A5056742068- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Supramolecular Self-Assembly in Materials
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Antimicrobial agents and applications
- Dendrimers and Hyperbranched Polymers
- Chromatography in Natural Products
- Traditional Chinese Medicine Analysis
- Analytical Chemistry and Chromatography
- Advanced Photocatalysis Techniques
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Polydiacetylene-based materials and applications
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Antimicrobial Peptides and Activities
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Multilingual Education and Policy
- Advanced Nanomaterials in Catalysis
- Pharmacological Effects of Natural Compounds
- Cancer-related Molecular Pathways
- X-ray Diffraction in Crystallography
Qiqihar Medical University
2014-2025
China Medical University
2011-2025
Nanjing Drum Tower Hospital
2025
Shenzhen University
2020-2024
Tiangong University
2024
Chongqing University of Posts and Telecommunications
2024
Zhejiang Cancer Hospital
2022-2024
Xiamen University of Technology
2020-2024
Chinese Academy of Sciences
2022-2024
Huainan Normal University
2023
One-for-all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due its excellent performance in cancer treatment. Benefitting from the superiority balancing diverse competing energy dissipation pathways, aggregation-induced emission luminogens (AIEgens) are proven be ideal templates for constructing one-for-all multimodal phototheranostic agents. However, this knowledge,...
BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the has E3 ubiquitin ligase activity, domains specifically recognize phospho-serine Here, we demonstrate that catalyzes CtIP ubiquitination in a manner depends on phosphorylation-mediated interaction between domains. The BRCA1-dependent of does not target for degradation. Instead, ubiquitinated associates with chromatin following DNA damage participates G2/M checkpoint...
A strategy to construct high-ordered protein nanowires by electrostatic assembly of cricoid proteins and "soft nanoparticles" was developed. Poly(amido amine) (PAMAM) dendrimers on high generation that have been shown be near-globular macromolecules with all the amino groups distributing throughout surface were ideal electropositive induce electronegative proteins. Atomic force microscopy transmission electron showed one nanoparticle" (generation 5 PAMAM, PD5) could electrostatically...
Abstract The ingenious construction of versatile cancer phototheranostics involving fluorescence imaging (FLI) and photodynamic photothermal therapies (PDT, PTT) concurrently has attracted great interest. By virtue their inherent twisted structures plentiful motion moieties, aggregation‐induced emission luminogens (AIEgens) have been proven to be perfect templates for the development multimodal phototheranostic systems as diverse energy consumption pathways can flexibly regulated through...
Polymer nanocapsules and 2D-polymer films were successfully constructed by using a novel laterally functionalized pillararene derivative.
Herein, a new reductive-responsive pillar[5]arene-based, single-molecule-layer polymer nanocapsule is constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer excellent inhibition tumor cell proliferation exhibits low side effect on normal cells. This work not only demonstrates...
Controllable construction of diversiform topological morphologies through supramolecular self-assembly on the basis single building block is vital importance, but still remains a big challenge. Herein, bola-type supra-amphiphile, namely DAdDMA@2β-CD, rationally designed and successfully prepared by typical host-guest binding β-cyclodextrin units with an aggregation-induced emission (AIE)-active scaffold DAdDMA. Self-assembling investigation reveals that several self-assembled DAdDMA@2β-CD...
Two novel 3′,4′,5′-trifluorobiphenyl-based aromatic polyimide monomers, 2,2′-bis[4′-(3′′,4′′,5′′-trifluorophenyl)phenyl]-4,4′-biphenyl diamine (BTFBPD) and 2,2′-bis[4′-(3′′,4′′,5′′-trifluorophenyl)phenyl]-4,4′,5,5′-biphenyltetracarboxylic dianhydride (BTFBPDA) were synthesized. fluorinated polyimides (PIs), PI(BTFBPD-DPBPDA) PI(BTFBPD-BTFBPDA) prepared via a two-step procedure using BTFBPD reacting with 2,2′-diphenyl-4,4′,5,5′-biphenyltetracarboxylic (DPBPDA) BTFBPDA, respectively. was...
A spherical iron oxide precursor was prepared using a solvothermal method, and then treated thermally at 400°C to obtain α-Fe2O3 nanoparticles. The structures morphology of the as-obtained products were characterized X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning (SEM). results showed that diameter nanoparticles approximately 500 nm. In addition, we formed into thick film as gas sensor performed sensing test. When working temperature set 250°C, nanoparticle...
Utilizing solar energy for photocatalytic CO2 reduction is an attractive research field because of its convenience, safety, and practicality. The selection appropriate photocatalyst the key to achieve efficient reduction. Herein, we report synthesis TiO2/CuPc heterojunctions by compositing CuPc with TiO2 microspheres via a hydroxyl-induced self-assembly process. experimental investigations demonstrated that optimal TiO2/0.5CuPc exhibited significantly enhanced photoreduction rate up 32.4...
Local anesthetics have been widely used in clinical analgesia due to their ability provide effective regional pain management. Accurate measurement of local body fluids is crucial for ensuring patient medication safety and optimizing therapeutic efficacy. Herein, we present a convenient, economical, sensitive, efficient TLC-SERS method multiplex determination six kinds (pro) human plasma, including procaine hydrochloride (Pro), tetracaine (Tet), dibucaine (Dib), mepivacaine (Mep), lidocaine...
BACKGROUND: Gastric neuroendocrine neoplasms (g-NENs) are a rare type of stomach tumor. However, limited data exist about the expression and clinical significance B7 family ligands/receptors in patients with g-NENs. Thus, we conducted present study to address this issue cohort 112 METHODS: Using immunohistochemistry, mapped quantified molecules programmed cell death ligand 1 2 (PD-L1 PD-L2), B7-H3, B7-H4, recombinant human galectin-9 (LGALS9) CD155 gastric neoplasm samples. Associations...
A light-stimuli-responsive supramolecular azobenzene-containing M<sub>2</sub>L<sub>4</sub> cage has been designed and synthesized. This can be reversibly disassembled/reassembled mediated by the azo-ligand under visible UV light irradiation.