A5100702820- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Healthcare and Venom Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Anesthesia and Sedative Agents
- Acupuncture Treatment Research Studies
- Respiratory Support and Mechanisms
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Morinda citrifolia extract uses
- Pain Management and Treatment
- Catalytic Processes in Materials Science
- Sleep and Wakefulness Research
- Nanomaterials for catalytic reactions
University of Hong Kong
2025
First People's Hospital of Foshan
2013-2025
Guangdong Medical College
2024
Jilin University
2023
Hunan University
2023
China University of Petroleum, East China
2023
Tunghai University
2022
Yantai University
2022
Nanjing Drum Tower Hospital
2022
Zhejiang University of Technology
2016-2017
Abstract In this study, a type of all‐degradable flame retardant wood/poly(lactic acid) (PLA) biocomposite (FPW) with low cost and excellent mechanical properties is prepared studied. A novel lignin‐based phosphorus‐containing (LMD) synthesized first. PLA, wood powder, poly(butyleneadipate‐ co ‐terephthalate), triglycidyl isocyanurate (TGIC), LMD are then melt‐blended to prepare FPW. The limiting oxygen index value PLAF25L15‐4T (25% L15MD 4% TGIC) reaches 28.6%. Furthermore, the residue at...
The development of efficient, stable, and visible-light-responsive photocatalysts is crucial to address the pollution water bodies by toxic heavy metal ions organic antibiotics. Herein, a series LaNi1-xFexO3/g-C3N4 heterojunction are prepared simple wet chemical method. Moreover, LaNi0.8Fe0.2O3/g-C3N4 composites characterized various methods, including structure, morphology, optical, electrochemical methods tetracycline degradation photocatalytic reduction Cr(VI) under visible light...
A novel copper-catalyzed cross-coupling reaction of sulfinamides and aryl boronic acids is developed. The highly chemoselective stereospecific, which allows mild synthesis optically pure sulfoximines with broad scope functional group tolerance. utility this method demonstrated by the asymmetric pharmaceutical intermediates.
Painful diabetic neuropathy (PDN) is a frequent and troublesome complication of diabetes, with little effective treatment. PDN characterized by specific spinal microglia-mediated neuroinflammation. Insulin-like growth factor 1 (IGF-1) primarily derives from microglia in the brain serves vital role averting microglial transition into proinflammatory M1 phenotype. Given that epigallocatechin-3-gallate (EGCG) potent anti-inflammatory agent can regulate IGF-1 signaling, we speculated EGCG...
Numerous studies have demonstrated a positive correlation between sleep disorders and hyperalgesia. These adversely affect the descending pain regulatory system. Researchers extensively studied midbrain dopamine system in relation to associated with disturbances. Our study shows that chronic deprivation decreases responses noxious stimuli within mouse nucleus accumbens, regulated by release intracellular signals. Furthermore, we confirmed D2 receptors play critical role deprivation....
Apelin is hypothesized to serve a dual function in pain processing. Spinal administration of apelin induces hyperalgesia, while opioid receptors are implicated the antinociceptive effects acute nociceptive models. However, whether apelin‑apelin receptor (APJ) system involved neuropathic remains be elucidated. The present study aimed evaluate impact and mechanism spinal apelin‑APJ pain. Chronic constriction injury (CCI) sciatic nerve produced sustained APJ upregulation, which was associated...
Neuropathic pain is a chronic condition with little specific treatment. Insulin-like growth factor 1 (IGF1), interacting its receptor, IGF1R, serves vital role in neuronal and brain functions such as autophagy neuroinflammation. Yet, the function of spinal IGF1/IGF1R neuropathic unclear. Here, we examined whether how IGF1 signaling affects pain-like behaviors mice constriction injury (CCI) sciatic nerve. To corroborate IGF1, injected intrathecally IGF1R inhibitor (nvp-aew541) or anti-IGF1...
Painful diabetic neuropathy (PDN) is among the common complications in diabetes mellitus (DM), with its underlying mechanisms largely unknown. Synapsin II primarily expressed spinal dorsal horn, and upregulation mediates a superfluous release of glutamate deficiency GABAergic interneuron synaptic transmission, which directly implicated facilitation pain signals hyperalgesic nociceptive response. Recently, synapsin has been revealed to be associated modulation neurite outgrowth, whereas...
Painful diabetic neuropathy is a common complication of diabetes mellitus with obscure underlying mechanisms. The adaptor protein APPL1 critical in mediating the insulin sensitizing and signaling. In neurons, reportedly affects synaptic plasticity, while its role pathogenesis painful masked. Our Western blotting revealed significantly decreased expression dorsal horn streptozocin-induced rats versus control rats, coupled concomitant mechanical thermal hyperalgesia. Afterward, determination...
Neurotoxicity of local anaesthetics has been alerted by more and peoples. Cav3.1 Cav3.2 T-type calcium channels were closely related with toxicity. However, the role Cav3.3, another subtype channel, on neurotoxicity induced remains unclear. CaMKIIγ is a kind multifunctional kinase associated variety physiological pathological process. channel CaMKIIγ. Up-regulation can increase currents at dorsal root ganglia (DRG). On contrary, down-regulation results in decrease. Is relation between Cav3.3...