A5101591865- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Atrial Fibrillation Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Smart Grid Energy Management
- Catalytic Processes in Materials Science
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotic Resistance in Bacteria
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Analytical Chemistry and Chromatography
- Hepatocellular Carcinoma Treatment and Prognosis
- Electric Vehicles and Infrastructure
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacovigilance and Adverse Drug Reactions
- High Altitude and Hypoxia
- Mass Spectrometry Techniques and Applications
- Polyamine Metabolism and Applications
- Electric Power System Optimization
- Plasma Applications and Diagnostics
- Pharmacogenetics and Drug Metabolism
- Polyomavirus and related diseases
- Advanced Chemical Sensor Technologies
Shanghai Electric (China)
2025
Beijing Friendship Hospital
2021-2023
Capital Medical University
2015-2023
Capital University
2021-2022
Central Hospital of Wuhan
2019-2022
Huazhong University of Science and Technology
2019-2022
Aix-Marseille Université
2021
Milken Institute
2021
University of North Carolina at Chapel Hill
2021
Beijing University of Chinese Medicine
2013-2016
Tigecycline has broad-spectrum anti-bacterial activity and often used for critically ill patients with complicated infections. Only a few clinical studies have reported the coagulation disorder induced by tigecycline. The aim of this study was to investigate association between tigecycline dysfunction using US Food Drug Administration Adverse Event Reporting System (FAERS) database.Data from January 2005 December 2020 in FAERS were retrieved. We investigated characteristics events conducted...
The role of anticoagulants in the treatment cirrhotic PVT remains controversial. This study aimed to analyze safety and efficacy anticoagulant therapy patients with portal vein thrombosis (PVT) its impact on prognosis.A retrospective cohort was conducted for liver cirrhosis our hospital. primary outcome recanalization rate. Other outcomes included bleeding rate, function, mortality. Cox Logistic regression were used explore risk factors outcomes.This 77 that 27 group 50 non-anticoagulant...
Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford certain anti-febrile action. However, seldom does research concern pharmacological mechanisms SHLI. In current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to...
Fever is one of the most common clinical symptoms many diseases. Qingkailing (QKL) injection widely used in China as a emergency medicine due to its good antipyretic effects. It herbal formula which composed by eight kinds traditional Chinese medicines (TCM). As kind typical multiple constituents and actions TCM, it very difficult elaborate mechanism conventional pharmacological method. Metabonomics technique provides beneficial tool for this challenge. In study, an ultra performance liquid...
With a background of carbon peak and neutrality, the economic environmental requirements are increasing for microgrids. In view problem energy wastage conflicts interest among multiple microgrid integrated systems, it is important to study operation optimization clusters while considering sharing trading both emissions green certificates. this study, Stackelberg game mechanism applied, in which operator leader its subscribers followers, forming master–slave interaction model. Following this,...
Under ambient conditions, H2O2 has been synthesized with 32.51% yield and 56.25% selectivity via the gas-phase reaction of H2/O2 non-equilibrium plasma.
Xenobiotic metabolome identification of Chinese herbal formula in biological systems is a very challenging task. Qingkailing injection typical injection, which wildly used clinically China. However, the holistic metabolic fate ingredient from remains unclear. In this work, metabolomic strategy for comprehensively elucidating derived prototype components and metabolites rat urine conducted by hybrid linear ion trap high‐resolution mass spectrometry was developed. High‐performance liquid...
Abstract Background Hepatic failure induced by immune checkpoint inhibitors (ICIs) has been reported in only a few case series and reports. Objective We aimed to explore the association between ICIs hepatic characterize clinical features of ICI‐associated pharmacovigilance database. Methods Data from first quarter (Q1) 2015 fourth (Q4) 2021 US Food Drug Administration Adverse Event Reporting System (FAERS) database were retrieved for disproportionality Bayesian analysis. odds ratios (ROR)...
ABSTRACT Qingkailing (QKL) injection, a modified modern Chinese medicine preparation, is widely used in the clinic for its significant antipyretic and anti‐inflammatory effects, but serious adverse drug reactions have attracted more attention. Series of caffeoylquinic acids QKL are suspected to be allergens responsible these reactions. Therefore, pharmacokinetic studies needed. In this paper, simple, rapid sensitive ultra‐performance liquid chromatography–tandem mass spectrometry method was...
Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic to treat acute respiratory tract infection, pneumonia, influenza, and so forth. Despite the widespread clinical application, prototype components metabolites of SHLI have not fully elucidated, especially human body. To discover screen constituents or medicine biofluids tends be more difficult due complexity chemical compositions, metabolic reactions matrix effects. In this work,...
Many antibiotics are well known for being associated with adverse events (AEs) of central nervous system, ceftazidime/avibactam (CAZ/AVI) is a novel β-lactam/β-lactamase inhibitor combinations. In this commentary, we analyzed reports system disorders CAZ/AVI, meropenem, imipenem, ceftazidime, ceftriaxone, and cefepime in the Food Drug Administration (FDA) Adverse Event Reporting System database from January 2015 to March 2022.The reporting odds ratios (RORs) method was used detect safety...
Objective: In the last decade, dental implants have emerged as a crucial modality and serve an individual form of therapy for failure.However, disparities in host responses led to periimplantitis implant failure.The pathological mechanisms driving peri-implantitis remain largely unknown.In this study, we evaluated role oxidative stress advanced glycation end products (AGEs) progression failure, compared with chronic periodontal disease.Subjects Methods: Three patient groups...
Objective . Berberine has been used to treat nonalcoholic steatohepatitis (NASH), which addressed in many studies. In this study, we investigated the molecular pharmacology mechanisms of berberine using metabolomic techniques. Methods Sprague-Dawley rats were randomly divided into three groups (10 each group): (i) normal control group; (ii) high-fat diet- (HFD-) induced NASH model and (iii) HFD berberine-treated group (i.d. 200 mg/kg). The handling procedure lasted eight weeks. Then,...
Purpose By comparing and contrasting the two scenarios of power producers investing in renewable energy electricity sellers energy, we explore conditions under which profit growth carbon emission reduction can be realized, provide a theoretical basis for decision-making on investment by electric companies as well government policy formulation. Design/methodology/approach This paper constructs game model grid supply chain consisting leader generator follower seller context C&T mechanism,...
Qingkailing injection (QKLI), a modern traditional Chinese medicine preparation, has been widely used in clinics due to its fast and significant efficacy treatment of high fever. The free amino acids (AAs) were considered be the most abundant active ingredients indisputably. So developing an accurate simple determination method measure contents total AAs QKLI is very crucial. In current study, using one single standard AA for simultaneous quantification multiple (One M) was developed....
During the process of metabolomics profiling by using ultra high performance liquid chromatography coupled with time-of flight mass spectrometry, blood sample pretreatment is a crucial step for biomarker discovery. Herein, in order to prevent potential loss metabolites and ion suppression phenomena caused proteins phospholipids contained fluids, delipidation-based solid-phase extraction technique plasma broad-coverage metabolomic was performed. This can be summarized as single extraction,...