A5055351442- interferon and immune responses
- Inflammasome and immune disorders
- Oral microbiology and periodontitis research
- Tuberculosis Research and Epidemiology
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- Clostridium difficile and Clostridium perfringens research
- Extracellular vesicles in disease
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- dental development and anomalies
- Osteomyelitis and Bone Disorders Research
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Cardiac Ischemia and Reperfusion
- Gout, Hyperuricemia, Uric Acid
- Orthodontics and Dentofacial Orthopedics
- Immunotherapy and Immune Responses
- Periodontal Regeneration and Treatments
- Immune responses and vaccinations
- Immune Response and Inflammation
- Social and Behavioral Studies
- Quinazolinone synthesis and applications
Capital Medical University
2019-2025
Affiliated Hospital of Hebei University
2025
Hospital of Hebei Province
2025
Southwest Forestry University
2025
Beijing University of Chinese Medicine
2024
Nanchong Central Hospital
2023-2024
Hunan University
2023-2024
Beijing Anzhen Hospital
2019-2024
North Sichuan Medical University
2023-2024
Sanya City Women and Children Hospital
2024
Background: Myocardial ischemia-reperfusion (MI/R) injury is a significant clinical problem without effective therapy. Unbiased omics approaches may reveal key MI/R mediators to initiate injury. Methods: We used dynamic transcriptome analysis of mouse heart exposed various periods identify S100a8/a9 as an early mediator. Using loss/gain-of-function understand the role in injury, we explored mechanisms through and functional experiment. Dynamic serum levels were measured patients with acute...
Rationale: Thoracic aortic aneurysm (TAA) leads to substantial mortality worldwide. Familial and syndromic TAAs are highly correlated with genetics. However, the incidence of sporadic isolated TAA (iTAA) is much higher, genetic contribution not yet clear. Objective: Here, we examined characteristics iTAA. Methods Results: We performed a screen 551 iTAA cases 1071 controls via whole-exome sequencing. The prevalence pathogenic mutations in known causal genes was 5.08% cohort. selected 100...
Objective: To investigate the effect of LEARNS model in self-management patients with maintenance hemodialysis and volume overload. Methods: Eighty overload admitted from September 2022 to May 2024 were selected as main subjects this experiment. They divided into two groups based on odd or even days their admission, 40 each group. Patients included new group received education, while traditional education. The self-care ability, treatment adherence, quality life compared between Results:...
Promoting the efficiency of bone regeneration in loss diseases is a significant clinical challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter treatment times. However, recent years, extracellular vesicles (EVs) have gained attention due their exceptional osteogenic function superior effects compared traditional cell therapy. EVs emerged as promising therapy for tissue defect various physiological functions, such regulating immune response promoting...
Objective: To explore an intervention strategy for patients with fluid overload undergoing maintenance hemodialysis and to evaluate the effects of LEARNS model on improving self-care agency patient compliance. Methods: A total 76 at our hospital from March 2023 2024 were selected study. Patients randomly divided into two groups, 38 in each group. The control group received conventional interventions, while observation was treated using model. Self-care agency, compliance, quality life...
One novel C10 polyacetylene rhamnoside, 4,6,8-decatriyne-1-O-α-L-rhamnopyranoside, named xylariside A (1), together with two quinovopyranosides, 4,6,8-decatriyne-1-O-α-D-quinovopyranoside, B (2), and 8E-decaene-4,6-diyne-1-O-α-D-quinovopyranoside, C (3), were obtained from the solid fermentation of Xylaria sp. VDL4, an endophytic fungus isolated Vaccinium dunalianum wight (Ericaceae). Their chemical structures elucidated through a combination spectroscopic techniques. The antifungal...
The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key immune responses murine macrophages infected with M. bovis. Using ex vivo vitro approaches show the expression of was significantly increased during infection. Furthermore, suppressed interferon-β (IFN-β) production directly targeting TANK-binding kinase 1 (TBK1) mRNA both J774a.1...
Mycobacterium bovis, the causative agent of tuberculosis in cattle and humans, infects host macrophages induces endoplasmic reticulum stress (ERS), mitochondrial damage, interleukin (IL)-1β production. The relationship between these phenotypes is yet to be elucidated. In this study, we investigated role ERS damage IL-1β production during infection with a virulent M. bovis strain. We found that activates inflammasome via NOD-like receptor family, pyrin domain-containing 3 (NLRP3)-caspase-8...
Mycobacterium bovis (M. bovis) is the principal causative agent of bovine tuberculosis; however, it may also cause serious infection in human being. Type I IFN a key factor reducing viral multiplication and modulating host immune response against infection. However, regulatory pathways signaling during M. are not yet fully explored. Here, we investigate role pathogenesis mice.C57BL/6 mice were treated with IFNAR1-blocking antibody or Isotype control 24 h before After 21 84 days infection,...
Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, has been identified a serious threat to human population. It found that sodium butyrate (NaB), inhibitor histone deacetylase, can promote expression cathelicidin (LL37) and help body resist variety injuries. In current study, we investigate therapeutic effect NaB on regulation host defense mechanism against M. infection. We an increased LL37 in infected THP-1 cells after treatment. contrast, treatment significantly...
Abstract Background The purpose of present study was to identify the differentially expressed genes (DEGs) associated with BMP-9-induced osteogenic differentiation mesenchymal stem cells (MSCs) by using bioinformatics methods. Methods Gene expression profiles MSCs were compared between GFP-induced and MSCs. GSE48882 containing two groups gene profiles, 3 MSC samples from MSCs, downloaded Expression Omnibus (GEO) database. Then, DEGs clustered based on functions signaling pathways significant...
Mycobacterium bovis (M. bovis) is a member of the tuberculosis complex imposing high zoonotic threat to human health. The limited efficacy BCG (Bacillus Calmette–Guérin) and upsurges drug-resistant require new effective vaccination approaches anti-TB drugs. Poly (lactic-co-glycolic acid) (PLGA) preferential drug delivery system candidate. In this study, we formulated PLGA nanoparticles (NPs) encapsulating recombinant protein bovine neutrophil β-defensin-5 (B5), investigated its role in...
A novel and green adsorbent based on sulfobetaine-modified magnetic Fe3O4 nanoparticles (SBMNPs) was successfully synthesized via a convenient one-step chemical coprecipitation method applied to the removal of anionic dyes methyl blue (MB) amaranth (AM) from aqueous solution. The morphology properties SBMNPs were characterized using various methods, including Fourier-transform infrared spectroscopy, X-ray powder diffraction, transmission electron microscopy, vibrating-sample magnetometry....