A5000122387- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Neurological Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects of Natural Compounds
- Cardiac Ischemia and Reperfusion
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Vitamin C and Antioxidants Research
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Phytochemistry and Biological Activities
- Ginger and Zingiberaceae research
- Biological and pharmacological studies of plants
- Ferroptosis and cancer prognosis
- Phytochemical Studies and Bioactivities
- Synthesis and Biological Activity
Jinan University
2010-2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2010-2022
First Affiliated Hospital of Jinan University
2022
Jinan University
2022
University of Hong Kong
2012
Wannan Medical College
2007
Shanxi Provincial Children's Hospital
2007
National Natural Science Foundation of China
2007
Dana (United States)
2005
Cardiomyocyte apoptosis is an important event in doxorubicin (DOX)-induced cardiac injury. The aim of the present study was to investigate protection berberine (Ber) against DOX- triggered cardiomyocyte neonatal rat cardiomyocytes and rats. In cardiomyocytes, Ber attenuated DOX-induced cellular injury a dose-dependent manner. However, has no significant effect on viability MCF-7 breast cancer cells treated with DOX. reduced caspase-3 caspase-9, but not caspase-8 activity DOX-treated...
Microglia activation is one of the causative factors for neuroinflammation, which results in brain damage during neurodegenerative disease. Accumulating evidence has shown that flavonoid luteolin (Lut) possesses potent anti-inflammatory properties; however, its effect on microglia inhibition currently unknown. Moreover, it not clear whether Lut also indirect neuroprotective effects by reducing inflammatory mediators and suppressing activation. In this study, we examined lipopolysaccharide...
Acute lung injury is still a significant clinical problem having high mortality rate despite advances in antimicrobial therapy and supportive care made the past few years. Our previous study demonstrated that berberine (Ber) remarkably decreased attenuated mice challenged with LPS, but mechanism behind this remains unclear. Here, we report pretreatment Ber significantly reduced pulmonary edema, neutrophil infiltration, histopathological alterations; inhibited protein expression...
Myocardial dysfunction is a common complication in sepsis and significantly contributes to the mortality of patients with septic shock. Our previous study demonstrated that pretreatment berberine (Ber) protected against lethality induced by LPS, which was enhanced yohimbine, an [alpha]2-adrenergic receptor antagonist, Ber combined yohimbine also improved survival mice subjected cecal ligation puncture. However, no studies have examined whether reduce LPS-induced myocardial dysfunction. Here,...
Objectives: This study examined whether luteolin may exert an anti-inflammatory effect in microglia and be neuroprotective by regulating activation. Methods: We treated BV2 with 1·0 μg/ml lipopolysaccharide (LPS) after incubation for 1 hour, the nitric oxide (NO) levels were determined a Griess reaction, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) mRNA expression real-time PCR analysis, iNOS COX-2 protein...
Lipopolysaccharide (LPS) has been recognized as a major player in the pathogenesis of sepsis and neutralization LPS or inhibition its signal transduction mechanism is promising new treatment strategy preclinical experiments. However, these therapeutic approaches have shown unsuccessful clinical trials. activates Toll-like receptor 4 (TLR4) induces pro-inflammatory anti-inflammatory responses, altered innate adaptive immune responses eventually lead to immunosuppressive state. The future...
Sepsis remains a major cause of mortality in intensive care units, better therapies are urgently needed. Gram-negative bacterial lipopolysaccharide (LPS) is an important trigger sepsis. We have demonstrated that berberine (Ber) protects against lethality induced by LPS, which enhanced yohimbine (Y) pretreatment, and Ber combined with Y also improves survival septic mice. However, the precise mechanisms enhances protection LPS - remain unclear. The present study confirmed simultaneously...
Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced rats were treated BRL44408 (α2A-AR antagonist), prazosin (α1-AR antagonist) and/or reserpine. cardiomyopathy, indicated by reduced dP/dt cardiac troponin I phosphorylation, was attenuated BRL44408, this TNF-α...
Microglial activation plays an important role in neurodegenerative diseases associated with oxidative stress. tert-Butyl hydroperoxide (t-BHP), analog of hydroperoxide, mimics the damage to microglial cells. It has been reported that ginsenoside Rg1 (G-Rg1), active ingredient Panax ginseng, anti-stress and anti-inflammatory properties. The present study aims investigate ability G-Rg1 decrease t-BHP-mediated cell BV2 We performed flow cytometry assays facilitate detection reactive oxygen...
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) poses a serious threat to global public health and there is currently no effective antiviral therapy. It has been suggested that chloroquine (CQ) hydroxychloroquine (HCQ), which were primarily employed as prophylaxis treatment for malaria, could be used treat COVID-19. CQ HCQ may potential inhibitors SARS-CoV-2 entry into host cells, are mediated via...
Neural stem cells (NSCs) transplanted is one of the hottest research to treat Alzheimer’s disease (AD), but cholinergic neurons from were also susceptible cell death which Heat shock protein 70 (HSP70) was affirmed reverse. Related cognitive impairment, nervous should be investigated and ginsenoside Rg1 (G-Rg1) considered increase them. We chose tert-butyl hydroperoxide (t-BHP) damage model study in vitro. Functional properties our recombination plasmid pEGFP-C2-HSP70 by SH-SY5Y cells. To...
Myocardial dysfunction accompanied by severe sepsis could significantly increase the mortality rate of septic patients. This study investigated effects and potential mechanisms sevoflurane preconditioning on myocardial dysfunction, which was induced lipopolysaccharide (LPS; from Escherichia coli O55:B5; 18 mg/kg) in mice. Results indicated that 1 hour after administration, LPS a significant cell-surface Toll-like receptor 4 (TLR4), cytoplasmic IKKα protein expression, nuclear translocation...