A5076969762- Inflammatory Bowel Disease
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Mycobacterium research and diagnosis
- Gastrointestinal motility and disorders
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Lipid metabolism and disorders
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Gastrointestinal disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- Phytochemistry and biological activity of medicinal plants
- Dietary Effects on Health
- Drug Transport and Resistance Mechanisms
- Cardiovascular Health and Disease Prevention
- Tissue Engineering and Regenerative Medicine
Beijing University of Chinese Medicine
2016-2025
Weatherford College
2024
Massachusetts General Hospital
2020-2023
Harvard University
2020-2023
Beijing Fengtai Hospital
2020
Ulcerative colitis is a gastrointestinal disorder intricately associated with intestinal dysbiosis, but effective treatments are currently limited. Indigo naturalis, traditional Chinese medicine derived from indigo plants, has been widely used in the treatment of ulcerative colitis. However, specific mechanisms have not yet identified. Accordingly, this study, we evaluated effects and naturalis on dextran sulfate sodium (DSS)-induced rats. Our results showed that potently alleviated...
Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role in homeostasis of the gastrointestinal tract. However, its mechanistic significance epithelial barrier elements remain unexplored. Here, our results revealed hyaluronan treatment resulted significant changes gut microbiota mice. To demonstrate functional consequences hyaluronan-treatment and hyaluronan-induced alterations, Citrobacter rodentium- DSS-induced colitis models transplantation approaches were...
The gut microbiota plays a critical role in the occurrence and development of IBS-D, however, IBS-D-associated tongue coating microbiome dysbiosis has not yet been clearly defined. To address this, we analyzed structure composition 23 IBS-D patients 12 healthy controls using 16S rRNA high-throughput sequencing analysis. results revealed that overall observed OTUs exhibited significant decrease compared with controls. Alpha diversity analysis showed community richness were significantly...
Inflammatory bowel disease (IBD) is a chronic recurrent IBD, whose cause involves the interaction between genetic and environmental factors. Although there recognized link immune response causal relationship circulating cell counts IBD remains controversial. This study aimed to elucidate genetically predicted IBD. We conducted bidirectional 2-sample Mendelian randomization (MR) using aggregated statistics from genome-wide association studies. The 5 leukocytes cells (monocytes, lymphocytes,...
Background & AimsEpidemiological and animal studies have indicated an inverse correlation between the rising prevalence of obesity metabolic syndrome exposure to helminths. Whether helminth-induced immune response contributes microbiota remodeling in remains unknown. The aim this study is explore immune-regulatory role helminth prevention HFD-induced through gut microbiome.MethodsC57BL/6J WT STAT6-/- mice were infected with Heligmosomoides polygyrus followed by high fat diet (HFD) feeding...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease, characterized by excessive accumulation of hepatocyte fat. However, there no exact and effective pharmacotherapy for NAFLD. Yinchen linggui zhugan decoction (YLZD) has been widely used to treat Nevertheless, its pharmacological molecular mechanisms have not clearly elucidated. This study was carried out investigate the active components YLZD explore potential treating NAFLD network pharmacology experimental verification....
The effects of indigo naturalis (IN), which is a traditional Chinese herbal formulation, have been clinically demonstrated in treating refractory ulcerative colitis (UC). present study aimed to verify the and mechanisms IN experimental UC rats. A total 48 male Sprague-Dawley rats were randomly divided into six groups: Chow, model, high-dose IN, medium-dose low-dose mesalazine (a bowel-specific aminosalicylate drug) groups. models administered 3.5% dextran sodium sulphate solution for 7 days....
Ulcerative colitis (UC) has seen a significant increase over the past 3 decades. However, our understanding of its etiology, pathogenesis, and pharmacological treatment remains limited. This comprehensive review aims to address these gaps by analyzing trends, evaluating previous research, providing insights for future investigations. We conducted bibliometric analysis UC-related papers indexed in Web Science from 1993 2022. The author, organization, country, keyword networks field UC were...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent disease, with clinical spectrum ranging from simple to nonalcoholic steatohepatitis and cirrhosis. Puerarin, baicalin berberine are herbal products widely used in Asia, which believed possess therapeutic benefits for alleviating the symptoms of NAFLD. In present study, rat model NAFLD, induced by high-fat diet, was established orthographical experimentation investigate effects various combinations puerarin, on hepatic expression...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by relapsing-remitting course owing to recurrent intestinal inflammation. UC often has symptoms such as intermittent rectal bleeding, diarrhea, and abdominal pain. As the precise etiology of not completely clarified, become public health challenge worldwide. According an epidemiological survey, there were about 350,000 new cases IBD in China from 2005 2014. By 2025, number patients will reach 1.5 million....
Inflammatory bowel disease (IBD), a group of multifactorial and inflammatory infirmities, is closely associated with dysregulation gut microbiota host metabolome, but effective treatments are currently limited. Qingchang Wenzhong Decoction (QCWZD) an classical traditional herbal prescription for the treatment IBD has been proved to attenuate intestinal inflammation in model acute colitis. However, role QCWZD recovery phase colitis unclear. Here, we demonstrated that mice treated showed...
Gut microbiota play an important role in modulating energy contribution, metabolism, and inflammation, disruption of the microbiome population is closely associated with chronic metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD). Gegen Qinlian decoction (GGQLD), a well‐known traditional Chinese herbal medicine (CHM), was previously found to regulate lipid metabolism attenuate inflammation during NAFLD pathogenesis. However, underlying mechanism this process, well how gut...
Qingchang Wenzhong Decoction (QCWZD) is a newly developed, effective traditional Chinese herbal formulation for ulcerative colitis (UC). In earlier studies, we found that QCWZD could relieve the clinical symptoms of UC patients, reduce inflammation, and improve intestinal barrier function in dextran sulphate sodium (DSS)-induced rats. However, relationship between gut microbiota was not clarified. this study, established rat model DSS-induced then investigated regulatory effects on using 16S...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation, which may develop into ulcerative colitis-associated carcinogenesis (UCAC) with progression. Qingchang Wenzhong Decoction (QCWZD) classic and effective prescription for the clinical treatment of UC. QCWZD has been shown to alleviate intestinal injury in acute UC models. This study aimed explore then verify pharmacological mechanisms UCAC therapy.In this study, approaches including...
The present study aimed to explore the mechanism of action Gegen Qinlian decoction (GGQLD) in experimental non‑alcoholic fatty liver disease (NAFLD). A total 30 rats were randomly divided into five groups: chow, model, high‑ and low‑dose GGQLD (GGQLD‑H GGQLD‑L, respectively) resveratrol (Resl) groups, treated with saline, Resl when a model high‑fat diet (HFD)‑induced NAFLD was established. Blood lipid enzymes detected following treatment for 8 weeks tissue pathology observed using Oil Red O...
Yinchen Linggui Zhugan decoction (YLZD) is an effective and classical traditional herbal prescription for treating the nonalcoholic fatty liver disease (NAFLD) has been proven to be in regulation of lipid metabolism disorder attenuate inflammation a NAFLD rat model. However, exact underlying mechanism not elucidated. In current study, model was established using high-fat diet (HFD) 10 weeks, followed by YLZD treatment with 1.92 g/kg/day 4 weeks explore mechanisms YLZD. Our results showed...
Yinchen Linggui Zhugan Decoction (YCLGZGD) is the combination of (LGZGD) and Yinchenhao (YCHD) decoctions, two famous traditional Chinese medicine prescriptions. In previous studies, we found that could regulate lipid metabolism disorder attenuate inflammation in pathological process nonalcoholic fatty liver disease (NAFLD). However, exact underlying mechanism remains unknown. The aim this study was to explore effect on experimental NAFLD its rats with high-fat diet (HFD) which established...
Ulcerative colitis (UC) is a chronic, nonspecific, inflammatory disease for which an effective treatment lacking. Our previous study found that Qingchang Wenzhong Decoction (QCWZD) can significantly improve the clinical symptoms of UC and ameliorate dextran sulphate sodium- (DSS-) induced ulcerative in rats by downregulating IP10/CXCR3 axis-mediated response. The purpose present was to further explore mechanism QCWZD models, were established 7-day administration 4.5% sodium solution....