A5100784778- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Genomics, phytochemicals, and oxidative stress
- Ruminant Nutrition and Digestive Physiology
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Air Quality and Health Impacts
- Artificial Intelligence in Healthcare
- Protein Hydrolysis and Bioactive Peptides
- Biochemical and Molecular Research
- Soil Moisture and Remote Sensing
- Bioactive Compounds and Antitumor Agents
- Molecular Junctions and Nanostructures
- Circular RNAs in diseases
- Epilepsy research and treatment
- Extracellular vesicles in disease
- Remote Sensing in Agriculture
- Environmental Impact and Sustainability
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Pharmacy and Medical Practices
- Antibiotic Resistance in Bacteria
- Municipal Solid Waste Management
Shanghai Jiao Tong University
2023-2024
Hainan University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2022
Xiyuan Hospital
2010-2022
Affiliated Hospital of Southwest Medical University
2022
Shanghai Institute of Nutrition and Health
2022
Shanghai Institutes for Biological Sciences
2022
Guilin University of Technology
2021
Jiangsu University of Science and Technology
2021
Northeast Normal University
2020
Abstract Background The rumen microbiota provides essential services to its host and, through role in ruminant production, contributes human nutrition and food security. A thorough knowledge of the genetic potential microbes will provide opportunities for improving sustainability production systems. availability gene reference catalogs from gut microbiomes has advanced understanding health disease humans other mammals. In this work, we established a catalog prokaryote genes bovine rumen....
In this work, a sensitive electrochemiluminescent assay of mucin 1 (MUC1) was developed with the advantages target recycling amplification strategy and effective MoS2 nanoflower (MoS2 NF)-based signal probe. Briefly, MUC1 triggered enzyme-free double-output process executed to acquire masses single-stranded DNA as mimic target, which further participated in catalytic hairpin assembly for amplification. Meanwhile, NFs were prepared an co-reaction accelerator, not only possessed excellent...
As the dominant waste disposal process, incineration is regarded as main incentive for "not-in-my-backyard" syndrome, and faces an inescapable pressures of ultra-low emissions (ULE). Establishing precise response relationships between emission factors (EFs) full-process influencing can provide guidance synergistic mitigation flue gas pollutants (FGPs). In this work, multi-dimensional EFs FGPs were identified by initially integrating concentration monitoring data existing 1,226 processing...
A ferrocene-switched electrochemiluminescence “off–on” sensor is proposed on the basis of target transduction and a DNA walking machine for sensitive detection cardiac troponin I.
Numerous clinical therapeutic agents have been identified as DNA damaging. The present study revealed that isoproterenol (Iso) resulted in damage vascular smooth muscle cells (VSMCs) and increased the levels of intracellular oxygen free radicals. Administration chlorogenic acid (CGA) inhibited this effect. Pretreatment with CGA abrogated increase protein expression γ‑H2A histone family member X, phosphorylated ataxia telangiectasia mutated, Rad3‑related protein, breast cancer 1 C‑terminal...
Non-coding RNAs (ncRNA) are a kind of RNA that does not encode protein, which play an important role in Alzheimer's disease (AD). However, there is lack bibliometric analysis and visualization the research related to AD ncRNAs.Literature ncRNAs last decade were searched through Web Science Core Collection (WOSCC). The relevant information from all articles was collected. website, CiteSpace, VOSviewer used for countries/regions, institutions, authors, keywords.In total, 1,613 kinds literature...
Abstract Personal greenhouse gas (P GHG ) emissions were crucial for achieving carbon peak and neutrality targets. The accounting methodology driving forces identification of P helpful the quantification reduction emissions. In this study, was developed from resource obtaining to waste disposal, variations Shanghainese 2010 2020 evaluated, with analysis based on Logarithmic Mean Divisia Index (LMDI) model. It showed that decreased 3796.05 (2010) 3046.87 kg dioxides (CO 2 (2014) then...
Many antibiotics are well known for being associated with adverse events (AEs) of central nervous system, ceftazidime/avibactam (CAZ/AVI) is a novel β-lactam/β-lactamase inhibitor combinations. In this commentary, we analyzed reports system disorders CAZ/AVI, meropenem, imipenem, ceftazidime, ceftriaxone, and cefepime in the Food Drug Administration (FDA) Adverse Event Reporting System database from January 2015 to March 2022.The reporting odds ratios (RORs) method was used detect safety...
The eastern part of Hainan, China, has a flat terrain and suitable climate with abundant sunshine rain. This unique environment makes the tropical microbial resources natural fermented food rich. Therefore, we combined Shotgun metagenomic sequencing, 16S rRNA sequencing pure culture technology to analyze diversity, microbiota composition, species differences correlation 30 traditional samples collected from Wenchang, Qionghai, Wanning Lingshui in Hainan province, isolated, identified...
(20S)-20-O-beta-D-Glucopyranosyl-protopanaxadiol (1) has been isolated as a metabolite of ginseng saponins by Paecilomyces bainier. The compound crystallizes in the monoclinic space group P2(1) with unit cell parameters a=11.523(6) A, b=12.383(6) c=14.233(7) beta=96.862(9) degrees , and Z=2. crystal structure solved direct methods refined to R=0.0536 for 4569 observed reflections. In structure, water methanol molecules link into infinite supramolecular layers through hydrogen bonds....
Abstract Background The rumen microbiota provides essential services to its host and, through role in ruminant production, contributes human nutrition and food security. A thorough knowledge of the genetic potential microbes will provide opportunities for improving sustainability production systems. availability gene reference catalogs from gut microbiomes has advanced understanding health disease humans other mammals. In this work, we established a catalog prokaryote genes bovine rumen....
Hypertension is a leading risk factor for cardiovascular diseases. Traditional blood pressure monitoring methods are cumbersome and inadequate continuous tracking, prompting the development of PPG-based cuffless wearables. This study leverages deep learning models, including ResNet Transformer, to analyze wrist PPG data collected with smartwatch efficient hypertension screening, eliminating need handcrafted features. Using Home Blood Pressure Monitoring (HBPM) longitudinal dataset 448...
张 楠 a 王思远 李 佳 * ,b ( 辽宁师范大学化学化工学院 大连 116029) b 中国科学院上海药物研究所 国家新药筛选中心 药物研究国家重点实验室 上海 201203) c 大连理工大学精细化工国家重点实验室 116012) 摘要 以邻苯二胺和一氯乙酸为初始原料, 经多步反应, 合成了一系列新型含苯并咪唑环和芳磺酰基的 3,6-二取代三 唑并噻二唑衍生物 7a～7y.利用 1 H NMR、IR 和元素分析对新的中间体化合物 3、4、6 及目标产物 7 进行了结构表征.对所合成的目标化合物进行了细胞分裂周期 25B 磷酸酶(Cdc25B)和蛋白酪氨酸磷酸酶 1B (PTP1B)抑制活性筛选, 实验 结果显示, 部分目标化合物对 Cdc25B 和 PTP1B 显示出良好的抑制活性, 其中目标化合物 7d 对 的抑制活性最 高[IC 50 ＝(7.72±0.73)g/mL], 7u 的抑制活性最高[IC ＝(3.31±0.57)g/mL].值得注意的是, 化合物 7b、 7d、 7l、7t 均具有抑制活性.这些活性的目标化合物是潜在的 抑制剂, 在癌症...
Objective To evaluate the clinical performance of chemiluminescent immunoassay (CLIA) on anti-nuclear antibody(ANA) specific autoantibodies testing. Methods A multi-center study A total 811 Sera samples were collected from 6 collaborating hospitals during period April to July 2016, and tested with CLIA line (LIA) in parallel for ribonucleoprotein(RNP), smith antigen(Sm), SSA/Ro60, SSB/La, centromere protein B(CENPB), double-stranded DNA(dsDNA), nucleosome(Nuc), ribosome P...