A5100715684- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Ginseng Biological Effects and Applications
- Cannabis and Cannabinoid Research
- Plant Pathogens and Fungal Diseases
- Plant tissue culture and regeneration
- Bone fractures and treatments
- Inflammasome and immune disorders
- CRISPR and Genetic Engineering
- Protein Degradation and Inhibitors
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Toxoplasma gondii Research Studies
- Psoriasis: Treatment and Pathogenesis
- Natural product bioactivities and synthesis
- Dermatologic Treatments and Research
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
Soochow University
2025
Tianjin Third Central Hospital
2019-2025
Tianjin Medical University
2019-2025
Tianjin Fire Research Institute
2025
Tianjin International Joint Academy of Biomedicine
2025
China Institute of Veterinary Drug Control
2018-2024
Jilin Agricultural University
2023-2024
Jilin University
2024
First Hospital of Jilin University
2024
Xi'an Jiaotong University
2013-2023
Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert similar metabolic effects in different organs. Here, we establish model where autophagy plays roles insulin-producing β cells versus insulin-responsive cells, utilizing knockin (Becn1F121A) mice manifesting constitutively active autophagy. With high-fat-diet challenge, the autophagy-hyperactive unexpectedly show impaired glucose tolerance, but improved insulin sensitivity, compared with normal Autophagy...
Abstract Background In eukaryotes, miR-16 is an important microRNA (miRNA) that involved in numerous biological processes. However, it not fully understood how executes its physiological functions. the present study, we aimed to identify novel targets and study their Methods Candidate target genes of were screened by microarray analysis mRNA levels several cancer cell lines with enhanced miR-16. Three bioinformatics algorithms, including TargetScan, PicTar, miRanda, used combination...
Abstract Background The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inflammation and oxidative stress by regulating nuclear factor-E2-related factor (Nrf2), which mediates the expression anti-inflammatory- pro-survival-related genes vascular endothelium, thereby improving function. Methods Nrf2 knockout (Nrf2 KO) C57BL/6 background...
Abstract Background Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis gradually recognized as pivotal role in cardiovascular disease. However, little known about the regulatory of beclin1 control caspase-4 activation pyroptosis. The present study confirmed whether regulates mediated thereby protects Human Cardiac microvascular endothelial cells (HCMECs) against injury. Methods TTC Evan's blue dye, western blot,...
ABSTRACT Canine distemper virus (CDV) poses a severe threat to both domesticated and wild animals, including multiple carnivores. With the continued expansion of its host range, there is an urgent need for development safer more effective vaccine. In this study, we developed subunit vaccines based on bacterium-like particle (BLP) delivery platform containing BLPs-F BLPs-H, which display CDV F H glycoprotein antigens, respectively, using antigen-protein anchor fusions produced by recombinant...
Abstract Preeclampsia ( PE ), a pregnancy‐specific disorder, is leading cause of perinatal maternal‐fetal mortality and morbidity. Impaired cell migration invasion trophoblastic cells an imbalanced systemic maternal inflammatory response have been proposed as potential mechanisms pathogenesis. Comparative analysis between placentas normal profiled differentially expressed mi RNA s, lnc mRNA including miR‐19a‐3p (mi PSG 10P (lnc IL 1 RAP ). This study was conducted to investigate their roles...
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract. Photodynamic therapy (PDT) with a novel photosensitizer LD4 was used to treat UC rat models explore therapeutic effect mechanism LD4-PDT on UC. 16S ribosomal RNA detect composition Gut microbiota. Our findings indicate that could protect integrity colonic mucosa, alleviate response promote healing mucosa. Mechanism studies demonstrated inhibit NF-κB signaling pathway,...
Current research underscores the need to better understand pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). This study aimed identify key targets involved in progression of IPF. We employed Mendelian randomization (MR) with three genome-wide association studies four quantitative trait loci datasets driver genes Prioritized were evaluated respiratory insufficiency transplant-free survival. The therapeutic efficacy core gene was validated cellular animal...
We conducted a case–control study to investigate the role of three common IL-17A and IL-17F single nucleotide polymorphisms (SNPs) on susceptibility gastric cancer. A was using Chinese population 462 cancer subjects controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) taken genotype rs2275913, rs763780, rs3748067 within IL-17 gene. When comparing demographic characteristics between cases control groups, were more likely be cigarette smokers alcohol...
The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key immune responses murine macrophages infected with M. bovis. Using ex vivo vitro approaches show the expression of was significantly increased during infection. Furthermore, suppressed interferon-β (IFN-β) production directly targeting TANK-binding kinase 1 (TBK1) mRNA both J774a.1...
The aim of the present study was to explore effect microRNA (miR)‑153 on proliferation and migration pulmonary artery smooth muscle cells (PASMCs) in a hypoxic condition by targeting ρ‑associated, coiled‑coil‑containing protein kinase 1 (ROCK1) nuclear factor activated T cytoplasmic 3 (NFATc3). right ventricular systolic pressure, hypertrophy index, medial wall thickness area were studied at different time‑points after rats exposed hypoxia. Western blot analysis used detect ROCK1 NFATc3...
Abstract Background Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and related to loss dopaminergic neurons in substantia nigra. Several studies verified that microRNA (miRNAs) targeting Bim/Bax/caspase‐3 signaling axis involved apoptosis In this study, we aimed explore role miR‐221 PD. Methods To examine function vivo, used a well‐established 6‐OHDA‐induced PD mouse model. Then conducted adenovirus‐mediated overexpression mice. Results Our results...
Sepsis is a leading cause of morbidity and mortality in the intensive care unit, which caused by unregulated inflammatory response to organ injuries. Ulinastatin (UTI), an immunomodulatory agent, widely used clinical practice associated with improved outcomes sepsis. But its underlying mechanisms are largely unknown. Our study integrated bulk single cell RNA-seq data systematically explore potential effects UTI After adjusting for confounders negative binomial regression model, there were...
Mycobacterium bovis (M. bovis), the microorganism responsible for bovine tuberculosis (bTB), is transferred to people by ingestion of unpasteurized milk and unprocessed fermented products obtained from animals with infection. The identification M. in samples utmost importance successfully prevent zoonotic diseases maintain food safety. This study presents a comprehensive description highly efficient molecular test utilizing recombinase-aided amplification (RPA)–clustered regularly...