A5079064750- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Neurogenesis and neuroplasticity mechanisms
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and disorders
- Pelvic floor disorders treatments
- Gastrointestinal disorders and treatments
- Congenital gastrointestinal and neural anomalies
- Phytochemistry and biological activity of medicinal plants
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Nerve injury and regeneration
- Cancer Mechanisms and Therapy
- Respiratory and Cough-Related Research
- Medicinal Plants and Bioactive Compounds
- Dermatology and Skin Diseases
Beijing University of Chinese Medicine
2011-2025
Shenzhen Bao'an District People's Hospital
2024-2025
Beijing Fengtai Hospital
2014-2021
University Gastroenterology
2020
Weatherford College
2020
The gut microbiota plays a critical role in the occurrence and development of IBS-D, however, IBS-D-associated tongue coating microbiome dysbiosis has not yet been clearly defined. To address this, we analyzed structure composition 23 IBS-D patients 12 healthy controls using 16S rRNA high-throughput sequencing analysis. results revealed that overall observed OTUs exhibited significant decrease compared with controls. Alpha diversity analysis showed community richness were significantly...
Some Chinese herbs are anti-thrombolysis, and anti-inflammatory, improves brain RNA content, promotes protein synthesis, enhances dopamine function, regulates hormones, microcirculation in central nervous system that might improve, repair rehabilitation from the stroke injury. Specific their components, such as Acanthopanax, Angelica, could maintain survival of neural stem cells, Rhodiola, Ganoderma spore Polygala, Tetramethylpyrazine, Gardenia, Astragaloside Ginsenoside Rg1 promoted...
We aimed to investigate the effects of Panax notoginseng saponins (PNS) on proliferation, differentiation and self-renewal rat hippocampal neural stem cells (NSCs) in vitro. Rat NSCs were isolated from post-natal day 1 (P1) rats cultured a serum-free medium. The neurospheres identified by expressions nestin, class III β-tublin (Tuj-1) glial fibrillary acid protein (GFAP). given PNS subjected oxygen glucose deprivation (OGD) as an vitro model brain ischemia reperfusion. proliferation was...
Background We aimed to study the effect of Panax notoginseng saponins (PNS) on proliferation, differentiation, self-renewal, and expressions basic fibroblast growth factor (bFGF) brain-derived neurotrophic (BDNF) in rat embryonic neural stem cells (NSCs). Methods Cortical were isolated from embryos Embryonic Day 17 (E17) identified by nestin expression. Subsequently, primary culture, subculturing, single cell cloning performed cells. After first passage (P1), resuspended divided into a...
Hepatocellular carcinoma (HCC) is a highly invasive disease with high mortality rate. Our previous study found that Chenodeoxycholic acid (CDCA) as an endogenous metabolite can enhance the anti-tumor effect. Sorafenib has limited overall efficacy first-line agent in HCC, and combined CDCA may improve its efficacy.HepG2 cells Balb/c nude mice were used respectively for vitro vivo experiments. Flow cytometry, Western blotting, HE immunohistochemical staining immunofluorescence to effects of...
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by visceral hypersensitivity-related abdominal pain, in which diarrhea-predominant IBS (IBS-D) the main subtype and has high clinical incidence. Tongxie Anchang Decoction (TXACD) been proved to significantly improve pain patients with IBS-D, but its underlying therapeutic mechanism still remains unclear. In present study, IBS-D model rats were induced neonatal maternal separation (NMS) combined restraint...
This study aims to uncover the pharmacological mechanism of Tongxie Anchang Decoction (TXACD), a new and effective traditional Chinese medicine (TCM) prescription, for treating irritable bowel syndrome with diarrhea predominant (IBS-D) using network pharmacology.The active compounds putative targets TXACD were retrieved from TCMSP database published literature; related target genes IBS-D GeneCards; PPI common hub gene was constructed by STRING. Furthermore, these analyzed ontology (GO)...
Conventional approaches for patients with nonerosive gastroesophageal reflux disease (NERD) were not satisfactory. This study aimed to evaluate the effectiveness and mechanisms of Chinese herbal medicine Hewei Jiangni Decoction (HWJND) as a novel promising regimen NERD.A total 128 NERD randomly assigned Treatment group Control group. The from administered HWJND (81 g) plus dummy omeprazole (20 mg) daily 8 weeks, others given granules mg). clinical efficacy was assessed using questionnaire...
Heweijiangni decoction (HWJND) is an effective traditional Chinese medicine prescription in clinical treatment of nonerosive reflux disease (NERD). Esophageal hypersensitivity and acid contribute to the disease. However, exact underlying mechanism action remains unclear. In this study, we observed effect HWJND on esophageal morphology a rat model ovalbumin (OVA)-induced visceral followed by exposure. was assessed measuring extent dilated intercellular spaces (DIS), desmosome disruption,...
BACKGROUNDPrimary duodenal tuberculosis is very rare.Due to a lack of specificity for its presenting symptoms, it easily misdiagnosed clinically.Review the few case reports and literature on topic will help improve overall understanding this disease aid in differential diagnosis patient outcome. CASE SUMMARYA 71-year-old man with 30-plus year history bronchiectasis bronchitis presented Gastroenterology Department our hospital complaining intermittent upper abdominal pain.Initial imaging...
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a kind of functional gastrointestinal disorder with obscure pathogenesis, and exploration about differential gene expression cell heterogeneity T lymphocytes in peripheral blood IBS-D patients still remains unknown. Clinicians tend to use symptomatic treatment, but the efficacy unstable symptoms are prone relapse. Traditional Chinese Medicine (TCM) used frequently stable lower adverse effects. Tong-Xie-An-Chang Decoction (TXACD) has...
Abstract Background Proton pump inhibitor (PPI) is effective for the treatment of nonerosive gastroesophageal reflux (NERD), but long-term use PPI prone to have complications and recurrence after withdrawal. Traditional Chinese medicine (TCM) can relieve symptoms improve quality life. The purpose this study evaluate safety efficacy Hewei Jiangni recipe (HWJNR) in NERD with cold-heat complex syndrome, clarify mechanism HWJNR on based correlation analysis intestinal flora metabolites. Methods...
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory that lacks effective treatments. Qingchang Wenzhong Decoction (QCWZD) clinically herbal prescription has been proven to attenuate intestinal inflammation in IBD. However, its molecular mechanism of action not clearly elucidated.
Proton pump inhibitors, as the first-line drugs for treating gastroesophageal reflux disease (GERD), are unable to completely relieve patients' symptoms and patients prone recurrence after prolonged drug withdrawal. Thus, it is crucial find herbal medicines a complementary alternative treatment. Hewei Jiangni granule (HWJNG) classical Chinese medicinal formula with clinical therapeutic effects on GERD, but its pharmacological mechanism of action remains unclear. This study aimed explore then...
To uncover the underlying mechanism of Hewei Jiangni granule (HWJNG) on non-erosive reflux disease (NERD) treatment by examining histological changes, gastrointestinal neurochemicals release and visceral hypersensitivity-related receptor expression in NERD model rats. A rat was established via a combination basal sensitization acid perfusion. HWJNG treatments at different doses were then administered. Pathological changes to tissues, mast cell (MC) activation, serum levels esophageal...