A5053716886- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Ginseng Biological Effects and Applications
- Cholesterol and Lipid Metabolism
- Gastrointestinal motility and disorders
- Photoacoustic and Ultrasonic Imaging
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Tryptophan and brain disorders
- Ultrasound and Hyperthermia Applications
- Lipid metabolism and disorders
- Congenital gastrointestinal and neural anomalies
- Plant biochemistry and biosynthesis
- Asthma and respiratory diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Luminescence and Fluorescent Materials
- Phytochemistry and biological activity of medicinal plants
- Photodynamic Therapy Research Studies
Minzu University of China
2023-2025
Second Xiangya Hospital of Central South University
2018-2021
Central South University
2018-2021
Beijing University of Chinese Medicine
2019-2021
Beijing Fengtai Hospital
2020
Weatherford College
2020
Current nanodrug-based cancer therapy is susceptible to the problems of rapid clearance from circulation and limited therapeutic efficacy. Herein, we report a magnetically targeted photothermal-triggered drug release nanotheranostics system based on superparamagnetic iron oxide (Fe3O4), IR780, doxorubicin (DOX), perfluoropentane (PFP) entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780/Fe3O4@PLGA/PFP/DOX NPs) for triple-modal imaging-guided synergistic breast cancer. In this...
Ulcerative colitis is a gastrointestinal disorder intricately associated with intestinal dysbiosis, but effective treatments are currently limited. Indigo naturalis, traditional Chinese medicine derived from indigo plants, has been widely used in the treatment of ulcerative colitis. However, specific mechanisms have not yet identified. Accordingly, this study, we evaluated effects and naturalis on dextran sulfate sodium (DSS)-induced rats. Our results showed that potently alleviated...
Background: Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance blood and inaccurate targeting. Materials Methods: Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise of drugs tumor sites enable a more efficient photothermal therapy (PTT) treatment. Results: Mimicking natural membrane, containing agents were not recognized cleared by immune system; they could circulate in for long time accumulate...
Although photothermal therapy (PTT) and photodynamics (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to limitations penetration depth hypoxic microenvironment tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment.In this work, mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed synergistic PDT/photothermal through image...
Combination photothermal therapy (PTT)/chemotherapy has become an emerging cancer treatment strategy in recent years.
Modulation of hypoxia is an essential factor for enhancing the effects antitumor therapies, especially sonodynamic therapy and chemotherapy. To improve efficacy combination by reversing hypoxic tumor microenvironment, we developed shell-core structured PPID-NPs, which were designed with a polymer shell onto sonosensitizer chemotherapeutic drug loaded perfluorocarbon core oxygen. The provides sufficient oxygen not only causing to produce more singlet induce cell apoptosis but also reducing...
The antipsychotic drug olanzapine was reported to induce nonalcoholic fatty liver disease (NAFLD), whereas the underlying mechanism remains incompletely understood. This study investigated whether apolipoprotein A5 (apoA5) and sortilin, two interactive factors involved in NAFLD pathogenesis, are implicated olanzapine-induced NAFLD. In our study, at week 8, treatment successfully induced hepatic steatosis female C57 BL/6 J mice, which independent of body weight gain. Likewise, effectively...
Although research on the treatment of atherosclerosis has progressed recently, challenges remain in developing more effective, safer and transformative strategies for atherosclerosis. Nanomaterials have recently played a unique role many fields, including treatment. Platelets are common component blood. Due to their inherent properties, platelets can target adhere atherosclerotic plaques. Ultrasound-targeted microbubble destruction (UTMD) shows great prospects promoting efficiency drug...
Qingchang Wenzhong Decoction (QCWZD) is a newly developed, effective traditional Chinese herbal formulation for ulcerative colitis (UC). In earlier studies, we found that QCWZD could relieve the clinical symptoms of UC patients, reduce inflammation, and improve intestinal barrier function in dextran sulphate sodium (DSS)-induced rats. However, relationship between gut microbiota was not clarified. this study, established rat model DSS-induced then investigated regulatory effects on using 16S...
Glucose metabolic disorders (GMD) can promote insulin resistance (IR) and diabetes, damage liver kidney.
Over the past several decades, nanocarriers have constituted a vital research area for accurate tumor therapy. Herein, magnetically targeted nanoparticles (IRFes) photothermal therapy were generated by integrating IR780, molecule with strong emission and absorption in NIR spectrum ability to produce heat after laser irradiation, Fe3O4 (NPs). These IRFes guided site application of an external magnetic field. In particular, IR780 was used NIRF imaging, we also demonstrated effective targeting...
Accurate diagnosis, providing guidance for early treatment, can greatly improve the survival rate of cancer patients. However, there are still some difficulties with existing diagnostic technology and treatment methods. Here, near-infrared responsive phase-shifted nanoparticles (NRPNs) have been designed magnetically targeted MR/US imaging photothermal therapy tumors. In this study, we fabricated a multifunctional polymer nanoparticle encapsulating indocyanine green (ICG), magnetic Fe3O4...
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by visceral hypersensitivity-related abdominal pain, in which diarrhea-predominant IBS (IBS-D) the main subtype and has high clinical incidence. Tongxie Anchang Decoction (TXACD) been proved to significantly improve pain patients with IBS-D, but its underlying therapeutic mechanism still remains unclear. In present study, IBS-D model rats were induced neonatal maternal separation (NMS) combined restraint...
This study aims to uncover the pharmacological mechanism of Tongxie Anchang Decoction (TXACD), a new and effective traditional Chinese medicine (TCM) prescription, for treating irritable bowel syndrome with diarrhea predominant (IBS-D) using network pharmacology.The active compounds putative targets TXACD were retrieved from TCMSP database published literature; related target genes IBS-D GeneCards; PPI common hub gene was constructed by STRING. Furthermore, these analyzed ontology (GO)...
Heweijiangni decoction (HWJND) is an effective traditional Chinese medicine prescription in clinical treatment of nonerosive reflux disease (NERD). Esophageal hypersensitivity and acid contribute to the disease. However, exact underlying mechanism action remains unclear. In this study, we observed effect HWJND on esophageal morphology a rat model ovalbumin (OVA)-induced visceral followed by exposure. was assessed measuring extent dilated intercellular spaces (DIS), desmosome disruption,...
Ginsenoside Rg3, Rk1, and Rg5, rare ginsenosides from Panax ginseng, have many pharmacological effects, which attracted extensive attention. They can be obtained through the heat treatment of Gynostemma pentaphyllum. In this study, scanning electron microscopy (SEM) thermal gravity-differential gravity (TG-DTG) were employed to investigate process content change in was analyzed using liquid chromatography-mass spectrometry (LC-MS). SEM TG-DTG used compare changes before after treatment. SEM,...
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a kind of functional gastrointestinal disorder with obscure pathogenesis, and exploration about differential gene expression cell heterogeneity T lymphocytes in peripheral blood IBS-D patients still remains unknown. Clinicians tend to use symptomatic treatment, but the efficacy unstable symptoms are prone relapse. Traditional Chinese Medicine (TCM) used frequently stable lower adverse effects. Tong-Xie-An-Chang Decoction (TXACD) has...
ABSTRACT The antipsychotic drug olanzapine was reported to induce nonalcoholic fatty liver disease (NAFLD), whereas the underlying mechanism remains incompletely understood. This study investigated whether apolipoprotein A5 (apoA5) and sortilin, two interactive factors involved in NAFLD pathogenesis, are implicated olanzapine-induced NAFLD. In present study, at week 8, treatment successfully induced hepatic steatosis male C57 BL/6J mice, even when fed a normal chow diet, which independent of...