A5074920933- Oral microbiology and periodontitis research
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- interferon and immune responses
- Bacterial biofilms and quorum sensing
- NF-κB Signaling Pathways
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Cell death mechanisms and regulation
- Organoselenium and organotellurium chemistry
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Genomics and Phylogenetic Studies
- Streptococcal Infections and Treatments
- Transgenic Plants and Applications
- Click Chemistry and Applications
- Amyotrophic Lateral Sclerosis Research
- Salivary Gland Disorders and Functions
- Viral gastroenteritis research and epidemiology
- Estrogen and related hormone effects
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Infective Endocarditis Diagnosis and Management
- Vanadium and Halogenation Chemistry
- RNA and protein synthesis mechanisms
Jianghan University
2025
Nantong University
2025
Nankai University
2025
Dalian Institute of Chemical Physics
2016-2025
Chinese Academy of Sciences
2016-2025
University of Manitoba
2024
Chongqing Medical University
2022-2024
St Joseph's Health Care
2024
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
A strategy to construct high-ordered protein nanowires by electrostatic assembly of cricoid proteins and "soft nanoparticles" was developed. Poly(amido amine) (PAMAM) dendrimers on high generation that have been shown be near-globular macromolecules with all the amino groups distributing throughout surface were ideal electropositive induce electronegative proteins. Atomic force microscopy transmission electron showed one nanoparticle" (generation 5 PAMAM, PD5) could electrostatically...
Periodontitis is the most widespread oral disease and closely related to microbiota. The microbiota adversely affected by some pharmacologic treatments. Systemic antibiotics are widely used for infectious diseases but can lead gut dysbiosis, causing negative effects on human body. Whether systemic antibiotic-induced dysbiosis affect or even periodontitis has not yet been addressed. In this research, mice were exposed drinking water containing a cocktail of four explore how pathogenicity bone...
Despite being fundamentally important and having direct therapeutic implications, the functional genomics of clinical isolates multidrug-resistant (MDR) pathogens is often impeded by lack genome-editing tools. Here, we report establishment a highly efficient, in situ technique applicable environmental prototypic MDR pathogen P. aeruginosa harnessing endogenous type I-F CRISPR-Cas systems. Using this approach, generate various reverse mutations an epidemic genotype, PA154197, identify...
Among cariogenic microbes, Streptococcus mutans is considered a major etiological pathogen of dental caries. Lactobacilli strains have been promoted as possible probiotic agents against S. mutans, although the inhibitory effect on caries has not yet properly addressed. The objective this study was to screen Lactobacillus found in traditional Sichuan pickles and evaluate their antagonistic properties vitro vivo. In current study, we analyzed 54 isolated from that strain L. plantarum K41...
Streptococcus mutans is the primary etiological agent of human dental caries. Its major virulence factors, glucosyltransferases (Gtfs), utilize sucrose to synthesize extracellular polysaccharides (EPS), leading formation plaque biofilm. The current study was designed develop a novel self-targeting gene editing technology that targeted gtfs inhibit biofilms formation. CRISPR-Cas system (ie, clustered regularly interspaced short palindromic repeat, with CRISPR-associated proteins) provides...
The factors determining the pH dependence of formation and decay O photointermediate bacteriorhodopsin (bR) photocycle were investigated in wild-type (WT) pigment mutants Glu-194 Glu-204, key residues proton release group (PRG) bR. We have found that WT rate constant → bR transition decreases 30-fold upon decreasing from 6 to 3 with a pKa about 4.3. D2O slows rise intermediate at 3.5 by factor 5.5. suggest (which reflects deprotonation primary acceptor Asp-85) low is controlled PRG. To test...
The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and mechanisms 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from dental plaque healthy human population. Broth microdilution minimum inhibitory concentrations (MICs) revealed that all isolates were nonsusceptible to oxacillin penicillin G. Most them also resistant trimethoprim (65.7%)...
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as a new mode of intercellular crosstalk and are responsible for many the therapeutic effects MSCs. To promote application MSC-EVs, recent studies focused on manipulation MSCs to improve production EVs EV-mediated activities. The current paper details an optimization method using non-invasive low-intensity pulsed ultrasound (LIPUS) stimulation improving oral MSC-EV effectiveness. Stem apical papilla (SCAP),...
We developed the fluorogenic SNAP probe BGAN-8C to monitor protein degradation. It exhibited a 6-fold fluorescence enhancement upon binding with SNAP-tag. After is degraded, of...
Characteristics of groundwater level changes may be correlated with subsequent earthquake events. However, the relationship and its determining factors remain unclear. This study examines eight wells situated near Longmenshan-Anninghe fault zone, which exhibit significant disparities in level. We quantified these by Molchan diagram investigated that affect it using correlation assessments. The results indicate levels are more responsive to static stresses tidal forces also have a high...
The application of robot-assisted surgical technology in treating brainstem hemorrhage has garnered increasing attention. Treatments such as stereotactic hematoma aspiration and neuroendoscopic surgery are becoming more prevalent China. aim this study is to provide a detailed comparative analysis the clinical effects puncture versus traditional conservative treatment, offering scientific basis for optimizing treatment plans improving patient outcomes. A retrospective observational was...