A5077675113- Inflammatory Bowel Disease
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Immune cells in cancer
- Diet and metabolism studies
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Asthma and respiratory diseases
- Gastroesophageal reflux and treatments
Beijing University of Chinese Medicine
2018-2022
Beijing Fengtai Hospital
2020
Ulcerative colitis is a gastrointestinal disorder intricately associated with intestinal dysbiosis, but effective treatments are currently limited. Indigo naturalis, traditional Chinese medicine derived from indigo plants, has been widely used in the treatment of ulcerative colitis. However, specific mechanisms have not yet identified. Accordingly, this study, we evaluated effects and naturalis on dextran sulfate sodium (DSS)-induced rats. Our results showed that potently alleviated...
Abstract Background Ulcerative colitis (UC) is a kind of complex immune disease, the pathogenesis which remains elusive. Destruction intestinal barrier, extreme inflammation, oxidative stress, and apoptosis might play key roles in development UC. In previous studies, we observed that Qingchang Wenzhong granule (QCWZG) had exact effect on remission UC clinic; however, underlying mechanism has not been identified. This study aimed to reveal effects QCWZG physical barrier interactive network...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by relapsing-remitting course owing to recurrent intestinal inflammation. UC often has symptoms such as intermittent rectal bleeding, diarrhea, and abdominal pain. As the precise etiology of not completely clarified, become public health challenge worldwide. According an epidemiological survey, there were about 350,000 new cases IBD in China from 2005 2014. By 2025, number patients will reach 1.5 million....
Inflammatory bowel disease (IBD), a group of multifactorial and inflammatory infirmities, is closely associated with dysregulation gut microbiota host metabolome, but effective treatments are currently limited. Qingchang Wenzhong Decoction (QCWZD) an classical traditional herbal prescription for the treatment IBD has been proved to attenuate intestinal inflammation in model acute colitis. However, role QCWZD recovery phase colitis unclear. Here, we demonstrated that mice treated showed...
Gut microbiota play an important role in modulating energy contribution, metabolism, and inflammation, disruption of the microbiome population is closely associated with chronic metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD). Gegen Qinlian decoction (GGQLD), a well‐known traditional Chinese herbal medicine (CHM), was previously found to regulate lipid metabolism attenuate inflammation during NAFLD pathogenesis. However, underlying mechanism this process, well how gut...
Background: Hudi enteric-coated capsule (HDC) is a Chinese medicine prescribed to treat ulcerative colitis (UC).However, its anti-inflammatory active ingredients and mechanisms remain unknown.This study aimed investigate the components of HDC explore potential against UC by integrating network pharmacology experimental verification.Methods: A DSS-induced murine model was established validate efficacy detecting disease activity index (DAI) histopathological changes.Network pharmacological...
Background. An imbalance of macrophage M1/M2 polarization significantly influences the pathogenesis inflammatory bowel disease. Qingchang Wenzhong decoction (QCWZD) has a proven therapeutic effect on patients with disease (IBD) and can inhibit response in mice colitis. However, its macrophages during IBD treatment remains nebulous. Aim Study. Explore mechanism underlying QCWZD effects dextran sulfate sodium (DSS)-induced colitis mouse model vivo RAW264.7 cell vitro by observing dynamics....
Heweijiangni decoction (HWJND) is an effective traditional Chinese medicine prescription in clinical treatment of nonerosive reflux disease (NERD). Esophageal hypersensitivity and acid contribute to the disease. However, exact underlying mechanism action remains unclear. In this study, we observed effect HWJND on esophageal morphology a rat model ovalbumin (OVA)-induced visceral followed by exposure. was assessed measuring extent dilated intercellular spaces (DIS), desmosome disruption,...