A5105842019- Assisted Reproductive Technology and Twin Pregnancy
- Infrastructure Maintenance and Monitoring
- Microbial Community Ecology and Physiology
- Asphalt Pavement Performance Evaluation
- Neonatal Respiratory Health Research
- Healthcare Systems and Public Health
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Gynecological conditions and treatments
- Ectopic Pregnancy Diagnosis and Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive Health and Technologies
- Hepatitis B Virus Studies
- IL-33, ST2, and ILC Pathways
- Prenatal Screening and Diagnostics
- Wastewater Treatment and Nitrogen Removal
- Soil Carbon and Nitrogen Dynamics
- interferon and immune responses
- Pain Management and Placebo Effect
- Maternal and Perinatal Health Interventions
- NF-κB Signaling Pathways
- Wastewater Treatment and Reuse
- Chromium effects and bioremediation
- Genetics, Aging, and Longevity in Model Organisms
- Uterine Myomas and Treatments
Capital Medical University
2025
Shanghai Veterinary Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Tongji University
2024-2025
Capital University
2025
University of Southern California
2025
Obstetrics and Gynecology Hospital of Fudan University
2024
Kunming Tongren Hospital
2024
Agro-Environmental Protection Institute
2022-2024
Ministry of Agriculture and Rural Affairs
2018-2024
Farmed animals produce excrement containing excessive amounts of toxic heavy metals as a result consuming compound feed well receiving medical treatments, and the presence these may aggravate risk spreading drug-resistance genes through co-selection during manure treatment application processes. However, research on association between antimicrobial resistance is still lacking. In this study, metagenomic sequencing was used to explore effects environmentally resistome in manure. A relevance...
Abstract Background It has been reported that circadian clock components, Brain and Muscle ARNT-Like 1 (BMAL1) Circadian Locomotor Output Cycles Kaput (CLOCK), are essential for glioblastoma (GBM) stem cell (GSC) biology survival. Consequently, we developed a novel Cryptochrome (CRY) activator SHP1705, which inhibits BMAL1-CLOCK transcriptional activity. Methods We utilized GlioVis to determine genes differentially expressed in non-tumor versus GBM tissues. employed vitro vivo methods test...
Abstract Background Patients with non‐small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) experience worse clinical outcomes but respond better to immunotherapy than patients NSCLC without COPD. Mucosal‐associated invariant T (MAIT) cells, a versatile population of innate immune lymphocytes, have crucial function in the response infection tumors. This study investigated distribution MAIT cells COPD‐associated their involvement response. Methods Flow cytometry,...
<title>Abstract</title> The mortality rate and the number of deaths from ischemic heart disease (IHD) in developing regions have surpassed those developed regions. Since 1980, global IHD deaths, disability-adjusted life years (DALY), lost (YLL), lived with disability (YLD) significantly increased, particularly medium high Social Development Index (SDI). Although overall has declined, countries, especially SDI low-medium regions, are facing a greater burden death. In 1990s, while...
ABSTRACT Porcine epidemic diarrhea virus (PEDV), as a type of Alphacoronavirus causing acute and high death rate among sucking piglets, poses great financial damage to the swine industry. Nevertheless, molecular mechanism whereby PEDV enters host cells is unclear, limiting development PED vaccines anti-PEDV agents. The present study found that protein ribonuclease kappa (RNASEK) was regulated by USF2, transcription factor, facilitated replication. RNASEK identified novel binding partner...
<div class="section abstract"><div class="htmlview paragraph">The improvement of heat dissipation performance ventilated brake discs is vital to braking safety. Usually, the technical approaches shall be material optimization or structural improvement. In this paper, a simulation model transfer established using STAR-CCM+ software. Cast iron, aluminum metal matrix composite (Al-MMC), and carbon-ceramic materials (C-SiC) are compared. The results show that: Al-MMC has better...
Abstract The circadian clock has been associated with numerous diseases and, in recent years, linked to every known cancer hallmark. In the case of glioblastoma (GBM), high expression positive regulators clock, such as Brain and Muscle ARNT-Like 1 (BMAL1), shorter survival time while negative confers longer time. Furthermore, BMAL1 Circadian Locomotor Output Cycles Kaput (CLOCK) were found be essential for GBM stem cell (GSC) proliferation, stemness, metabolism. GSCs are typically resistant...
A nationwide survey of organic fertilizer was carried out in China, and 263 samples were collected to be analyzed for maturity indices (moisture content (MC), pH, electrical conductivity (EC), E4/E6, germination index (GI)) 7 heavy metals (Cu, Zn, Cd, Pb, Cr, As Ni). The MC, EC, E4/E6 GI showed large variations among the with ranges 6.9%-66.68%, 4.40-9.19, 0.76-13.38 mS/cm, 1.07-9.40, 10%-150%, respectively. concentrations As, Ni) also at 7.53-580.4, 0-2818, 0.02-149.3, 0 (not...
Eczema is a common chronic dermatological disease. Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term relief. Development of new treatment strategy that enables sustained and long-term maintenance on the skin surface necessary. A self-adhesive swelling microneedle patch (SDSMNs) was designed constructed using two-step casting method. The adhesive substrate prepared by blending gelatin dopamine via oxidation NaIO
Microbial community composition, function, and viability are important for biofilm-based sewage treatment technologies. Most studies of microbial communities mainly rely on the total deoxyribonucleic acid (DNA) extracted from biofilm. However, nucleotide materials released dead microorganisms may interfere with analysis viable their metabolic potential. In this study, we developed a protocol to assess as well composition function in biofilm system using propidium monoazide (PMA) coupled...
Fertilization mode affects soil quality and ecological health. The effects of four fertilization regimens on lignocellulose content, readily degradable carbohydrate decomposition, potential microbial functions in the topsoil a wheat–maize rotation system between 2012 2017 were investigated. control (control NFNB), high chemical fertilizer (HCF), biochar plus low (HBLCF), biochar-based (BBF) compared fundamental properties, structure, function degradation based metagenome analysis. diversity...
Abstract We analyzed the relationship between homocysteine concentration in blood and chronic obstructive pulmonary disease (COPD) related dyspnea by using data from National Health Nutrition Examination Survey (NHANES) database Mendel Randomization (MR), found that increase of cysteine will promote occurrence COPD dyspnea. What is known about ——this topic-sufficient sample size or Mendelian randomized analysis can well determine relevant causal relationship. Summarize impact this study——in...
ABSTRACT Background It has been reported that circadian clock components, Brain and Muscle ARNT-Like 1 (BMAL1) Circadian Locomotor Output Cycles Kaput (CLOCK), are uniquely essential for glioblastoma (GBM) stem cell (GSC) biology survival. Consequently, we developed a novel Cryptochrome (CRY) activator SHP1705, which inhibits BMAL1-CLOCK transcriptional activity. Methods We analyzed buffy coats isolated from Phase clinical trial subjects’ blood to assess any changes circadian, housekeeping,...
Anaplastic thyroid carcinoma (ATC) is a rare but the most aggressive type of carcinoma. Nevertheless, limited advances were made to reduce mortality and improve survival over last decades. Therefore, identifying novel diagnostic biomarkers therapeutic targets for ATC patients still needed. RNA sequencing data corresponding clinical features available from GEO TCGA databases. We integrated WGCNA PPI network analysis identify hub genes associated with development, RT-qPCR was employed...
<title>Abstract</title> <italic>Salmonella</italic> is a foodborne pathogen that causes disruption of intestinal mucosal immunity, leading to acute gastroenteritis in the host. In this study, it was discovered infection with <italic>Salmonella Typhimurium</italic> (<italic>STM</italic>) results significant decrease abundance <italic>Lacticaseibacillus</italic> intestines mice, while secretion IL-22 by ILC3 significantly increased. Feeding <italic>Lacticaseibacillus rhamnosus GG</italic>...