that although prokinetic agents, acid suppressors, and radical treatment for
ErChen and YinChen decoction (ECYCD) is an effective traditional Chinese medicine has been widely used in to treat nonalcoholic steatohepatitis (NASH), with good curative effects. However, the specific mechanisms underlying these effects are unclear. In this study, we determined efficacy of ECYCD a high‐fat diet‐induced NASH rat model, established by 8‐week administration diet. was administered daily for 4 weeks, after which rats were euthanized. The results demonstrated that ameliorated...