A5103239027- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Diet, Metabolism, and Disease
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and biosynthesis
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Aldose Reductase and Taurine
- Pancreatic function and diabetes
- Connexins and lens biology
- Peroxisome Proliferator-Activated Receptors
- Dental Erosion and Treatment
- Diabetes Treatment and Management
- Ion Channels and Receptors
- Cardiovascular Effects of Exercise
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
Central South University
2021-2024
Second Xiangya Hospital of Central South University
2021-2024
The antipsychotic drug olanzapine was reported to induce nonalcoholic fatty liver disease (NAFLD), whereas the underlying mechanism remains incompletely understood. This study investigated whether apolipoprotein A5 (apoA5) and sortilin, two interactive factors involved in NAFLD pathogenesis, are implicated olanzapine-induced NAFLD. In our study, at week 8, treatment successfully induced hepatic steatosis female C57 BL/6 J mice, which independent of body weight gain. Likewise, effectively...
Abstract Studies have confirmed that olanzapine, the mainstay treatment for schizophrenia, triggers metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). However, etiology of olanzapine-induced NAFLD is poorly understood. Proprotein convertase subtilisin kexin type 9 (PCSK9) involved in pathogenesis, and metformin can significantly decrease circulating PCSK9. The purpose this study was to investigate role PCSK9 explore therapeutic effect olanzapine-associated NAFLD....
Background Bleaching is widely accepted for improving the appearance of discolored teeth; however, patient compliance affected by bleaching-related complications, especially bleaching sensitivity. This study aimed to investigate role reactive oxygen species (ROS) in cytotoxicity and pain conduction activated experimental tooth bleaching. Methods Dental pulp stem cells with or without N-acetyl-L-cysteine (NAC), an ROS scavenger, were cultured on dentin side enamel/dentin disc. Subsequently,...
Abstract Hyperalgesia has become a major problem restricting the clinical application of tooth bleaching. We hypothesized that transient receptor potential ankyrin 1 (TRPA1), pain conduction tunnel, plays role in hyperalgesia and inflammation after Dental pulp stem cells were seeded on dentin side disc, which was cut from premolar buccal tissue, with 15% (90 min) or 40% (3 × 15 bleaching gel applied enamel side, treated without TRPA1 inhibitor. The stimulated intracellular reactive oxygen...
Isolated right ventricular non-compaction (RVNC) is rare yet life-threatening if left untreated, especially when accompanied by tachycardia. We describe a case of isolated RVNC, presenting as prominent and excessive trabeculation the ventricle (RV), with an abnormal electrocardiogram. The transthoracic echocardiography, computed tomography, angiography results clearly demonstrated spongy RV, both anatomically functionally. Genetic testing identified missense mutation TTN . Combined,...
Long-term use of olanzapine, an antipsychotic drug, induces hypertriglyceridemia, resulting in a higher risk cardiovascular disease. However, the effects and underlying mechanisms short-term olanzapine on circulating triglyceride levels remain poorly understood. Here, role apolipoprotein A5 (apoA5), regulator metabolism, was investigated olanzapine-induced hypertriglyceridemia. Our multi-center clinical study recruited 36 schizophrenia patients who received (8 weeks) olanzapine. Besides,...
Abstract Schizophrenia, affecting approximately 1% of the global population, is often treated with olanzapine. Despite its efficacy, olanzapine's prolonged use has been associated an increased risk cardiovascular diseases and nonalcoholic fatty liver disease (NAFLD); however, underlying mechanism remains unclear. Proprotein convertase subtilisin kexin type 9 (PCSK9) plays a crucial role in lipid metabolism involved NAFLD pathogenesis via unknown mechanism. This study aims to investigate...
ABSTRACT The antipsychotic drug olanzapine was reported to induce nonalcoholic fatty liver disease (NAFLD), whereas the underlying mechanism remains incompletely understood. This study investigated whether apolipoprotein A5 (apoA5) and sortilin, two interactive factors involved in NAFLD pathogenesis, are implicated olanzapine-induced NAFLD. In present study, at week 8, treatment successfully induced hepatic steatosis male C57 BL/6J mice, even when fed a normal chow diet, which independent of...
Long-term treatment of olanzapine, the most widely-prescribed second-generation antipsychotic, remarkably increases risk non-alcoholic fatty liver disease (NAFLD), whereas mechanism for olanzapine-induced NAFLD remains unknown. Excessive hepatic fat accumulation is basis pathogenesis NAFLD, which results from disturbance TG metabolism in liver. Apolipoprotein A5 (ApoA5) a key regulator vivo that promotes hepatocytes, thereby resulting development NAFLD. However, there are no data indicating...
ABSTRACT Olanzapine, an antipsychotic drug, was reported to induce hypertriglyceridemia, whereas the underlying mechanism remains incompletely understood. This study determine role of apolipoprotein A5 (apoA5) in olanzapine-induced hypertriglyceridemia. In this study, 36 drug-naive and first-episode schizophrenic adult patients (aged 18–60 years) a multi-center clinical trial (ClinicalTrials.gov NCT03451734 ) were enrolled. Before after olanzapine treatment, plasma lipid apoA5 levels...
Abstract Background Long-term olanzapine treatment reportedly induces nonalcoholic fatty liver disease (NAFLD); however, the underlying mechanism remains unclear. Proprotein convertase subtilisin kexin type 9 (PCSK9) degrades low-density lipoprotein receptor (LDLR) and is involved in NAFLD pathogenesis via unknown mechanisms. Here, we investigated role of PCSK9 olanzapine-induced NAFLD. METHODS The mice model olanzapien drives was developed to investigate molecular terms hepatic cholesterol...