A5085093735- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Pharmacological Effects of Natural Compounds
- Smart Grid and Power Systems
- Ginseng Biological Effects and Applications
- High-Voltage Power Transmission Systems
- Traditional Chinese Medicine Analysis
- Power Systems and Technologies
- Advanced Sensor and Control Systems
- Healthcare and Venom Research
- Electric Motor Design and Analysis
- Plant-based Medicinal Research
- Power Systems and Renewable Energy
- Neuroinflammation and Neurodegeneration Mechanisms
- Osteoarthritis Treatment and Mechanisms
- HVDC Systems and Fault Protection
- Inflammatory mediators and NSAID effects
- Industrial Technology and Control Systems
- Family Caregiving in Mental Illness
- Advanced Algorithms and Applications
- Neurogenesis and neuroplasticity mechanisms
- Phytochemistry and Biological Activities
- Andrographolide Research and Applications
- Chemokine receptors and signaling
- Phytoestrogen effects and research
University of California, Los Angeles
2025
Beijing University of Chinese Medicine
2007-2023
Zhejiang University
2023
East China Normal University
2021-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Hexi University
2023
Linyi University
2018
Zhengzhou University
2006-2018
Shanghai Changning Mental Health Center
2012-2015
Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how regulate premetastatic niche tropism largely unknown. In this study, we report that osteoclast precursors (OPs) can function as a component facilitates breast cancer (BCa) metastasis at early stages. At the molecular level, unbiased GPCR ligand/agonist screening in BCa cells suggested R-spondin 2 (RSPO2) RANKL, through interaction with their receptor LGR4, promoted osteoclastic...
Abstract Inflammatory diseases decrease the extracellular environmental pH. However, whether proton-activated G protein-coupled receptors (GPCRs) can regulate development of osteoarthritis (OA) is largely unknown. In this study, we report that GPR4 essential for OA development. We found a marked increase in expression human and mouse cartilage. Lentivirus-mediated overexpression joints accelerated OA, including promotion articular cartilage damage, synovial hyperplasia, osteophyte formation,...
Hypomanic personality traits (HPT) are susceptibility markers for psychiatric disorders, particularly bipolar disorder, and strongly associated with aggressive behaviors. However, the neuropsychological mechanisms underlying this association remain unclear. This study utilized psychometric network analysis Inter-Subject Representation Similarity Analysis (IS-RSA) to explore circuits that link HPT aggression in a large non-clinical population. Psychometric (n = 716) identified two key nodes:...
Some Chinese herbs are anti-thrombolysis, and anti-inflammatory, improves brain RNA content, promotes protein synthesis, enhances dopamine function, regulates hormones, microcirculation in central nervous system that might improve, repair rehabilitation from the stroke injury. Specific their components, such as Acanthopanax, Angelica, could maintain survival of neural stem cells, Rhodiola, Ganoderma spore Polygala, Tetramethylpyrazine, Gardenia, Astragaloside Ginsenoside Rg1 promoted...
Ginsenoside Rb1, a major component of different ginseng species, can be bioconverted into compound K by gut microbiota, and the latter possess much stronger cancer chemopreventive potential. However, while initiation progression colorectal is closely associated with inflammation, to date, effects on inflammation-linked chemoprevention have not been reported. In present study, liquid chromatography quadrupole time-of-flight mass spectrometry analysis was applied evaluate biotransformation Rb1...
Andrographolide has a low aqueous solubility and oral bioavailability, which limits its clinical application. Reform the dosage forms of andrographolide to improve bioavailability. The formulation, characterisation, stability, anti-inflammatory effect, pharmacokinetics toxicity andrographolide-loaded microemulsion, were studied. An formulation O/W microemulsion consisting an oil phase isopropyl myristate, surfactant Tween 80, co-surfactant alcohol, water was found be ideal, with mean droplet...
The pHs of extracellular fluids (ECFs) in humans are consistently maintained at 7.35 to 7.45 physiological conditions.Pathological changes, including infarction, tumourigenesis and inflammation, commonly result decreases the ECF pH affected tissues.In this study, we report that proliferation is promoted apoptosis inhibited by pH.Furthermore, demonstrated proton-sensing G-protein-coupled receptors (GPCRs) required for pH-dependent regulation through G protein α subunit 12/13 (G12/13) Rho...
Osteoarthritis (OA) is one of the most common chronic diseases in world. However, current treatment modalities mainly relieve pain and inhibit cartilage degradation, but do not promote regeneration. In this study, we show that G protein-coupled receptor class C group 5 member B (GPRC5B), an orphan G-protein-couple receptor, only inhibits also increases regeneration thereby protective against OA. We observed Gprc5b deficient chondrocytes had upregulation catabolic gene expression, along with...
The chondrogenic differentiation of mesenchymal stem cells (MSCs) to enhance cartilage repair and regeneration is a promising strategy alleviate osteoarthritis (OA) progression. potency JD-312 in inducing MSCs was assessed verified. efficacy JD-312-treated evaluated using Sprague–Dawley rat DMM model. Additionally, the capacity successfully recruit bone marrow-derived (BMSCs) for treatment OA vitro confirmed via intra-articular injection. status articular analyzed vivo through histological...
To have greater impact on application it is desirable to integrate machines and their associated power electronic converters into complicated systems that share component count minimise cost. However, while compactness of achieved, reliability the conversion components can be compromised by arduous nature system operating environments. This paper investigates using higher phase numbers for electromagnetic specifically targeting improved specific volumetric density increased lifetime. Key...
In this experiment, we established an animal model of gestational diabetes mellitus rats using streptozotocin. Using the rat GDM, pregnant in 1-19d were divided into three groups: (1) Zuogui Wan group (group I, n = 12), (2) as control II, 11), and (3) normal pregnancy III, 11). Compared with group, can change indexes fasting blood glucose, body weight, total cholesterol, insulin, metabolism cage index significantly group. We conclude that has therapeutic effect on mellitus.
In this experiment, we used streptozotocin (STZ) to establish a model of gestational diabetes mellitus (GDM) rats, where Zuogui Wan was given GDM rats. After pregnancy, offspring rats were divided into 4 groups: control group, high fat and sugar as the group. Rats in group fed with diet. basic The means 2hPG higher than 7.8 mmol·L −1 lower 11.1 on week 15, IGT models successful. Body weight, abdominal ratio weight body fasting plasma glucose, 2hPG, insulin, leptin, total cholesterol, low...
An intelligent fault diagnosis system based on neural network and expert integration is studied. The uses networks to acquire codes the corresponding type of fault, which are stored knowledge base. In diagnosis, that can be found from base through forward reasoning, gives a reasonable solution. Meanwhile, this also overcomes some shortcomings doesn't have functional has difficult knowledge. Used in high-voltage circuit breaker simulation indicates method effective feasible.
Introduction The adverse effects of high glucose on embryos can be traced to the preimplantation stage. This study aimed observe effect early-stage embryos. Methods and results Seven-week-old ICR female mice were superovulated mated, zygotes collected. randomly cultured in 5 different concentrations (control, 20mM, 40mM, 60mM 80mM glucose). cleavage rate, blastocyst rate total cell number used assess embryo quality. 40 mM was selected model levels this study. 40mM arrested early embryonic...
Context: The difference between the chemical polarities of two categories active constituents in Chinese angelica volatile oil (CAVO) and water extract (CAWE) greatly limit development clinical application preparation.Object: aim this study is to design prepare a “whole angelica” microemulsion (WCAM) that contains both CAVO CAWE at same time evaluate it vivo vitro.Materials methods: extracted from were used as aqueous phases, respectively, WCAM; its physicochemical property was observed,...
We investigated the effects of cortical devascularization on proliferation, differentiation, and migration neural stem cells (NSCs) in subventricular zone (SVZ) lateral ventricle adult rats. 60 male Wistar rats were randomly divided into control group devascularized group. At 15 30 days after cerebral cortices devascularized, euthanized immunohistochemical analysis was performed. The number PCNA-, Vimentin-, GFAP-positive bilateral SVZ wall superior ventricles 15- 30-day groups increased...
High concentration of glucose in culture medium affects the developmental process and quality pre-implantation embryo. This study examined effects Zuogui Wan (ZGW) supplementation on early embryo development cultured high-glucose medium.Embryos were with or without ZGW supplementation. Developmental rate competence was evaluated by cleavage rate, blastocyst total cell number, reactive oxygen species (ROS) level, glutathione (GSH) concentration, metabolome also measured to determine effect at...