A5100626338- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Ovarian function and disorders
- Pelvic floor disorders treatments
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Maternal and Perinatal Health Interventions
- Cervical Cancer and HPV Research
- Estrogen and related hormone effects
- Pregnancy-related medical research
- Hernia repair and management
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Intraperitoneal and Appendiceal Malignancies
- Menopause: Health Impacts and Treatments
- Pregnancy and Medication Impact
- Gestational Trophoblastic Disease Studies
Taipei Veterans General Hospital
2016-2025
China Medical University Hospital
2016-2025
China Medical University
2016-2025
National Yang Ming Chiao Tung University
2016-2025
Institute of Geographic Sciences and Natural Resources Research
2024
Chinese Academy of Sciences
2024
Anhui Agricultural University
2023-2024
Hebei University of Technology
2021-2024
Daqing Oilfield General Hospital
2024
Southwest Jiaotong University
2024
In the Part I, we have discussed background of CA125 and development anti-CA125 monoclonal antibody (MAb) to highlight potential role MAb in management women with advanced stage epithelial ovarian cancer (EOC). Glycosylation change either by N-link or O-link is supposed play a modification immunity. Anti-CA125 MAb, which can be classified as OC 125-like Abs, M11-like OV197-like often used for diagnosing, screening, monitoring detecting mesothelin-related diseases abdominal cavity, particular...
The roles of the androgen receptor (AR) in female fertility and ovarian function remain largely unknown. Here we report on generation mice lacking AR ( –/– ) resulting influences reproductive system. Female appear normal but show longer estrous cycles reduced fertility. ovaries from sexually mature females exhibited a marked reduction number corpora lutea. After superovulation treatment, produced fewer oocytes also showed During periovulatory period, an intensive granulosa apoptosis event...
Adenomyosis is an oestrogen-dependent disease caused by a downward extension of the endometrium into uterine myometrium. Epithelial-mesenchymal transition (EMT) endows cells with migratory and invasive properties can be induced oestrogen. We hypothesized that oestrogen-induced EMT critical in pathogenesis adenomyosis. first investigated whether occurred adenomyotic lesions it correlated serum 17β-oestradiol (E2) levels. Immunohistochemistry was performed on corresponding eutopic samples from...
In Brief OBJECTIVE: To compare the immediate results of patients undergoing either two-channel single-port laparoscopic-assisted vaginal hysterectomy or conventional multiport hysterectomy. METHODS: Patients were randomly assigned to undergo using (n=50) approach. The outcome measures included blood loss, operative time, intraoperative and postoperative complications, time flatus passage after operation, pain (assessed by visual analog scale score analgesics use). RESULTS: general...
A significant decline in both incidence and prevalence of cervical cancers after widespread-introducing screening strategy by Papanicolau test (Pap test) has been found the world, but cancer is still one most common female cancers, reporting fourth also leading causes to result main women-associated morbidity mortality, particularly for those women living low- middle-income countries. Cervical important health concerns directly destroying global health-care system, partly because not only...
Objective To evaluate the efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms (VMS) associated with menopause in East Asian women. Methods In this phase 3, randomized, double-blind study, postmenopausal women VMS (minimum average frequency 10 days before randomization, ≥7/day or 50/week) received 30 mg/day placebo (weeks 1–12), followed by an open-label extension 13–24). The co-primary endpoints were mean changes daily severity at weeks 4 12. Results Among 301...
PURPOSE Lenvatinib plus pembrolizumab (len + pembro) significantly improved progression-free survival (PFS) and overall (OS) versus chemotherapy in previously treated advanced or recurrent endometrial cancer (aEC) the phase III Study 309/KEYNOTE-775. We report results from III, randomized, open-label European Network of Gynaecological Oncological Trial-en9/LEAP-001 study (ClinicalTrials.gov identifier: NCT03884101 ) that evaluated len pembro first-line aEC. METHODS Patients with stage to IV...
Using an ultra-mini-wound technique to dissect the adhesion surrounding umbilicus port site aiding laparoscopic staging surgery for treating a woman with early-stage endometrioid endometrial cancer (E-EC) who had widespread and extensive abdominal adhesions secondary previous complicated cesarean section (C/S) bladder rupture. A 70-year-old history of C/S complicating rupture treated Boari flap repair, leaving longitudinal depressed scar over abdomen from pubic hair area in her 30s was...