A5100687495- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- IL-33, ST2, and ILC Pathways
- Anesthesia and Sedative Agents
- Connective tissue disorders research
- Anesthesia and Pain Management
- Eosinophilic Esophagitis
- Cancer, Stress, Anesthesia, and Immune Response
- Sleep and Wakefulness Research
- Cardiac, Anesthesia and Surgical Outcomes
- Dermatology and Skin Diseases
- Cardiovascular Issues in Pregnancy
- Galectins and Cancer Biology
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Psoriasis: Treatment and Pathogenesis
- Optical Imaging and Spectroscopy Techniques
- Diet and metabolism studies
- Selenium in Biological Systems
- Phytoestrogen effects and research
- Metabolomics and Mass Spectrometry Studies
- Prostate Cancer Diagnosis and Treatment
First Affiliated Hospital of Jinan University
2019-2025
Beijing University of Chinese Medicine
2020-2025
Heilongjiang University of Chinese Medicine
2024
Jiangsu University
2020-2024
Affiliated Hospital of Jiangsu University
2020-2024
First Affiliated Hospital of Henan University
2023
Hunan Agricultural University
2018-2020
Beijing Electronic Science and Technology Institute
2020
Jinan University
2019
Abstract Recent studies have identified DNA replication stress as an important feature of advanced prostate cancer (PCa). The identification biomarkers for could therefore facilitate risk stratification and help inform treatment options PCa. Here, we designed a robust machine learning-based framework to comprehensively explore the impact on prognosis in 5 PCa bulk transcriptomic cohorts with total 905 patients. Bootstrap resampling-based univariate Cox regression Boruta algorithm were...
Intestinal microbiota dysbiosis and metabolic disruption are well-known as the primary triggers of ulcerative colitis (UC). However, their role in regulating group 3 innate lymphoid cells (ILC3s), which essential for intestinal health, remains unexplored during development disease severity. Here, our results showed that structure patients with severe UC (SUCs) differed from those mild (MiUCs), moderate (MoUCs), healthy controls (HCs). Microbes producing secondary bile acids (SBAs) SBAs...
Purpose: The provision of comfortable and safe environment for painless gastroscopy in obese patients is an urgent clinical problem. This study aimed to determine the efficacy safety novel Li anesthetic protocol obesity (LAPO) which included remifentanil-propofol regimen, manual right hypochondrial compression (MRHC), easy-to-create mask, jaw thrust at preoperative patients. Patients Methods: prospective, single-center, single-arm trial recruited 106 participants underwent LAPO gastroscopy....
Numerous studies have demonstrated a positive correlation between sleep disorders and hyperalgesia. These adversely affect the descending pain regulatory system. Researchers extensively studied midbrain dopamine system in relation to associated with disturbances. Our study shows that chronic deprivation decreases responses noxious stimuli within mouse nucleus accumbens, regulated by release intracellular signals. Furthermore, we confirmed D2 receptors play critical role deprivation....
Introduction Brain development involves several critical stages, such as proliferation, neuronal migration, axonal pathfinding, and connection formation. Sevoflurane, a γ -aminobutyric acid (GABA) receptor agonist, is widely used an inhaled general anesthetic. However, its impact on brain has raised increasing concerns, particularly regarding prenatal exposure. This study aims to investigate the effects of sevoflurane exposure (PSE) at different cortical focusing migration glutamatergic...
The clinical risks and prognosis of diabetic vascular intimal calcification (VIC) medial (VMC) are different. This study aims to investigate the mechanism VIC/VMC translocation. Anterior tibial arteries were collected from patients with foot amputation. then divided into VIC VMC groups. There plaques in all anterior arteries, while enrichment galectin-3 arterial group was significantly higher than that group. Furthermore, a macrophage/vascular smooth muscle cell (VSMC) coculture system...
Dachengqi Decoction (DCQD) as a classic traditional Chinese medicine has been reported to be effective in treating asthma, but its mechanism remains unknown. This study aimed reveal the mechanisms of DCQD on intestinal complications asthma mediated by group 2 innate lymphoid cells (ILC2) and microbiota. Ovalbumin (OVA) was used construct asthmatic murine models. IgE, cytokines (e.g., IL-4, IL-5), fecal water content, colonic length, histopathologic appearance, gut microbiota were evaluated...
Abstract Psoriasis is a common immune‐mediated inflammatory skin disease, caused by disturbed interactions between keratinocytes and immune cells. Chinese medicine shows potential clinical application for its treatment. Liquiritin flavone compound extracted from licorice antitussive, antioxidant antiinflammatory effects, therefore may have as psoriasis therapeutic. The aim of this work was to examine the possible roles that liquiritin in treating psoriasis. HaCaT cells were stimulated TNF‐α...
Prenatal exposure to anesthetics has raised increasing attention about the neuronal development in offspring. Animal models are usually used for investigation. As a new drug, esketamine is s-isoform of ketamine and twice as potent racemic with less reported adverse effects. Esketamine currently being become more favorable clinical anesthesia work, including surgeries during pregnancy, yet effect on offspring unknown. The present study aimed elucidate effects gestational administration...
Aims Diabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed explore mechanisms diabetic atherosclerosis. Methods ApoE −/− mice were fed with an high-fat diet and injected streptozotocin establish in vivo atherosclerotic model. RAW 264.7 cells treated oxidized low-density lipoprotein particles (ox-LDL) high glucose produce vitro Results In this study, we showed that diabetes promoted progression potentiates macrophage proinflammatory...
This study aimed to investigate patients' expectative pain of spinal anesthesia puncture and anxiety pre-anesthesia, examine the effect lidocaine-prilocaine cream remimazolam prior on relief release.
Myocardial dysfunction accompanied by severe sepsis could significantly increase the mortality rate of septic patients. This study investigated effects and potential mechanisms sevoflurane preconditioning on myocardial dysfunction, which was induced lipopolysaccharide (LPS; from Escherichia coli O55:B5; 18 mg/kg) in mice. Results indicated that 1 hour after administration, LPS a significant cell-surface Toll-like receptor 4 (TLR4), cytoplasmic IKKα protein expression, nuclear translocation...
Psoriasis is a chronic and multifactorial skin disease which caused by inflammatory infiltrates, keratinocyte hyperproliferation, accumulation of immune cells. As part the Aconitum species, Benzoylaconitine (BAC) shows potential antiviral, anti-tumor, anti-inflammatory effects. In this study, we investigated effects mechanisms BAC on tumor necrosis factor-alpha (TNF-α)/LPS-induced HaCaT keratinocytes in imiquimod(IMQ)-induced mice model. The results showed that could relieve symptoms...
In China, lamb and fish are well-known triggers for an asthma attack. Our investigation aims at assessing whether the long-term intake of meat or Basa would aggravate pulmonary inflammation as well exploring changes in intestinal microbiota immune cells asthmatic mice.The murine model was established by intraperitoneal injection ovalbumin (OVA) plus aluminum on day 0 14 nebulization OVA from 21 to 27. Lamb administered mice oral gavage 27.Our results showed that consumption increased number...
Dexmedetomidine, an α2-adrenergic receptor agonist, mitigates cognitive dysfunction in elderly patients after surgery with general anesthesia. However, the underlying mechanism by which dexmedetomidine reduces remains to be fully elucidated. The aim of this study was investigate effects on lipopolysaccharide (LPS)-induced neuronal cultured hippocampal neurons.LPS, presence and absence dexmedetomidine, applied neurons mimic post-surgical inflammation. Neuronal morphology, including neurite...
Although pediatric epidural analgesia is a well-established technique used perioperatively. It unclear whether lumbar or caudal suitable for osteogenesis imperfecta (OI) patients, which may be associated with brittle bones and spine deformity. We conducted retrospective study to investigate compare the efficacy of two continuous techniques in patients undergoing lower extremity osteotomy surgery using propensity score-matched analysis (PSMA).