A5101606976- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and biosynthesis
- Metabolism, Diabetes, and Cancer
- Tendon Structure and Treatment
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Tumors and Oncological Cases
- Respiratory Support and Mechanisms
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Air Quality and Health Impacts
- Algal biology and biofuel production
- Exercise and Physiological Responses
- Cancer-related gene regulation
- Cervical Cancer and HPV Research
- Immune cells in cancer
- Medical Imaging and Pathology Studies
- Climate Change and Health Impacts
- Head and Neck Cancer Studies
- Alcohol Consumption and Health Effects
Harvard University
2015-2023
Massachusetts General Hospital
2015-2023
Emory University
2023
Purdue University West Lafayette
2015-2022
E-Da Hospital
2012-2017
I-Shou University
2012-2013
National Taiwan University
2002
National Yang Ming Chiao Tung University
1998
Abstract An unbalanced increase in dietary omega-6 (n-6) polyunsaturated fatty acids (PUFA) and decrease omega-3 (n-3) PUFA the Western diet coincides with global rise chronic diseases. Whether n-6 n-3 oppositely contribute to development of disease remains controversial. By using transgenic mice capable synthesizing eliminate confounding factors diet, we show here that alteration tissue n-6/n-3 ratio leads correlated changes gut microbiome fecal serum metabolites. Transgenic able...
Abstract Background The purpose of this study was to investigate whether the pretreatment total and differential leukocyte counts can predict prognosis patients with oral cavity cancer. Methods In a retrospective analysis treated between 2004 2011, medical records 202 cancer were evaluated. Results Patients cancer, peripheral white blood cell (WBC) count, monocyte, neutrophil lymphocyte ratio increased advancement clinical stage. contrast, count decreased. Further, WBC, in those pathologic...
Abstract Epidemiological studies indicate an inverse correlation between the prevalence of so-called western diseases, such as obesity and metabolic syndrome, exposure to helminths. Obesity, a key risk factor for many chronic health problems, is rising globally accompanied by low-grade inflammation in adipose tissues. The precise mechanism which helminths modulate syndrome not fully understood. We infected high fat diet (HFD)-induced obese mice with intestinal nematode parasite...
Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role in homeostasis of the gastrointestinal tract. However, its mechanistic significance epithelial barrier elements remain unexplored. Here, our results revealed hyaluronan treatment resulted significant changes gut microbiota mice. To demonstrate functional consequences hyaluronan-treatment and hyaluronan-induced alterations, Citrobacter rodentium- DSS-induced colitis models transplantation approaches were...
Exposure to fine particulate matter, such as through air pollution, has been linked the increased incidence of chronic diseases. However, few measures have taken reduce health risks associated with particle exposure. The identification safe and effective methods protect against exposure-related damage is urgently needed. We used synthetic, non-toxic, fluorescent particles investigate physical distribution inhaled their effects on pulmonary systemic inflammation in mice. Tissue levels omega-3...
Ethanol (EtOH)-induced alterations in intestinal homeostasis lead to multi-system pathologies, including liver injury. ω-6 PUFAs exert pro-inflammatory activity, while ω-3 promote anti-inflammatory activity that is mediated, part, through specialized pro-resolving mediators [e.g., resolvin D1 (RvD1)]. We tested the hypothesis a decrease ω-6:ω-3 PUFA ratio would attenuate EtOH-mediated gut-liver axis. FA desaturase-1 (fat-1) mice, which endogenously increase levels, were protected against...
Abstract Aberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics fatty acid in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addressed. Here, by using vitro BCSC models, mammosphere-derived MCF-7 HMLE-Twist-ER cells, we found that with cell-like properties exhibited very distinct profile compared their parental characterized increased lipogenesis, especially activity stearoyl-CoA...
Abstract Melanoma has a high propensity to metastasize and exhibits poor response classical therapies. Dysregulation of the chemokine receptor gene CXCR4 is associated with melanoma progression, although n-3 polyunsaturated fatty acids (PUFAs) are known be beneficial for prevention, underlying mechanism this effect unclear. Here, we used acid desaturase (Fat-1) transgenic mouse model endogenous PUFA synthesis investigate influence elevated levels in metastatic melanoma. We found that...
Current Dietary Guidelines for Americans recommend replacing saturated fat (SFA) intake with polyunsaturated fatty acids (PUFAs) and monosaturated (MUFAs) but do not specify the type of PUFAs, which consist two functionally distinct classes: omega-6 (n-6) omega-3 (n-3) PUFAs. Given that modern Western diets are already rich in n-6 PUFAs risk chronic disease remains high today, we hypothesized increased n-3 rather than would be a beneficial intervention against obesity related liver diseases...
Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by severe systemic inflammation and rapid loss of muscle mass. Preventive therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect omega-3 (n-3) polyunsaturated fatty acid (PUFA) intervention on LPS-challenged mice with respect to inflammation, body weight expression Toll-like receptor 4 (TLR4) pathway components. LPS administration induced...
Hyperglycemia significantly contributes to the development and progression of metabolic diseases. Managing postprandial blood glucose fluctuations is particular importance for patients with hyperglycemia, but safe effective means reducing levels are still lacking. Five diets varying macronutrient ratios omega-3 fatty acid amounts were tested their glucose-lowering effects in male C57BL/6J mice. The potent further investigated underlying mechanisms beneficial on hyperglycemia models. Mice...
The role of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in the regulation energy homeostasis remains poorly understood. In this study, we used a transgenic fat-1 mouse model, which can produce n-3 PUFAs endogenously, to investigate how regulate morphology and function brown adipose tissue (BAT). We found that high-fat diet (HFD) induced remarkable morphological change BAT, characterized by “whitening” due large lipid droplet accumulation within BAT cells, associated with obesity...
Objectives Reducing the increased number of white adipocyte progenitors (WAP) is considered a novel approach to controlling obesity. The role omega‐3 polyunsaturated fatty acids (PUFA) in regulating WAP resident population unclear. objective this study was investigate effect PUFA on niche composition adipose‐derived stem cells. Methods Stromal vascular cell fraction (SVF) collected from subcutaneous fat wild‐type (WT) and transgenic mice carrying fat‐1 gene Caenorhabditis elegans (Fat‐1...
Scope: Sonchus Oleraceus , named bitter vegetable (BV), has been known to have multiple health benefits such as anti-aging and anti-inflammation. However, the role of BV in prevention obesity is unclear. The aim this study was examine effect lipid extracts (BVL) on development. Methods Results: Following treatments high fat diet-induced obese mice (C57BL/6J) with BVL (0.3 mg/g BW per mouse) for a month, exhibited significant reduction weight gain, blood triglyceride, fasting glucose compared...
Abstract The intestine interacts with many factors, including dietary components and ethanol (EtOH), which can impact intestinal health. Previous studies showed that different types of fats modulate EtOH-induced changes in the intestine; however, mechanisms underlying these effects are not completely understood. Here, we examined transcriptional responses to EtOH WT transgenic fat-1 mice (which endogenously convert n6 n3 polyunsaturated fatty acids [PUFAs]) identify novel genes pathways...
In recent years, orthodontic treatments have become increasingly popular. these treatments, forces, which cause the absorption and deposition of alveolar bone, are applied through brackets teeth in order to move expected position. The periodontal ligament (PDL) has a determinative role dental biomechanics; however, difficulty predicting PDL behavior limited advancement biomechanics. Therefore, this study intends measure biomechanical then develop an analytical model predict holistic...
Abstract Background: Melanoma is the most aggressive neoplasm due to its propensity metastasize and poor response classical therapies. Platelets are a critical factor for metastatic dissemination. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) known be able modulate platelet function have also been reported anti-cancer effects. Whether n-3 PUFAs preventive effect on melanoma metastasis by altering structure unclear. Methods: Fat-1 transgenic mice, which express an acid desaturase from...
The role of omega-3 polyunsaturated fatty acids (PUFA) in regulation energy homeostasis remains poorly understood. In this study, we aimed to investigate how PUFA regulate the morphology and function brown fat tissue (BAT) mice. Sixteen-week-old male wild type (WT) transgenic fat-1 mice, which are capable synthesizing PUFA, were fed a low-fat diet (LFD) or high-fat (HFD) for 13 weeks. Metabolic tissues, including BAT, white adipose liver, collected biochemical histological analysis....
Obesity is closely linked to the development of insulin resistance. This largely through overly activated lipolysis in adipose tissue for providing excess fatty acids peripheral tissues developing hyperglycemia. Adipose triglyceride lipase (ATGL)/desnutrin, catalyzes initial and rate‐limiting step hydrolysis release free circulation. Thus, inhibiting by lowering ATGL activity and/or expression has been proposed be a therapeutic approach improve glucose tolerance sensitivity obesity. The...