A5103029819- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Morinda citrifolia extract uses
- Lung Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Skin Protection and Aging
- China's Ethnic Minorities and Relations
- Ginkgo biloba and Cashew Applications
- Neurofibromatosis and Schwannoma Cases
- Facial Nerve Paralysis Treatment and Research
- Sphingolipid Metabolism and Signaling
- Microfluidic and Capillary Electrophoresis Applications
- China's Socioeconomic Reforms and Governance
- Bioactive Compounds and Antitumor Agents
- Medicinal Plants and Bioactive Compounds
Beijing University of Chinese Medicine
2012-2024
Chifeng University
2024
Fourth Affiliated Hospital of China Medical University
2022
China Medical University
2022
Sun Yat-sen University
2017-2020
Sun Yat-sen University Cancer Center
2017-2020
First Affiliated Hospital of Xi'an Jiaotong University
2019
State Key Laboratory of Oncology in South China
2018
Health First
2016
Xinjiang Medical University
2014
Mitochondrial oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease (AD). Recently, antioxidant therapy has been considered effective strategy for treatment AD. Our previous work discovered that rhein relieved mitochondrial β-amyloid (Aβ) oligomer-induced primary neurons by improving sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha- (PGC-1α-) regulated biogenesis. While encouraging results have provided, mechanisms...
The NLR family pyrin domain containing 3 (NLRP3) inflammasome in microglia is intimately linked to the pathogenesis of Alzheimer's disease (AD). Although NLRP3 activity regulated by cellular metabolism, underlying mechanism remains elusive. Here, we found that under pathological conditions AD, activation accompanied increased glutamine metabolism. Suppression glutaminase, rate limiting enzyme attenuated both AD mice and cultured inflammatory microglia. Mechanistically, inhibiting glutaminase...
Sanqi, the roots and rhizomes of Panax notoginseng safflower, flowers Carthamus tinctorius, are widely used traditional Chinese medicines (TCMs) for treatment cardiovascular diseases. Positive evidences have fueled growing acceptance cardioprotective effects combination total saponins safflower flavonoids (CNS) against myocardial ischemia (MI). However, underlying mechanisms CNS still obscured. Metabolomics is a comprehensive tool investigating biological disease, monitoring therapeutic...
Neuronal mitochondrial oxidative stress induced by β-amyloid (Aβ) is an early event of Alzheimer’s disease (AD). Emerging evidence has shown that antioxidant therapy represents a promising therapeutic strategy for the treatment AD. In this study, we investigated activity rhein against Aβ 1-42 oligomer-induced in primary neurons and proposed potential pathway involved. The results suggested significantly reduced reactive oxygen species (ROS) level, reversed depletion membrane potential,...
High-resolution mass spectrometry has been a powerful tool for the research of chemical constituents in traditional Chinese medicine (TCM) formulas. However, chromatographic peaks were difficult to discriminate clearly data collection or analysis because complexity and greatly different content TCM formula, which increased difficulty identification. In this study, high-performance liquid chromatography coupled with linear ion trap-Orbitrap based strategy focused on comprehensive...
The characterization of unknown compounds is still a great challenge currently. A strategy for deduction potential new phthalides through the isomers based on ultra-performance liquid chromatography coupled with quadrupole time flight tandem mass spectrometry was proposed here to characterize Ligusticum chuanxiong Hort. (Chuanxiong). This consisted four steps: (1) high resolution MS data collected, and peaks were screened preliminarily by UNIFITM platform in-house database; (2) fragmentation...
An Introduction to the volume. Special Edition: Review of Black Political Economy. December, 2012. The Economy Race and Ethnicity in China.
Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the pathological results. However, RLN sampling is difficult and imminent clinic setting. We recently developed a novel minimally invasive technique termed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) tissues sufficient or cytological diagnosis.We enrolled 30 post-radiotherapy NPC...
Objective: To assess the efficacy and safety of artemether emulsion in patients with papulopustular rosacea. Methods: A total 130 (randomized 1:1) were externally administered either (1%) or metronidazole (3%) twice daily for 4 weeks an open-label 8-week follow-up. The primary endpoints included proportion who achieved clinical effective responses, as well erythema papule pustule score at week 4. Results: Numerically more response (87.1%) than (80.0%) (p > .05). Patients had comparable...
Invasive mediastinal lymph node staging is essential to resectable non-small cell lung cancer (NSCLC) patients. This retrospective study aimed compare the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) against cervical mediastinoscopy (CMS) in radiologically enlarged nodes.Retrospective data were collected from January 2009 March 2016. Suspected patients with nodes (short axis ≥10 mm), underwent EBUS-TBNA or CMS for invasive enrolled....
Abstract How to identify the traces with weak response and poor mass spectrometry data is still a barrier comprehensively characterize chemical constituents of traditional Chinese medicine formula. Thus, we took Kangfuxiaoyanshuan as carrier perform method toward these in spectra. Chemical profiling spectra each herb formula were firstly obtained by an ultra‐high‐performance liquid chromatography coupled linear ion trap‐Orbitrap spectrometry. Next, high identified suspicious classified...
Quality marker (Q-marker) serves as an important driver for the standardization of quality control in traditional Chinese medicine (TCM) formulas. However, it is still challenging to discover comprehensive and representative Q-markers. This study aimed identify Q-markers Hugan tablet (HGT), a famous TCM formula with ideal clinical effects liver diseases. Here, we proposed funnel-type stepwise filtering strategy that integrated secondary metabolites characterization, characteristic...
Large temporal plexiform neurofibroma (PNF) is an irritating problem that causes facial disfigurement. Surgical resection of PNF the only effective way to remove tumor as well improve patient's appearance. However, branch nerve (TBFN) in prone be destroyed during removal. Thus, TBFN palsy inevitable complication after surgery and might induce other malformation dysfunction. Therefore, aim this study reconstruct a nearly normal face contour while preserving function.Selective removal...
• A strategy for in situ metabolically synthesized active drug-based probes was proposed. The potential purgative targets of SA were successfully hooked and identified. work provided a new insight studying the direct unstable drugs.
Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition not yet elucidated. Thus, rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was both positive- negative-ion modes to rapidly separate identify main ingredients XHSS first time. Finally, optimised separation detection...
To explore the method of establishing a cell model traditional Chinese medicine (TCM) syndromes, HepG2 cells were induced by human serum liver-depression and spleen-deficiency syndrome(LDSDS) to establish LDSDS in this research. The concentration cells, content culture medium growth characteristics model-cell (cell curve, survival rate apparent morphology investigated MTT assay microscopy. Evaluation syndrome model: metabolomics was used analyze normal individuals patients with LDSDS, models...