A5074430524- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Parasitic Diseases Research and Treatment
- Animal Virus Infections Studies
- Probiotics and Fermented Foods
- Gut microbiota and health
- Animal Disease Management and Epidemiology
- Coccidia and coccidiosis research
- Virus-based gene therapy research
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Immunotherapy and Immune Responses
- Virology and Viral Diseases
- Immune Response and Inflammation
- interferon and immune responses
- Animal Nutrition and Physiology
- Parasite Biology and Host Interactions
- Veterinary medicine and infectious diseases
- Antimicrobial Peptides and Activities
- Respiratory viral infections research
- Helminth infection and control
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Parasitic Infections and Diagnostics
Jilin Agricultural University
2016-2025
Liaoning Shihua University
2024
Huazhong University of Science and Technology
2024
Health Commission of Jilin Province
2023
Ministry of Education of the People's Republic of China
2023
Jilin Engineering Normal University
2020
Zhejiang Gongshang University
2016-2018
Jilin Agricultural Science and Technology University
2016
The First People's Hospital of Xiaoshan District, Hangzhou
2016
Wenzhou Medical University
2013
Eimeria spp. are responsible for chicken coccidiosis which is the most important enteric protozoan disease resulting in tremendous economic losses poultry industry. Understanding interaction between avian cecal microbiota and coccidia of interest development alternative treatments that do not rely on chemotherapeutics lead to drug resistance.We utilized 16S rRNA gene sequencing detect dynamics microbial community AA broilers challenged with tenella. Histopathological analysis cecum was also...
The type I interferon (IFN-I) signaling pathway is an important part of the innate immune response and plays a vital role in controlling eliminating pathogens. African swine fever virus (ASFV) encodes various proteins to evade host's natural immunity. However, molecular mechanism by which ASFV-encoded inhibit production remains poorly understood. In present study, ASFV MGF360-11L inhibited cGAS, STING, TBK1, IKKε, IRF7 IRF3-5D mediated activation IFN-β ISRE promoters, accompanied decreases...
African swine fever (ASF) is a devastating infectious disease of pigs caused by the virus (ASFV), which poses great danger to global pig industry. Many viral proteins can suppress with interferon signaling evade host's innate immune responses. Therefore, development an effective vaccine against ASFV has been dampened. Recent studies have suggested that L83L gene may be integrated into host genome, weakening system, but underlying mechanism unknown. Our study found negatively regulates...
Abstract Background The gut microbiota is a critical factor in the regulation of host health, but relationship between differential resistance hosts to pathogens and interaction microbes not yet clear. Herein, we investigated potential correlation piglets their disease using single-cell transcriptomics, 16S amplicon sequencing, metagenomics, untargeted metabolomics. Results Porcine epidemic diarrhea virus (PEDV) infection leads significant changes piglets. Notably, Landrace pigs lose quickly...
Hypertension is considered the most serious risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitory peptides (ACEIPs), which are made from tuna frame protein (TFP) and yellow fin sole (YFP), have been used previously to treat hypertension. However, production of these short usually dependent on enzymatic hydrolysis, resulting in a digested mixture that makes it difficult purify ACEIPs. Although has reported ACEIPs could be produced recombinant Escherichia coli...
Lactic acid bacteria (LAB) are the primary genera of intestinal flora and have many probiotic functions. In present study, Lactobacillus rhamnosus GG (LGG) ATCC 53103 was used to treat BALB/c mice. After LGG intervention, both low high doses were shown improve observed OTU, Chao1, ACE, Shannon indices, while Simpson index decreased, demonstrating that can promote microbiota abundance diversity. Furthermore, treatment increased abundances Firmicutes , Bacteroides Actinomycetes reducing...
Enterotoxigenic Escherichia coli (ETEC) is one of the major pathogens contributing to piglet diarrhea, with significant implications for both health and economic aspects livestock industry. SW207 an isolate Bacillus halotolerans isolated from cold- disease-resistant Leixiang pigs in Northeastern China. We have discovered that can survive pig's gastrointestinal fluid under conditions high bile salt concentration, displaying potent antagonistic activity against ETEC. In this study, we...
ABSTRACT Canine distemper virus (CDV) poses a severe threat to both domesticated and wild animals, including multiple carnivores. With the continued expansion of its host range, there is an urgent need for development safer more effective vaccine. In this study, we developed subunit vaccines based on bacterium-like particle (BLP) delivery platform containing BLPs-F BLPs-H, which display CDV F H glycoprotein antigens, respectively, using antigen-protein anchor fusions produced by recombinant...
Interferon (IFN)-λ plays an essential role in mucosal cells which exhibit strong antiviral activity. Lactobacillus plantarum (L. plantarum) has substantial application potential the food and medical industries because of its probiotic properties. Alphacoronaviruses, especially porcine epidemic diarrhea virus (PEDV) transmissible gastroenteritis (TGEV), cause high morbidity mortality piglets resulting economic loss. Co-infection by these two viruses is becoming increasingly frequent....
Avian coccidiosis posts a severe threat to poultry production. In addition commercial attenuated vaccines, other strategies combat are urgently needed. Lactobacillus plantarum has been frequently used for expression of foreign proteins as an oral vaccine delivery system using traditional erythromycin resistance gene (erm). However, antibiotic selection markers were often during protein and they pose risk transferring genes the environment, significantly restricting application in field...
ABSTRACT Newcastle disease virus (NDV) is a significant enveloped within the Paramyxoviridae family, posing major threat to global poultry industry. Increasing evidence suggests that cholesterol-25-hydroxylase (CH25H) and its enzymatic product, 25-hydroxycholesterol (25HC), exhibit broad-spectrum antiviral activity properties by modulating lipid metabolism various signaling pathways. However, specific role of CH25H in regulating NDV infection replication remains unclear. In this study, we...