A5057012556- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Reproductive Physiology in Livestock
- Hypothalamic control of reproductive hormones
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- RNA regulation and disease
- Stress Responses and Cortisol
- Amyotrophic Lateral Sclerosis Research
- Meat and Animal Product Quality
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Neurogenetic and Muscular Disorders Research
- Microbial Inactivation Methods
- Leech Biology and Applications
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Developmental Biology and Gene Regulation
- Potassium and Related Disorders
- Congenital gastrointestinal and neural anomalies
- Peroxisome Proliferator-Activated Receptors
Southern Medical University
2024-2025
Shanxi Agricultural University
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Nanjing University of Chinese Medicine
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2021
Xiyuan Hospital
2021
Chinese Academy of Agricultural Sciences
2020
China Agricultural University
2005-2019
Heilongjiang University
2019
The incidence of non-alcoholic fatty liver disease (NAFLD), commonly associated with obesity and metabolic syndrome, is increasing worldwide. However, the specific mechanisms that mediate progression from simple steatosis to steatohepatitis remain largely unclear. This study aimed investigate timedependent changes triglyceride (TG) free acid (FFA) levels in blood over 24 weeks high-fat diet-induced obese rats NAFLD clarify role high FFA injury. Male Wistar were randomly divided into three...
Autophagy is activated during nutritionally depleted or hypoxic conditions to facilitate cell survival. Because growth plate an avascular and tissue, autophagy may have a crucial role chondrogenesis; however, the functional underlying mechanism of in regulation remains elusive. In this study, we generated TamCart Atg7-/- (Atg7cKO) mice explore endochondral ossification. Atg7cKO exhibited retardation associated with reduced chondrocyte proliferation differentiation, increased apoptosis....
Numerous studies have demonstrated a robust correlation between metabolic syndrome (MetS) and colorectal cancer (CRC). Nonetheless, no systematic analysis or visualization of relevant publications has been conducted via bibliometrics. This research, centred on 616 obtainable through the Web Science Core Collection (WoSCC), employed CiteSpace software VOSviewer for analyses authors, journals, institutions, countries, keywords, citations. The findings indicate that Public Library had highest...
Androgens are known to modulate the skeletal muscle proliferation and differentiation processes. Recent in vitro studies have shown that dihydrotestosterone anabolic steroids functions promoting of mouse myoblast C2C12 cell line through classical androgen receptor (AR) signaling pathway. But there contradictory reports plays its roles membrane pathways. In present study, we show is no expression AR L6 cells both at gene protein levels. We then investigated effects testosterone (T) on...
The corticotropin-releasing hormone (CRH) signaling system is involved in numbers of stress-related physiological and pathological responses, including its inhibiting effects on estradiol (E2) synthesis follicular development the ovary. In addition, there are reports that microRNAs (miRNAs) can control function animal reproductive system. aim present study was to investigate functions miR-375 relationship between CRH molecules porcine First, our common PCR results show receptor 1 (CRHR1)...
Insulin resistance has been independently related to heart failure. However, the specific mechanisms of high FFA levels in pathophysiology failure insulin-resistant states are remain largely unclear. This study investigated whether elevated circulating free fatty acids (FFA) result impaired cardiac structure and function vivo via insulin-related signaling pathways myocardium. Male Wistar rats were randomly divided into intralipid group (20% plus heparin infusion) control (glycerol infusion)....
Abstract Black individuals are disproportionately burdened by prostate cancer compared to White individuals. The mitochondrion is an untapped source for (PCa) biomarkers, and previous work has shown altered mitochondrial DNA (mtDNA) copy number linked dysfunction tumorigenesis. We assess whether mtDNA in patients with without PCa a racially specific manner. Circulating cell-free from plasma white blood cells (WBCs) were measured 199 undergoing biopsy (50/50 cases/controls 50/49...
Fat deposition, which influences pork production, meat quality and growth efficiency, is an economically important trait in pigs. Numerous studies have demonstrated that stearoyl-CoA desaturase (SCD), a key enzyme catalyzes the conversion of saturated fatty acids into monounsaturated acids, associated with acid composition As SCD was observed to be significantly induced 3T3-L1 preadipocytes differentiation, we hypothesized it plays role porcine adipocyte differentiation fat deposition. In...
Objective. Tauroursodeoxycholic acid (TUDCA) has been considered an important regulator of energy metabolism in obesity. However, the mechanism underlying how TUDCA is involved insulin resistance not fully understood. We tested effects on autophagic dysfunction obese mice. Material and Methods. 500 mg/kg was injected into mice, metabolic parameters, autophagy markers, signaling molecular were assessed by Western blotting real-time PCR. Results. The injections mice resulted a reduced body...
Prostaglandin F 2 α (PGF ) is a key factor in the triggering of regression corpus luteum (CL). Furthermore, it has been reported that Slit/Robo signaling involved regulation luteolysis. However, interactions between PGF and progression luteolysis remain to be established. This study was designed determine whether regulated by mouse CL. Real-time PCR immunohistochemistry results showed Slit2 its receptor Robo1 are highly specifically co-expressed Functional studies participates enhancing cell...
Progranulin (PGRN), a multifunctional protein implicated in embryonic development and immune response, was recently introduced as novel marker of chronic inflammation related with insulin resistance obesity type 2 diabetes mellitus. However, the potential mechanisms PGRN on signaling pathways are poorly understood. In this study, mediated chemotaxis RAW264.7, impaired action stimulated production inflammatory factors adipocytes, which accompanied by increased c-Jun N-terminal kinase (JNK)...
Abstract RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation various cellar processes; however, its physiological roles adipocytes remain poorly characterized. Here, we report that adipocyte-specific knockout Rnf20 (ASKO) mice led to progressive fat loss, organomegaly and hyperinsulinemia. Despite signs hyperinsulinemia, normal insulin sensitivity improved glucose tolerance were observed young aged CD-fed ASKO mice....
Abstract The corpus luteum (CL) is a transient endocrine gland developed from the ovulated follicles, and most important function to synthesize secrete progesterone (P4), key hormone maintain normal pregnancy estrous cycle in mammals. It known that estrogen has vital role stimulating P4 synthesis CL, but it still remains unclear about mechanism of estradiol (E2) regulating production CL. Our results here first show all CL cells express MAPK 8 (MAP3K8), MAP3K8 level much higher at midstage...
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by visceral hypersensitivity-related abdominal pain, in which diarrhea-predominant IBS (IBS-D) the main subtype and has high clinical incidence. Tongxie Anchang Decoction (TXACD) been proved to significantly improve pain patients with IBS-D, but its underlying therapeutic mechanism still remains unclear. In present study, IBS-D model rats were induced neonatal maternal separation (NMS) combined restraint...
Corticotropin-releasing-factor (CRF) is a key regulator of catecholamines (CATs) biosynthesis in the adrenal gland. Furthermore, miR-375 has been confirmed to be localized mouse However, relationships between and CRF regulating CATs remain established. This study was designed investigate relationship regulation porcine Eight adult female pigs (four controls; four injected intracerebroventricularly with 50 μg CRF) were used for vivo experiments this study. The results showed that exclusively...